2-PAM
General
Chemical_Nomenclature : (NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine
Canonical SMILES : C[N+]1=CC=CC=C1C=NO
InChI : InChI=1S\/C7H8N2O\/c1-9-5-3-2-4-7(9)6-8-10\/h2-6H,1H3\/p+1
InChIKey : JBKPUQTUERUYQE-UHFFFAOYSA-O
Other name(s) : [(E)-(1-methylpyridin-2-ylidene)methyl]-oxoazanium || CHEMBL1420 || Pyridine-2-aldoxime || Pralidoxime || 2-hydroxyiminomethyl-N-methyl pyridinium || 2-Hydroxyiminomethyl-N-methyl-pyridinium || 1-methyl-2-formylpyridinium oxime || Pralidoximum || Protopam || UNII-P7MU9UTP52 || Duodote || 2PAM
MW : 137.159
Formula : C7H9N2O
CAS_number : 94-63-3
PubChem : 135398747, 5464070, 5353894, 5359226, 16219909, 12443620
UniChem : JBKPUQTUERUYQE-UHFFFAOYSA-O
IUPHAR : 7597
Wikipedia : Pralidoxime
References (80)
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| Abstract : |
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| Gene_locus related to this paper: human-ACHE |
| Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
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| Gene_locus related to this paper: human-ACHE |
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| Gene_locus related to this paper: human-BCHE |
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| Gene_locus related to this paper: torca-ACHE |
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| Title : Studies on the therapeutic effect of 2-pyridine aldoxime methiodide (2-PAM) in mammals following organophosphorus compound-poisoning (report III): distribution and antidotal effect of 2-PAM in rats - Uehara_1993_J.Toxicol.Sci_18_265 |
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| Title : Disposition and metabolism of acetylcholinesterase reactivators 2PAM-I, TMB4 and R665 in rats submitted to organophosphate poisoning - Garrigue_1991_Xenobiotica_21_583 |
| Author(s) : Garrigue H , Maurizis JC , Madelmont JC , Nicolas C , Meyniel JM , Louvel A , Demerseman P , Sentenac-Roumanou H , Veyre A |
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| PubMedSearch : Garrigue_1991_Xenobiotica_21_583 |
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| Title : A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning - Shih_1991_Toxicol.Lett_55_131 |
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| Abstract : |
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| Title : Use of pralidoxime-Pd(II) complex for the spectrophotometric determination of the cholinesterase reactivator (PAM-2Cl) in the urine - Karljikovic-Rajic_1990_Clin.Chim.Acta_193_119 |
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| Title : The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication - Harris_1989_Toxicol.Appl.Pharmacol_98_128 |
| Author(s) : Harris LW , Talbot BG , Lennox WJ , Anderson DR |
| Ref : Toxicology & Applied Pharmacology , 98 :128 , 1989 |
| Abstract : |
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| Ref : Journal of Applied Physiology , 66 :1390 , 1989 |
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| Title : Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice - Kaliste-Korhonen_1989_Gen.Pharmacol_20_805 |
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| Title : Kinetic investigations into the interactions of aprophen with cholinesterases and a carboxylesterase - Rush_1986_Biochem.Pharmacol_35_4167 |
