| Title : Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes - Chen_2007_Bioorg.Med.Chem.Lett_17_5853 |
| Author(s) : Chen P , Caldwell CG , Mathvink RJ , Leiting B , Marsilio F , Patel RA , Wu JK , He H , Lyons KA , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5853 , 2007 |
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Abstract :
A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC(50) values as low as 5.8 nM for inhibition of DPP-4. |
| PubMedSearch : Chen_2007_Bioorg.Med.Chem.Lett_17_5853 |
| PubMedID: 17869513 |
Chen P, Caldwell CG, Mathvink RJ, Leiting B, Marsilio F, Patel RA, Wu JK, He H, Lyons KA, Thornberry NA, Weber AE (2007)
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
Bioorganic & Medicinal Chemistry Lett
17 :5853
Chen P, Caldwell CG, Mathvink RJ, Leiting B, Marsilio F, Patel RA, Wu JK, He H, Lyons KA, Thornberry NA, Weber AE (2007)
Bioorganic & Medicinal Chemistry Lett
17 :5853