Benomyl

Benomyl is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit.Benomyl binds to microtubules. No major toxic effects in mammals. It is not true cholinesterase inhibitor (LD50 of greater than 10,000 mg/kg/day for rats) Some cases of anophthalmia birth defects reported

General

Type : Carbamate, Fungicide, Imidazole, Benzimidazole

Chemical_Nomenclature : methyl N-[1-(butylcarbamoyl)benzimidazol-2-yl]carbamate

Canonical SMILES : CCCCNC(=O)N1C2=CC=CC=C2N=C1NC(=O)OC

InChI : InChI=1S\/C14H18N4O3\/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2\/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)

InChIKey : RIOXQFHNBCKOKP-UHFFFAOYSA-N

Other name(s) : [1-[Butylamino)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester, 1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid methyl ester, Arilate, Uzgen, Arbortrine, Fungochrom, Benomyl-Imex, Benlate, Tersan 1991, Benlate(R), Agrocit, Benosan, Du Pont 1991, Fundazol, Benex, BBC


MW : 290.32

Formula : C14H18N4O3

CAS_number : 17804-35-2

PubChem : 28780

UniChem : RIOXQFHNBCKOKP-UHFFFAOYSA-N

Wikipedia : Benomyl

Target

Families : Benomyl ligand of proteins in family
ACHE

References (10)

Title : Oxidative liver DNA damage in rats treated with pesticide mixtures - Lodovici_1997_Toxicology_117_55
Author(s) : Lodovici M , Casalini C , Briani C , Dolara P
Ref : Toxicology , 117 :55 , 1997
PubMedID: 9020199

Title : Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes - Urani_1995_Toxicol.Lett_76_135
Author(s) : Urani C , Chiesara E , Galvani P , Marabini L , Santagostino A , Camatini M
Ref : Toxicol Lett , 76 :135 , 1995
PubMedID: 7725345

Title : Genotoxicity assay of five pesticides and their mixtures in Saccharomyces cerevisiae D7 - Bianchi_1994_Mutat.Res_321_203
Author(s) : Bianchi L , Zannoli A , Pizzala R , Stivala LA , Chiesara E
Ref : Mutat Res , 321 :203 , 1994
PubMedID: 7515158

Title : Mixtures of benomyl, pirimiphos-methyl, dimethoate, diazinon and azinphos-methyl affect protein synthesis in HL-60 cells differently - Marinovich_1994_Toxicology_94_173
Author(s) : Marinovich M , Guizzetti M , Galli CL
Ref : Toxicology , 94 :173 , 1994
PubMedID: 7801320

Title : Increase of micronucleus frequency in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl separately and in mixture - Piatti_1994_Mutat.Res_324_59
Author(s) : Piatti E , Marabini L , Chiesara E
Ref : Mutat Res , 324 :59 , 1994
PubMedID: 7515471

Title : Effect of a mixture of 15 commonly used pesticides on DNA levels of 8- hydroxy-2-deoxyguanosine and xenobiotic metabolizing enzymes in rat liver - Lodovici_1994_J.Environ.Pathol.Toxicol.Oncol_13_163
Author(s) : Lodovici M , Aiolli S , Monserrat C , Dolara P , Medica A , Di Simplicio P
Ref : J Environ Pathol Toxicol Oncol , 13 :163 , 1994
PubMedID: 7722883

Title : Survey of imported green coffee beans for pesticide residues - Jacobs_1993_Food.Addit.Contam_10_575
Author(s) : Jacobs RM , Yess NJ
Ref : Food Additives & Contaminants , 10 :575 , 1993
PubMedID: 8224325

Title : Safety\/risk assessment of pesticides: principles, procedures and examples - Lu_1992_Toxicol.Lett_64_783
Author(s) : Lu FC , Dourson ML
Ref : Toxicol Lett , 64-65 :783 , 1992
PubMedID: 1471237

Title : A rapid in vivo bioassay for the carcinogenicity of pesticides - Cabral_1991_Tumori_77_185
Author(s) : Cabral R , Hoshiya T , Hakoi K , Hasegawa R , Fukushima S , Ito N
Ref : Tumori , 77 :185 , 1991
PubMedID: 1862543

Title : [Radiometric determination of 11 carbamate pesticides in the nanogram and subnanongram ranges by means of cholinesterase inhibition] - Schmid_1977_Nahrung_21_311
Author(s) : Schmid ER , Damboritz W , Markl P
Ref : Nahrung , 21 :311 , 1977
PubMedID: 406567