2-PAM

General

Type : Oxime, Pyridine

Chemical_Nomenclature : (NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine

Canonical SMILES : C[N+]1=CC=CC=C1C=NO

InChI : InChI=1S\/C7H8N2O\/c1-9-5-3-2-4-7(9)6-8-10\/h2-6H,1H3\/p+1

InChIKey : JBKPUQTUERUYQE-UHFFFAOYSA-O

Other name(s) : [(E)-(1-methylpyridin-2-ylidene)methyl]-oxoazanium  ||  CHEMBL1420  ||  Pyridine-2-aldoxime  ||  Pralidoxime  ||  2-hydroxyiminomethyl-N-methyl pyridinium  ||  2-Hydroxyiminomethyl-N-methyl-pyridinium  ||  1-methyl-2-formylpyridinium oxime  ||  Pralidoximum  ||  Protopam  ||  UNII-P7MU9UTP52  ||  Duodote  ||  2PAM


MW : 137.159

Formula : C7H9N2O

CAS_number : 94-63-3

PubChem : 135398747,    5464070,    5353894,    5359226,    16219909,    12443620

UniChem : JBKPUQTUERUYQE-UHFFFAOYSA-O

IUPHAR : 7597

Wikipedia : Pralidoxime

Target

Structure : 5HFA, 4AXB, 2WG1, 2VQ6

Families : No family

References (80)

Title : Preferential Door for Ligand Binding and Unbinding Pathways in Inhibited Human Acetylcholinesterase - Kongkaew_2024_J.Phys.Chem.Lett__5696
Author(s) : Kongkaew N , Hengphasatporn K , Shigeta Y , Rungrotmongkol T , Harada R
Ref : J Phys Chem Lett , :5696 , 2024
Abstract :
PubMedSearch : Kongkaew_2024_J.Phys.Chem.Lett__5696
PubMedID: 38768263

Title : The reactivation kinetic analysis, molecular docking, and dynamics of oximes against three V-type nerve agents inhibited four human cholinesterases - Li_2024_Chem.Biol.Interact__111061
Author(s) : Li K , Liu Y , Li Q , Guo L , Xie J
Ref : Chemico-Biological Interactions , :111061 , 2024
Abstract :
PubMedSearch : Li_2024_Chem.Biol.Interact__111061
PubMedID: 38763347

Title : Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects - Blumenthal_2021_J.Biol.Chem__
Author(s) : Blumenthal DK , Cheng X , Fajer M , Ho KY , Rohrer J , Gerlits O , Taylor P , Juneja P , Kovalevsky A , Radic Z
Ref : Journal of Biological Chemistry , :101007 , 2021
Abstract :
PubMedSearch : Blumenthal_2021_J.Biol.Chem__
PubMedID: 34324828
Gene_locus related to this paper: human-ACHE

Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC
Ref : J Enzyme Inhib Med Chem , 34 :1018 , 2019
Abstract :
PubMedSearch : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
PubMedID: 31074292

Title : Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [(11)C]2-Pyridinealdoxime Methiodide ([(11)C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication - Neumann_2018_ACS.Chem.Neurosci_9_3007
Author(s) : Neumann KD , Blecha JE , Hayes TR , Huynh T , Chao CK , Guilloteau N , Zinn KR , VanBrocklin HF , Thompson CM , Gerdes JM
Ref : ACS Chem Neurosci , 9 :3007 , 2018
Abstract :
PubMedSearch : Neumann_2018_ACS.Chem.Neurosci_9_3007
PubMedID: 30071719

Title : Utility of 2-Pyridine Aldoxime Methyl Chloride (2-PAM) for Acute Organophosphate Poisoning: A Systematic Review and Meta-Analysis - Blumenberg_2018_J.Med.Toxicol_14_91
Author(s) : Blumenberg A , Benabbas R , deSouza IS , Conigliaro A , Paladino L , Warman E , Sinert R , Wiener SW
Ref : J Med Toxicol , 14 :91 , 2018
Abstract :
PubMedSearch : Blumenberg_2018_J.Med.Toxicol_14_91
PubMedID: 29230717

