| Title : Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase - Cateni_2007_Bioorg.Med.Chem.Lett_17_1971 |
| Author(s) : Cateni F , Bonivento P , Procida G , Zacchigna M , Scialino G , Banfi E |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :1971 , 2007 |
|
Abstract :
Monoglucosyl and monogalactosyl diglycerides (MGDGs) with medium-long length acyl chains, identified as active components in Euphorbiaceae, were synthesized. They were examined for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. MGDGs with two octanoyl groups at both 1- and 2-positions showed the most potent activity. The stereoselectivity of pancreatic lipase was investigated in vitro where the preference for the 1 position in MGDGs is strictly related to the length of the acyl chains. |
| PubMedSearch : Cateni_2007_Bioorg.Med.Chem.Lett_17_1971 |
| PubMedID: 17270436 |
Cateni F, Bonivento P, Procida G, Zacchigna M, Scialino G, Banfi E (2007)
Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase
Bioorganic & Medicinal Chemistry Lett
17 :1971
Cateni F, Bonivento P, Procida G, Zacchigna M, Scialino G, Banfi E (2007)
Bioorganic & Medicinal Chemistry Lett
17 :1971