Cabral_1991_Tumori_77_185

Reference

Title : A rapid in vivo bioassay for the carcinogenicity of pesticides - Cabral_1991_Tumori_77_185
Author(s) : Cabral R , Hoshiya T , Hakoi K , Hasegawa R , Fukushima S , Ito N
Ref : Tumori , 77 :185 , 1991
Abstract :

Eight pesticides were tested in a bioassay based on the induction of preneoplastic lesions in the liver. Rats were given diethylnitrosamine intraperitoneally at 200 mg/kg bw and two weeks later were treated with pesticides for six weeks and then killed; all rats had a partial hepatectomy at week 3. Hepatocarcinogenic potential was assessed by comparing the number and area of glutathione s-transferase (placental form) -positive foci in the liver with those of controls given diethylnitrosamine alone. Positive results were seen with Chinomethionat, Phosmet and Propiconazole; the results obtained with Captan and Prochloraz were borderline; Benomyl, Daminozide and Folpet gave negative results. Our findings provide enough experimental evidence to indicate that great care should be exercised in the use of these compounds.

PubMedSearch : Cabral_1991_Tumori_77_185
PubMedID: 1862543

Related information

Inhibitor Phosmet    Benomyl
Chemical Phosmet    Benomyl    Quinomethionate

Citations formats

Cabral R, Hoshiya T, Hakoi K, Hasegawa R, Fukushima S, Ito N (1991)
A rapid in vivo bioassay for the carcinogenicity of pesticides
Tumori 77 :185

Cabral R, Hoshiya T, Hakoi K, Hasegawa R, Fukushima S, Ito N (1991)
Tumori 77 :185