Title : Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface - Franklin_2016_Proteins_84_1246
Author(s) : Franklin MC , Rudolph MJ , Ginter C , Cassidy MS , Cheung J
Ref : Proteins , 84 :1246 , 2016
Abstract :
PubMedSearch : Franklin_2016_Proteins_84_1246
PubMedID: 27191504
Gene_locus related to this paper: human-ACHE

Title : Blood-fetus penetration of pralidoxime - Ojha_2016_Mil.Med.Sci.Lett_85_63
Author(s) : Ojha S , Nurulain SM , Dhanasekaran S , Shafiullah M , Adem A , Sharma C , Kuca K , Kalasz H
Ref : Military Medical Science Letters , 85 :63 , 2016
Abstract :
PubMedSearch : Ojha_2016_Mil.Med.Sci.Lett_85_63
PubMedID:

Title : A step toward the reactivation of aged cholinesterases - Crystal structure of ligands binding to aged human butyrylcholinesterase - Wandhammer_2013_Chem.Biol.Interact_203_19
Author(s) : Wandhammer M , De Koning MC , van Grol M , Loiodice M , Saurel L , Noort D , Goeldner M , Nachon F
Ref : Chemico-Biological Interactions , 203 :19 , 2013
Abstract :
PubMedSearch : Wandhammer_2013_Chem.Biol.Interact_203_19
PubMedID: 22922115
Gene_locus related to this paper: human-BCHE

Title : Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy - Kuca_2010_Bratisl.Lek.Listy_111_502
Author(s) : Kuca K , Hrabinova M , Soukup O , Tobin G , Karasova J , Pohanka M
Ref : Bratislavske Lekarske Listy , 111 :502 , 2010
Abstract :
PubMedSearch : Kuca_2010_Bratisl.Lek.Listy_111_502
PubMedID: 21180265

Title : Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial - Eddleston_2009_PLoS.Med_6_e1000104
Author(s) : Eddleston M , Eyer P , Worek F , Juszczak E , Alder N , Mohamed F , Senarathna L , Hittarage A , Azher S , Jeganathan K , Jayamanne S , von Meyer L , Dawson AH , Sheriff MH , Buckley NA
Ref : PLoS Med , 6 :e1000104 , 2009
Abstract :
PubMedSearch : Eddleston_2009_PLoS.Med_6_e1000104
PubMedID: 19564902

Title : Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime - Sanson_2009_J.Med.Chem_52_7593
Author(s) : Sanson B , Nachon F , Colletier JP , Froment MT , Toker L , Greenblatt HM , Sussman JL , Ashani Y , Masson P , Silman I , Weik M
Ref : Journal of Medicinal Chemistry , 52 :7593 , 2009
Abstract :
PubMedSearch : Sanson_2009_J.Med.Chem_52_7593
PubMedID: 19642642
Gene_locus related to this paper: torca-ACHE

Title : Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 23 :70 , 2008
Abstract :
PubMedSearch : Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70
PubMedID: 18341256

Title : A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods - Kassa_1999_Toxicology_132_111
Author(s) : Kassa J , Cabal J
Ref : Toxicology , 132 :111 , 1999
Abstract :
PubMedSearch : Kassa_1999_Toxicology_132_111
PubMedID: 10433374

Title : Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds - Cavaliere_1998_J.Toxicol.Clin.Toxicol_36_295
Author(s) : Cavaliere MJ , Puga FR , Calore EE , Calore NM , Pelegrino JR , da Rosa AR , Weg R
Ref : Journal of Toxicology Clinical Toxicology , 36 :295 , 1998
Abstract :
PubMedSearch : Cavaliere_1998_J.Toxicol.Clin.Toxicol_36_295
PubMedID: 9711194

Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237
Author(s) : Worek F , Widmann R , Knopff O , Szinicz L
Ref : Archives of Toxicology , 72 :237 , 1998
Abstract :
PubMedSearch : Worek_1998_Arch.Toxicol_72_237
PubMedID: 9587020

Title : A comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice - Kassa_1998_Acta.Medica_41_19
Author(s) : Kassa J
Ref : Acta Medica , 41 :19 , 1998
Abstract :
PubMedSearch : Kassa_1998_Acta.Medica_41_19
PubMedID: 9588068

