Cao_1998_Zhonghua.Wai.Ke.Za.Zhi_36_424

OBJECTIVE: To study the effect of detrusor instability secondary to benign prostatic hypertrophy (BPH) on the density of cholinesterase-containing nerve in detrusor samples. METHOD: Our present study included 3 groups confirmed by urodynamic evaluation. They were control group (8 cases), obstructive detrusor stability group (7), and obstructive instability group (12). The specimens were obtained from the dome of bladder. The AchE-containing nerves were demonstrated by the method of Karnovsky-Roots staining and AchE silver staining. The density of AchE containing detrusor nerves in specimens was examined with sterologic techniques. RESULT: The density of AchE-containing nerves in the obstructive detrusor instability group and the stability group was significantly decreased as compared with the control group (P < 0.01). The density of AchE positive nerves were also significantly decreased in the obstructive instability group as compared with the obstructive stability group (P < 0.05). CONCLUSION: Detrusor instability secondary to BPH obstruction is related to the decrease of cholinergic innervation density in the detrusor muscles.