| Title : Increased number of high-affinity muscarinic receptors in rat heart after phenylhydrazine treatment - Chatelain_1983_Eur.J.Pharmacol_91_279 |
| Author(s) : Chatelain P , Waelbroeck M , de Neef P , Robberecht P , Christophe J |
| Ref : European Journal of Pharmacology , 91 :279 , 1983 |
|
Abstract :
The effect of phenylhydrazine-induced heart hypertrophy on muscarinic cholinergic binding sites was studied in heart membranes by determining total (with [3H]NMS) and high-affinity (with [3H]Oxo-M) binding sites and estimating low-affinity binding sites by difference. Phenylhydrazine induced an increased concentration of high-affinity binding sites without affecting the concentration of low-affinity binding sites. The KD values for the ligands were unaffected. |
| PubMedSearch : Chatelain_1983_Eur.J.Pharmacol_91_279 |
| PubMedID: 6225652 |
Chatelain P, Waelbroeck M, de Neef P, Robberecht P, Christophe J (1983)
Increased number of high-affinity muscarinic receptors in rat heart after phenylhydrazine treatment
European Journal of Pharmacology
91 :279
Chatelain P, Waelbroeck M, de Neef P, Robberecht P, Christophe J (1983)
European Journal of Pharmacology
91 :279