Title : Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11 - Lallement_1998_Arch.Toxicol_72_84
Author(s) : Lallement G , Clarencon D , Masqueliez C , Baubichon D , Galonnier M , Burckhart MF , Peoc'h M , Mestries JC
Ref : Archives of Toxicology , 72 :84 , 1998
Abstract :
PubMedSearch : Lallement_1998_Arch.Toxicol_72_84
PubMedID: 9456079

Title : Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates - Ashani_1998_Biochem.Pharmacol_55_159
Author(s) : Ashani Y , Leader H , Rothschild N , Dosoretz C
Ref : Biochemical Pharmacology , 55 :159 , 1998
Abstract :
PubMedSearch : Ashani_1998_Biochem.Pharmacol_55_159
PubMedID: 9448738

Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466
Author(s) : Worek F , Backer M , Thiermann H , Szinicz L , Mast U , Klimmek R , Eyer P
Ref : Hum Exp Toxicol , 16 :466 , 1997
Abstract :
PubMedSearch : Worek_1997_Hum.Exp.Toxicol_16_466
PubMedID: 9292287

Title : The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice - Kassa_1997_Pharmacol.Toxicol_81_144
Author(s) : Kassa J , Bielavsky J
Ref : Pharmacol Toxicol , 81 :144 , 1997
Abstract :
PubMedSearch : Kassa_1997_Pharmacol.Toxicol_81_144
PubMedID: 9335072

Title : Chemical warfare. Nerve agent poisoning - Holstege_1997_Crit.Care.Clin_13_923
Author(s) : Holstege CP , Kirk M , Sidell FR
Ref : Critical Care Clinics , 13 :923 , 1997
Abstract :
PubMedSearch : Holstege_1997_Crit.Care.Clin_13_923
PubMedID: 9330846

Title : Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase - Masson_1997_Biochem.J_325_53
Author(s) : Masson P , Froment MT , Bartels CF , Lockridge O
Ref : Biochemical Journal , 325 :53 , 1997
Abstract :
PubMedSearch : Masson_1997_Biochem.J_325_53
PubMedID: 9224629

Title : Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates - Jokanovic_1996_Toxicol.Lett_85_35
Author(s) : Jokanovic M , Maksimovic M , Kilibarda V , Jovanovic D , Savic D
Ref : Toxicology Letters , 85 :35 , 1996
Abstract :
PubMedSearch : Jokanovic_1996_Toxicol.Lett_85_35
PubMedID: 8619258

Title : Phosphotriesterase, pralidoxime-2-chloride (2-PAM) and eptastigmine treatments and their combinations in DFP intoxication - Tuovinen_1996_Toxicol.Appl.Pharmacol_141_555
Author(s) : Tuovinen K , Kaliste-Korhonen E , Raushel FM , Hanninen O
Ref : Toxicology & Applied Pharmacology , 141 :555 , 1996
Abstract :
PubMedSearch : Tuovinen_1996_Toxicol.Appl.Pharmacol_141_555
PubMedID: 8975781

Title : Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae - Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391
Author(s) : Sanchez-Fortun S , Sanz F , Barahona MV
Ref : Archives of Environmental Contamination & Toxicology , 31 :391 , 1996
Abstract :
PubMedSearch : Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391
PubMedID: 8854833

Title : Acute organophosphate poisoning after disulfoton ingestion - Futagami_1995_J.Toxicol.Clin.Toxicol_33_151
Author(s) : Futagami K , Otsubo K , Nakao Y , Aoyama T , Iimori E , Urakami S , Ide M , Oishi R
Ref : Journal of Toxicology Clinical Toxicology , 33 :151 , 1995
Abstract :
PubMedSearch : Futagami_1995_J.Toxicol.Clin.Toxicol_33_151
PubMedID: 7897754

Title : Aldicarb poisoning. A case report with prolonged cholinesterase inhibition and improvement after pralidoxime therapy - Burgess_1994_Arch.Intern.Med_154_221
Author(s) : Burgess JL , Bernstein JN , Hurlbut K
Ref : Archives of Internal Medicine , 154 :221 , 1994
Abstract :
PubMedSearch : Burgess_1994_Arch.Intern.Med_154_221
PubMedID: 8285817

