| Title : Allosteric mechanisms of signal transduction - Changeux_2005_Science_308_1424 |
| Author(s) : Changeux JP , Edelstein SJ |
| Ref : Science , 308 :1424 , 2005 |
|
Abstract :
Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation. |
| PubMedSearch : Changeux_2005_Science_308_1424 |
| PubMedID: 15933191 |
Changeux JP, Edelstein SJ (2005)
Allosteric mechanisms of signal transduction
Science
308 :1424
Changeux JP, Edelstein SJ (2005)
Science
308 :1424