| Author(s) : Rush RS , Doctor BP , Wolfe AD |
| Ref : Biochemical Pharmacology , 35 :4167 , 1986 |
| Abstract : |
| PubMedSearch : Rush_1986_Biochem.Pharmacol_35_4167 |
| PubMedID: 3098245 |
| Title : Studies on the toxicity, metabolism, and anticholinesterase properties of acephate and methamidophos - Hussain_1985_J.Env.Sci.Health_20_129 |
| Author(s) : Hussain MA , Mohamad RB , Oloffs PC |
| Ref : Journal of Environmental Science & Health Part B: Pesticides, Food Contaminants, & Agricultural Wastes , 20 :129 , 1985 |
| Abstract : |
| PubMedSearch : Hussain_1985_J.Env.Sci.Health_20_129 |
| PubMedID: 3989221 |
| Title : Reactivation of ethyl methylphosphonylated eel acetylcholinesterase in vitro by 2PAM, H16, and a series of nonquaternary alpha-ketothiohydroximates - |
| Author(s) : Kenley RA , Bedford CD , Howd RA , Jackson SE |
| Ref : Biochemical Pharmacology , 34 :3606 , 1985 |
| PubMedID: 4052103 |
| Title : Clinical observation and comparison of the effectiveness of several oxime cholinesterase reactivators - Xue_1985_Scand.J.Work.Environ.Health_4_46 |
| Author(s) : Xue SZ , Ding XJ , Ding Y |
| Ref : Scandinavian Journal of Work, Environment & Health , 4 :46 , 1985 |
| Abstract : |
| PubMedSearch : Xue_1985_Scand.J.Work.Environ.Health_4_46 |
| PubMedID: 3914075 |
| Title : Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites - Martin_1985_J.Neurol.Sci_71_1 |
| Author(s) : Martin LJ , Doebler JA , Anthony A |
| Ref : Journal of the Neurological Sciences , 71 :1 , 1985 |
| Abstract : |
| PubMedSearch : Martin_1985_J.Neurol.Sci_71_1 |
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| Title : Chemical reactivations of inactivated acetylcholinesterase after 2-PAM therapy in fenitrothion-poisoned rat and rabbit - Matsubara_1984_J.Pharmacobio.Dynamics_7_131 |
| Author(s) : Matsubara T , Horikoshi I |
| Ref : Journal of Pharmacobio Dynamics , 7 :131 , 1984 |
| Abstract : |
| PubMedSearch : Matsubara_1984_J.Pharmacobio.Dynamics_7_131 |
| PubMedID: 6726618 |
| Title : Nonquaternary cholinesterase reactivators. 2. Alpha-heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro - Kenley_1984_J.Med.Chem_27_1201 |
| Author(s) : Kenley RA , Bedford CD , Dailey OD, Jr. , Howd RA , Miller A |
| Ref : Journal of Medicinal Chemistry , 27 :1201 , 1984 |
| Abstract : |
| PubMedSearch : Kenley_1984_J.Med.Chem_27_1201 |
| PubMedID: 6471073 |
| Title : [Neurophysiologic study of the effect of 2PAM-Cl on the neuromuscular junction]. [Serbo-Croatian (Roman)] - |
| Author(s) : Stamenovic BA |
| Ref : Vojnosanitetski Pregled , 41 :326 , 1984 |
| PubMedID: 6516240 |
| Title : [Effects of organophosphorus compounds and PAM on cholinesterase activity in rat tissues]. [Japanese] - |
| Author(s) : Yamanaka S , Nishimura M |
| Ref : Nippon Eiseigaku Zasshi Japanese Journal of Hygiene , 39 :795 , 1984 |
| PubMedID: 6533340 |
| Title : PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning - Boskovic_1984_Fundam.Appl.Toxicol_4_S106 |
| Author(s) : Boskovic B , Kovacevic V , Jovanovic D |
| Ref : Fundamental & Applied Toxicology , 4 :S106 , 1984 |
| Abstract : |
| PubMedSearch : Boskovic_1984_Fundam.Appl.Toxicol_4_S106 |
| PubMedID: 6724203 |
| Title : Reactivation of VX-inhibited cholinesterase by 2-PAM and HS-6 in rats - Harris_1983_Drug.Chem.Toxicol_6_235 |
| Author(s) : Harris LW , Stitcher DL |