Title : In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human - Clement_1994_Arch.Toxicol_68_648
Author(s) : Clement JG , Erhardt N
Ref : Archives of Toxicology , 68 :648 , 1994
Abstract :
PubMedSearch : Clement_1994_Arch.Toxicol_68_648
PubMedID: 7857205

Title : Emergency care of insecticide poisonings - Hillman_1994_J.Florida.Med.Assoc_81_750
Author(s) : Hillman JV
Ref : Journal of the Florida Medical Association , 81 :750 , 1994
Abstract :
PubMedSearch : Hillman_1994_J.Florida.Med.Assoc_81_750
PubMedID: 7815041

Title : Study of respiratory failure in organophosphate and carbamate poisoning - Goswamy_1994_Heart.Lung_23_466
Author(s) : Goswamy R , Chaudhuri A , Mahashur AA
Ref : Heart & Lung , 23 :466 , 1994
Abstract :
PubMedSearch : Goswamy_1994_Heart.Lung_23_466
PubMedID: 7852061

Title : Primate performance decrements following acute soman exposure: failure of chemical countermeasures - Blick_1994_Pharmacol.Biochem.Behav_49_503
Author(s) : Blick DW , Murphy MR , Brown GC , Hartgraves SL
Ref : Pharmacology, Biochemistry & Behavior , 49 :503 , 1994
Abstract :
PubMedSearch : Blick_1994_Pharmacol.Biochem.Behav_49_503
PubMedID: 7862701

Title : Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate - Willems_1993_Arch.Toxicol_67_79
Author(s) : Willems JL , De Bisschop HC , Verstraete AG , Declerck C , Christiaens Y , Vanscheeuwyck P , Buylaert WA , Vogelaers D , Colardyn F
Ref : Archives of Toxicology , 67 :79 , 1993
Abstract :
PubMedSearch : Willems_1993_Arch.Toxicol_67_79
PubMedID: 8481105

Title : Organophosphate poisoning - Marrs_1993_Pharmacol.Ther58_51 || Marrs_1993_Pharmacol.Ther_58_51
Author(s) : Marrs TC
Ref : Pharmacol Ther , 58 :51 , 1993
Abstract :
PubMedSearch : Marrs_1993_Pharmacol.Ther58_51 || Marrs_1993_Pharmacol.Ther_58_51
PubMedID: 8415873

Title : [A study on acute organophosphorus poisoning--changes in the activity and isoenzyme patterns of serum cholinesterase in human poisoning]. [Japanese] - Yamanaka_1993_Japanese.J.Hyg_48_955
Author(s) : Yamanaka S , Yoshida M , Yamamura Y , Nishimura M , Takaesu Y
Ref : Nippon Eiseigaku Zasshi Japanese Journal of Hygiene , 48 :955 , 1993
Abstract :
PubMedSearch : Yamanaka_1993_Japanese.J.Hyg_48_955
PubMedID: 8107298

Title : Studies on the therapeutic effect of 2-pyridine aldoxime methiodide (2-PAM) in mammals following organophosphorus compound-poisoning (report III): distribution and antidotal effect of 2-PAM in rats - Uehara_1993_J.Toxicol.Sci_18_265
Author(s) : Uehara S , Hiromori T , Isobe N , Suzuki T , Kato T , Miyamoto J
Ref : Journal of Toxicological Sciences , 18 :265 , 1993
Abstract :
PubMedSearch : Uehara_1993_J.Toxicol.Sci_18_265
PubMedID: 8295230

Title : The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats - Anderson_1992_Drug.Chem.Toxicol_15_285
Author(s) : Anderson DR , Harris LW , Woodard CL , Lennox WJ
Ref : Drug & Chemical Toxicology , 15 :285 , 1992
Abstract :
PubMedSearch : Anderson_1992_Drug.Chem.Toxicol_15_285
PubMedID: 1459041

