| Title : Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease - Castro_2001_Mini.Rev.Med.Chem_1_267 |
| Author(s) : Castro A , Martinez A |
| Ref : Mini Rev Med Chem , 1 :267 , 2001 |
|
Abstract :
Recently advances in understanding the molecular basis of Alzheimer's disease have led to the consideration of the relationship between cholinergic inhibitors and amyloid deposition as a new hypothesis for the future rational design of effective anti-Alzheimer drugs. In the present review, the non-cholinergic functions of acetylcholinesterase (AChE) and the therapeutic potential of peripheral and dual binding site AChE inhibitors in delaying the neurodegenerative process will be discussed. |
| PubMedSearch : Castro_2001_Mini.Rev.Med.Chem_1_267 |
| PubMedID: 12369973 |
Castro A, Martinez A (2001)
Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease
Mini Rev Med Chem
1 :267
Castro A, Martinez A (2001)
Mini Rev Med Chem
1 :267