| Ref : Drug & Chemical Toxicology , 6 :235 , 1983 |
| Abstract : |
| PubMedSearch : Harris_1983_Drug.Chem.Toxicol_6_235 |
| PubMedID: 6628257 |
| Title : Brain neuronal RNA metabolism during acute soman toxication: effects of antidotal pretreatments - Doebler_1983_Neurochem.Res_8_997 |
| Author(s) : Doebler JA , Bocan TM , Moore RA , Shih TM , Anthony A |
| Ref : Neurochemical Research , 8 :997 , 1983 |
| Abstract : |
| PubMedSearch : Doebler_1983_Neurochem.Res_8_997 |
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| Title : Efficacy and toxicity of drug combinations in treatment of physostigmine toxicosis - Klemm_1983_Toxicology_27_41 |
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| Ref : Toxicology , 27 :41 , 1983 |
| Abstract : |
| PubMedSearch : Klemm_1983_Toxicology_27_41 |
| PubMedID: 6149635 |
| Title : Differential effects of di-isopropylfluorophosphate poisoning and its treatment on opioid antinociception in the mouse - Kitchen_1983_Life.Sci_1_669 |
| Author(s) : Kitchen I , Green PG |
| Ref : Life Sciences , 1 :669 , 1983 |
| Abstract : |
| PubMedSearch : Kitchen_1983_Life.Sci_1_669 |
| PubMedID: 6664242 |
| Title : Reactivation studies on organophosphate inhibited human cholinesterases by pralidoxime (P-2-AM) - Ganendran_1976_Southeast.Asian.J.Trop.Med.Public.Health_7_417 |
| Author(s) : Ganendran A , Balabaskaran S |
| Ref : Southeast Asian J Trop Med Public Health , 7 :417 , 1976 |
| Abstract : |
| PubMedSearch : Ganendran_1976_Southeast.Asian.J.Trop.Med.Public.Health_7_417 |
| PubMedID: 1030845 |
| Title : Pralidoxime as an insignificant reactivator in severe anticholinesterase (organophosphate insecticide) poisoning - Ganendran_1976_Southeast.Asian.J.Trop.Med.Public.Health_7_543 |
| Author(s) : Ganendran A , Balabaskaran S |
| Ref : Southeast Asian J Trop Med Public Health , 7 :543 , 1976 |
| Abstract : |
| PubMedSearch : Ganendran_1976_Southeast.Asian.J.Trop.Med.Public.Health_7_543 |
| PubMedID: 1030852 |
| Title : Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form - Shek_1976_J.Med.Chem_19_113 |
| Author(s) : Shek E , Higuchi T , Bodor N |
| Ref : Journal of Medicinal Chemistry , 19 :113 , 1976 |
| Abstract : |
| PubMedSearch : Shek_1976_J.Med.Chem_19_113 |
| PubMedID: 1246032 |
| Title : [Effect of some reactivators on cholinesterase activity in the chromodacryorrhea test in rats]. [Bulgarian] - Naneva_1976_Vet.Med.Nauki_13_81 |
| Author(s) : Naneva E |
| Ref : Veterinarno Meditsinski Nauki , 13 :81 , 1976 |
| Abstract : |
| PubMedSearch : Naneva_1976_Vet.Med.Nauki_13_81 |
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| Title : Toxogonin and pralidoxime: kinetic comparison after intravenous administration to man - |
| Author(s) : Sidell FR , Groff WA , Kaminskis A |
| Ref : Journal of Pharmaceutical Sciences , 61 :1765 , 1972 |
| PubMedID: 4569114 |
| Title : The reactivation by oximes and hydroxamic acids of cholinesterases inhibited by organophosphorus compounds - |
| Author(s) : Childs AF , Davies DR , Green AL , Rutland JP |
| Ref : British Journal of Pharmacology , 10 :462 , 1955 |
| PubMedID: 13276605 |
| Title : Reactivation of acetylcholinesterase inhibited by alkyl phosphates - |
| Author(s) : Wilson IB , Ginsburg S |
| Ref : Archives of Biochemistry & Biophysics , 54 :569 , 1955 |
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