Title : A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning - Shih_1991_Toxicol.Lett_55_131
Author(s) : Shih TM , Whalley CE , Valdes JJ
Ref : Toxicology Letters , 55 :131 , 1991
Abstract :
PubMedSearch : Shih_1991_Toxicol.Lett_55_131
PubMedID: 1998202

Title : Protection from lethality and behavioral incapacitation resulting from intoxication by soman (pinacolyl methylphosphonofluoridate) and treatment with atropine sulfate and 2-PAM chloride in the guinea pig, cavia porcellus - Romano_1991_Drug.Chem.Toxicol_14_21
Author(s) : Romano JA, Jr. , Terry MR , Murrow ML , Mays MZ
Ref : Drug & Chemical Toxicology , 14 :21 , 1991
Abstract :
PubMedSearch : Romano_1991_Drug.Chem.Toxicol_14_21
PubMedID: 1889376

Title : HI-6 and 2-PAM in sheep: pharmacokinetics and effects on muscle tissue following intramuscular injection - Moore_1991_Biopharm.Drug.Dispos_12_223
Author(s) : Moore DH , Hayward IJ , Tucker FS , Lukey B
Ref : Biopharmaceutics & Drug Disposition , 12 :223 , 1991
Abstract :
PubMedSearch : Moore_1991_Biopharm.Drug.Dispos_12_223
PubMedID: 2059672

Title : Pharmacokinetics and pharmacodynamics of oximes in unanesthetized pigs - Stemler_1991_Fundam.Appl.Toxicol_16_548
Author(s) : Stemler FW , Tezak-Reid TM , McCluskey MP , Kaminskis A , Corcoran KD , Shih ML , Stewart JR , Wade JV , Hayward IJ
Ref : Fundamental & Applied Toxicology , 16 :548 , 1991
Abstract :
PubMedSearch : Stemler_1991_Fundam.Appl.Toxicol_16_548
PubMedID: 1855625

Title : Disposition and metabolism of acetylcholinesterase reactivators 2PAM-I, TMB4 and R665 in rats submitted to organophosphate poisoning - Garrigue_1991_Xenobiotica_21_583
Author(s) : Garrigue H , Maurizis JC , Madelmont JC , Nicolas C , Meyniel JM , Louvel A , Demerseman P , Sentenac-Roumanou H , Veyre A
Ref : Xenobiotica , 21 :583 , 1991
Abstract :
PubMedSearch : Garrigue_1991_Xenobiotica_21_583
PubMedID: 1949891

Title : Use of glycopyrrolate and atropine in acute organophosphorus poisoning - Tracey_1990_Hum.Exp.Toxicol_9_99
Author(s) : Tracey JA , Gallagher H
Ref : Hum Exp Toxicol , 9 :99 , 1990
Abstract :
PubMedSearch : Tracey_1990_Hum.Exp.Toxicol_9_99
PubMedID: 2340198

Title : Use of continuous infusion of pralidoxime for treatment of organophosphate poisoning in children -
Author(s) : Farrar HC , Wells TG , Kearns GL
Ref : Journal of Pediatrics , 116 :658 , 1990
PubMedID: 2319410

Title : Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates - Hanke_1990_J.Appl.Toxicol_10_87
Author(s) : Hanke DW , Beckett MS , Overton MA , Burdick CK , Lieske CN
Ref : Journal of Applied Toxicology , 10 :87 , 1990
Abstract :
PubMedSearch : Hanke_1990_J.Appl.Toxicol_10_87
PubMedID: 2362084

Title : Heat exchange after cholinolytic and oxime therapy in protective clothing - Kolka_1990_Mil.Med_155_390
Author(s) : Kolka MA , Cadarette BS
Ref : Mil Med , 155 :390 , 1990
Abstract :
PubMedSearch : Kolka_1990_Mil.Med_155_390
PubMedID: 2120621

Title : Use of pralidoxime-Pd(II) complex for the spectrophotometric determination of the cholinesterase reactivator (PAM-2Cl) in the urine - Karljikovic-Rajic_1990_Clin.Chim.Acta_193_119
Author(s) : Karljikovic-Rajic KD , Stankovic BS
Ref : Clinica Chimica Acta , 193 :119 , 1990
Abstract :
PubMedSearch : Karljikovic-Rajic_1990_Clin.Chim.Acta_193_119
PubMedID: 2282690

