Cavaliere_1998_J.Toxicol.Clin.Toxicol_36_295

Reference

Title : Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds - Cavaliere_1998_J.Toxicol.Clin.Toxicol_36_295
Author(s) : Cavaliere MJ , Puga FR , Calore EE , Calore NM , Pelegrino JR , da Rosa AR , Weg R
Ref : Journal of Toxicology Clinical Toxicology , 36 :295 , 1998
Abstract :

To determine the protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate acute intoxication in rats. DESIGN: Adult male Wistar rats were given oral organophosphate compounds dissolved in glycerol formal: dichlorvos, isofenphos, metamidophos, and diazinon. Half of the animals also received pralidoxime mesylate (20 mg/kg, intraperitoneal). Control animals received only the solvent. Twenty-four hours after treatment, the diaphragm muscle was collected for histological counts of necrotic muscle fibers in transverse sections. RESULTS: Metamidophos- and isofenphos-treated animals showed the highest percentage of necrotic muscle fibers: 1.66 +/- 1.112 and 1.34 +/- 0.320, respectively. Diazinon-treated animals had a lower percentage of necrotic fibers: 0.40 +/- 0.032 (p < 0.05) compared to the first 2 products, and dichlorvos-treated animals showed the smallest: 0.05 +/- 0.021 (p < 0.05) when compared to the other 3 products. Pralidoxime reduced necrotic fibers about 20 times in metamidophos-treated animals, 10 times in isofenphos-treated animals and 6 times in diazinon-treated animals. Pralidoxime administration did not increase plasma cholinesterase activity in any group, although symptoms were reduced. CONCLUSIONS: Oxime reduced diaphragmatic muscle necrosis in experimental organophosphate intoxication, despite little effect on plasma cholinesterase. Since respiratory insufficiency is an important cause of mortality and morbidity in organophosphate intoxications, early oxime administration may be particularly beneficial.

PubMedSearch : Cavaliere_1998_J.Toxicol.Clin.Toxicol_36_295
PubMedID: 9711194

Related information

Inhibitor Diazinon    Dichlorvos    Isofenphos    Methamidophos
Reactivator Diazinon    Dichlorvos    Isofenphos    Methamidophos    2-PAM

Citations formats

Cavaliere MJ, Puga FR, Calore EE, Calore NM, Pelegrino JR, da Rosa AR, Weg R (1998)
Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds
Journal of Toxicology Clinical Toxicology 36 :295

Cavaliere MJ, Puga FR, Calore EE, Calore NM, Pelegrino JR, da Rosa AR, Weg R (1998)
Journal of Toxicology Clinical Toxicology 36 :295