Camuzcuoglu_2009_J.Womens.Health.(Larchmt)_18_1435

Reference

Title : Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus - Camuzcuoglu_2009_J.Womens.Health.(Larchmt)_18_1435
Author(s) : Camuzcuoglu H , Toy H , Cakir H , Celik H , Erel O
Ref : J Womens Health (Larchmt) , 18 :1435 , 2009
Abstract :

OBJECTIVE: The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hydroperoxide (LOOH) levels in patients with gestational diabetes mellitus (GDM).
METHODS: Paraoxonase and arylesterase activities, and LOOH levels were assessed for GDM cases (n = 55) and controls (n = 59). Serum basal and salt-stimulated paraoxonase and arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay.
RESULTS: Basal and salt-stimulated paraoxonase and arylesterase activities were significantly lower (p = 0.002, p = 0.004; and p = 0.013, respectively) in patients with GDM compared to controls, while LOOH levels were significantly higher (p < 0.001). Among gestational diabetes patients, serum paraoxonase and arylesterase activities were inversely correlated with LOOH levels (r = - 0.390, p = 0.003; and r = - 0.287, p = 0.034, respectively).
CONCLUSIONS: Findings of the present study have shown that serum paraoxonase and arylesterase activities are significantly reduced in women with GDM. Decreased serum paraoxonase and arylesterase activities might play a role in the potential early pathogenesis for atherosclerotic heart disease in GDM beyond their antioxidant properties.

PubMedSearch : Camuzcuoglu_2009_J.Womens.Health.(Larchmt)_18_1435
PubMedID: 19698032

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Citations formats

Camuzcuoglu H, Toy H, Cakir H, Celik H, Erel O (2009)
Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus
J Womens Health (Larchmt) 18 :1435

Camuzcuoglu H, Toy H, Cakir H, Celik H, Erel O (2009)
J Womens Health (Larchmt) 18 :1435