Title : Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning - Garrigue_1990_Xenobiotica_20_699
Author(s) : Garrigue H , Maurizis JC , Nicolas C , Madelmont JC , Godeneche D , Hulot T , Morge X , Demerseman P , Sentenac-Roumanou H , Veyre A
Ref : Xenobiotica , 20 :699 , 1990
Abstract :
PubMedSearch : Garrigue_1990_Xenobiotica_20_699
PubMedID: 2146816

Title : A new H-oxime restores rat diaphragm contractility after esterase inhibition in vitro - Alberts_1990_Eur.J.Pharmacol_184_191
Author(s) : Alberts P
Ref : European Journal of Pharmacology , 184 :191 , 1990
Abstract :
PubMedSearch : Alberts_1990_Eur.J.Pharmacol_184_191
PubMedID: 2209712

Title : Disposition kinetics of 2-pyridine aldoxime methochloride in Bubalus bubalis -
Author(s) : Srivastava AK , Malik JK
Ref : Journal of Veterinary Pharmacology & Therapeutics , 12 :103 , 1989
PubMedID: 2704055

Title : Ligand stabilization of cholinesterases - Payne_1989_Biochim.Biophys.Acta_999_46
Author(s) : Payne CS , Saeed M , Wolfe AD
Ref : Biochimica & Biophysica Acta , 999 :46 , 1989
Abstract :
PubMedSearch : Payne_1989_Biochim.Biophys.Acta_999_46
PubMedID: 2804138

Title : Effects of soman and its antidotes on tracheal mucociliary transport of ferrets - Marin_1989_J.App.Physio_66_1390
Author(s) : Marin MG , Zwierzynski D , McBride RK , Culp DJ
Ref : Journal of Applied Physiology , 66 :1390 , 1989
Abstract :
PubMedSearch : Marin_1989_J.App.Physio_66_1390
PubMedID: 2496095

Title : The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication - Harris_1989_Toxicol.Appl.Pharmacol_98_128
Author(s) : Harris LW , Talbot BG , Lennox WJ , Anderson DR
Ref : Toxicology & Applied Pharmacology , 98 :128 , 1989
Abstract :
PubMedSearch : Harris_1989_Toxicol.Appl.Pharmacol_98_128
PubMedID: 2494778

Title : Edrophonium and pralidoxime [letter] -
Author(s) : Alston TA
Ref : Anesthesia & Analgesia , 68 :826 , 1989
PubMedID: 2735555

Title : Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice - Kaliste-Korhonen_1989_Gen.Pharmacol_20_805
Author(s) : Kaliste-Korhonen E , Ryhanen R , Ylitalo P , Hanninen O
Ref : General Pharmacology , 20 :805 , 1989
Abstract :
PubMedSearch : Kaliste-Korhonen_1989_Gen.Pharmacol_20_805
PubMedID: 2687080

Title : Combined atropine and 2-PAM Cl effects on tracking performance and visual, physiological, and psychological functions - Penetar_1988_Aviat.Space.Environ.Med_59_1125
Author(s) : Penetar DM , Haegerstrom-Portnoy G , Jones RT
Ref : Aviat Space Environ Med , 59 :1125 , 1988
Abstract :
PubMedSearch : Penetar_1988_Aviat.Space.Environ.Med_59_1125
PubMedID: 3240212

Title : Toxicity of an acute dose of agent VX and other organophosphorus esters in the chicken - Wilson_1988_J.Toxicol.Environ.Health_23_103
Author(s) : Wilson BW , Henderson JD , Chow E , Schreider J , Goldman M , Culbertson R , Dacre JC
Ref : J Toxicol Environ Health , 23 :103 , 1988
Abstract :
PubMedSearch : Wilson_1988_J.Toxicol.Environ.Health_23_103
PubMedID: 3336055

Title : Kinetic investigations into the interactions of aprophen with cholinesterases and a carboxylesterase - Rush_1986_Biochem.Pharmacol_35_4167
Author(s) : Rush RS , Doctor BP , Wolfe AD
Ref : Biochemical Pharmacology , 35 :4167 , 1986
Abstract :
PubMedSearch : Rush_1986_Biochem.Pharmacol_35_4167
PubMedID: 3098245

Title : Studies on the toxicity, metabolism, and anticholinesterase properties of acephate and methamidophos - Hussain_1985_J.Env.Sci.Health_20_129
Author(s) : Hussain MA , Mohamad RB , Oloffs PC
Ref : Journal of Environmental Science & Health Part B: Pesticides, Food Contaminants, & Agricultural Wastes , 20 :129 , 1985
Abstract :
PubMedSearch : Hussain_1985_J.Env.Sci.Health_20_129
PubMedID: 3989221

Title : Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites - Martin_1985_J.Neurol.Sci_71_1
Author(s) : Martin LJ , Doebler JA , Anthony A
Ref : Journal of the Neurological Sciences , 71 :1 , 1985
Abstract :
PubMedSearch : Martin_1985_J.Neurol.Sci_71_1
PubMedID: 2418157

Title : Reactivation of ethyl methylphosphonylated eel acetylcholinesterase in vitro by 2PAM, H16, and a series of nonquaternary alpha-ketothiohydroximates -
Author(s) : Kenley RA , Bedford CD , Howd RA , Jackson SE
Ref : Biochemical Pharmacology , 34 :3606 , 1985
PubMedID: 4052103

Title : Clinical observation and comparison of the effectiveness of several oxime cholinesterase reactivators - Xue_1985_Scand.J.Work.Environ.Health_4_46
Author(s) : Xue SZ , Ding XJ , Ding Y
Ref : Scandinavian Journal of Work, Environment & Health , 4 :46 , 1985
Abstract :
PubMedSearch : Xue_1985_Scand.J.Work.Environ.Health_4_46
PubMedID: 3914075

Title : PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning - Boskovic_1984_Fundam.Appl.Toxicol_4_S106
Author(s) : Boskovic B , Kovacevic V , Jovanovic D
Ref : Fundamental & Applied Toxicology , 4 :S106 , 1984
Abstract :
PubMedSearch : Boskovic_1984_Fundam.Appl.Toxicol_4_S106
PubMedID: 6724203

Title : Chemical reactivations of inactivated acetylcholinesterase after 2-PAM therapy in fenitrothion-poisoned rat and rabbit - Matsubara_1984_J.Pharmacobio.Dynamics_7_131
Author(s) : Matsubara T , Horikoshi I
Ref : Journal of Pharmacobio Dynamics , 7 :131 , 1984
Abstract :
PubMedSearch : Matsubara_1984_J.Pharmacobio.Dynamics_7_131
PubMedID: 6726618

Title : Nonquaternary cholinesterase reactivators. 2. Alpha-heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro - Kenley_1984_J.Med.Chem_27_1201
Author(s) : Kenley RA , Bedford CD , Dailey OD, Jr. , Howd RA , Miller A
Ref : Journal of Medicinal Chemistry , 27 :1201 , 1984
Abstract :
PubMedSearch : Kenley_1984_J.Med.Chem_27_1201
PubMedID: 6471073

Title : [Neurophysiologic study of the effect of 2PAM-Cl on the neuromuscular junction]. [Serbo-Croatian (Roman)] -
Author(s) : Stamenovic BA
Ref : Vojnosanitetski Pregled , 41 :326 , 1984
PubMedID: 6516240

Title : [Effects of organophosphorus compounds and PAM on cholinesterase activity in rat tissues]. [Japanese] -
Author(s) : Yamanaka S , Nishimura M
Ref : Nippon Eiseigaku Zasshi Japanese Journal of Hygiene , 39 :795 , 1984
PubMedID: 6533340

Title : Reactivation of VX-inhibited cholinesterase by 2-PAM and HS-6 in rats - Harris_1983_Drug.Chem.Toxicol_6_235
Author(s) : Harris LW , Stitcher DL
Ref : Drug & Chemical Toxicology , 6 :235 , 1983
Abstract :
PubMedSearch : Harris_1983_Drug.Chem.Toxicol_6_235
PubMedID: 6628257

Title : Brain neuronal RNA metabolism during acute soman toxication: effects of antidotal pretreatments - Doebler_1983_Neurochem.Res_8_997
Author(s) : Doebler JA , Bocan TM , Moore RA , Shih TM , Anthony A
Ref : Neurochemical Research , 8 :997 , 1983
Abstract :
PubMedSearch : Doebler_1983_Neurochem.Res_8_997
PubMedID: 6194444

Title : Efficacy and toxicity of drug combinations in treatment of physostigmine toxicosis - Klemm_1983_Toxicology_27_41
Author(s) : Klemm WR
Ref : Toxicology , 27 :41 , 1983
Abstract :
PubMedSearch : Klemm_1983_Toxicology_27_41
PubMedID: 6149635

Title : Differential effects of di-isopropylfluorophosphate poisoning and its treatment on opioid antinociception in the mouse - Kitchen_1983_Life.Sci_1_669
Author(s) : Kitchen I , Green PG
Ref : Life Sciences , 1 :669 , 1983
Abstract :
PubMedSearch : Kitchen_1983_Life.Sci_1_669
PubMedID: 6664242

Title : [Effect of some reactivators on cholinesterase activity in the chromodacryorrhea test in rats]. [Bulgarian] - Naneva_1976_Vet.Med.Nauki_13_81
Author(s) : Naneva E
Ref : Veterinarno Meditsinski Nauki , 13 :81 , 1976
Abstract :
PubMedSearch : Naneva_1976_Vet.Med.Nauki_13_81
PubMedID: 799866

Title : Reactivation studies on organophosphate inhibited human cholinesterases by pralidoxime (P-2-AM) - Ganendran_1976_Southeast.Asian.J.Trop.Med.Public.Health_7_417
Author(s) : Ganendran A , Balabaskaran S
Ref : Southeast Asian J Trop Med Public Health , 7 :417 , 1976
Abstract :
PubMedSearch : Ganendran_1976_Southeast.Asian.J.Trop.Med.Public.Health_7_417
PubMedID: 1030845

Title : Pralidoxime as an insignificant reactivator in severe anticholinesterase (organophosphate insecticide) poisoning - Ganendran_1976_Southeast.Asian.J.Trop.Med.Public.Health_7_543
Author(s) : Ganendran A , Balabaskaran S
Ref : Southeast Asian J Trop Med Public Health , 7 :543 , 1976
Abstract :
PubMedSearch : Ganendran_1976_Southeast.Asian.J.Trop.Med.Public.Health_7_543
PubMedID: 1030852

Title : Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form - Shek_1976_J.Med.Chem_19_113
Author(s) : Shek E , Higuchi T , Bodor N
Ref : Journal of Medicinal Chemistry , 19 :113 , 1976
Abstract :
PubMedSearch : Shek_1976_J.Med.Chem_19_113
PubMedID: 1246032

Title : [Protective action of pralidoxime against the teratogenic effects of parathion on the axial skeleton of the quail embryo]. [French] -
Author(s) : Meiniel R
Ref : Comptes Rendus de l Academie des Sciences , 279 :603 , 1974
PubMedID: 4216430

Title : Toxogonin and pralidoxime: kinetic comparison after intravenous administration to man -
Author(s) : Sidell FR , Groff WA , Kaminskis A
Ref : Journal of Pharmaceutical Sciences , 61 :1765 , 1972
PubMedID: 4569114

Title : [Inhibition of acetylcholinesterase and cholinesterase by pyridinium oximes] -
Author(s) : Zech R
Ref : Hoppe-Seylers Zeitschrift fur physiologische Chemie , 350 :1415 , 1969
PubMedID: 5362616

Title : The reactivation by oximes and hydroxamic acids of cholinesterases inhibited by organophosphorus compounds -
Author(s) : Childs AF , Davies DR , Green AL , Rutland JP
Ref : British Journal of Pharmacology , 10 :462 , 1955
PubMedID: 13276605

Title : Reactivation of acetylcholinesterase inhibited by alkyl phosphates -
Author(s) : Wilson IB , Ginsburg S
Ref : Archives of Biochemistry & Biophysics , 54 :569 , 1955
PubMedID: