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References (28)

Title : A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice - Berger_2018_Endocrinol.Diabetes.Metab_1_e00002
Author(s) : Berger JP , SinhaRoy R , Pocai A , Kelly TM , Scapin G , Gao YD , Pryor KAD , Wu JK , Eiermann GJ , Xu SS , Zhang X , Tatosian DA , Weber AE , Thornberry NA , Carr RD
Ref : Endocrinol Diabetes Metab , 1 :e00002 , 2018
Abstract : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002
ESTHER : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002
PubMedSearch : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002
PubMedID: 30815539
Gene_locus related to this paper: human-DPP4

Title : The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors - Cox_2016_Bioorg.Med.Chem.Lett_26_2622
Author(s) : Cox JM , Chu HD , Kuethe JT , Gao YD , Scapin G , Eiermann G , He H , Li X , Lyons KA , Metzger J , Petrov A , Wu JK , Xu S , Sinha-Roy R , Weber AE , Biftu T
Ref : Bioorganic & Medicinal Chemistry Lett , 26 :2622 , 2016
Abstract : Cox_2016_Bioorg.Med.Chem.Lett_26_2622
ESTHER : Cox_2016_Bioorg.Med.Chem.Lett_26_2622
PubMedSearch : Cox_2016_Bioorg.Med.Chem.Lett_26_2622
PubMedID: 27106708
Gene_locus related to this paper: human-DPP4

Title : Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes - Biftu_2014_J.Med.Chem_57_3205
Author(s) : Biftu T , Sinha-Roy R , Chen P , Qian X , Feng D , Kuethe JT , Scapin G , Gao YD , Yan Y , Krueger D , Bak A , Eiermann G , He J , Cox J , Hicks J , Lyons K , He H , Salituro G , Tong S , Patel S , Doss G , Petrov A , Wu J , Xu SS , Sewall C , Zhang X , Zhang B , Thornberry NA , Weber AE
Ref : Journal of Medicinal Chemistry , 57 :3205 , 2014
Abstract : Biftu_2014_J.Med.Chem_57_3205
ESTHER : Biftu_2014_J.Med.Chem_57_3205
PubMedSearch : Biftu_2014_J.Med.Chem_57_3205
PubMedID: 24660890
Gene_locus related to this paper: human-DPP4

Title : Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors - Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097
Author(s) : Edmondson SD , Mastracchio A , Cox JM , Eiermann GJ , He H , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Xu S , Zhu B , Thornberry NA , Roy RS , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4097 , 2009
Abstract : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097
ESTHER : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097
PubMedSearch : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097
PubMedID: 19539471
Gene_locus related to this paper: human-DPP4

Title : Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors - Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409
Author(s) : Edmondson SD , Wei L , Xu J , Shang J , Xu S , Pang J , Chaudhary A , Dean DC , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Scapin G , Wu JK , Beconi MG , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2409 , 2008
Abstract : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409
ESTHER : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409
PubMedSearch : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409
PubMedID: 18331795
Gene_locus related to this paper: human-DPP4

Title : Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design - Liang_2008_Bioorg.Med.Chem.Lett_18_3706
Author(s) : Liang GB , Qian X , Biftu T , Singh S , Gao YD , Scapin G , Patel S , Leiting B , Patel R , Wu J , Zhang X , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :3706 , 2008
Abstract : Liang_2008_Bioorg.Med.Chem.Lett_18_3706
ESTHER : Liang_2008_Bioorg.Med.Chem.Lett_18_3706
PubMedSearch : Liang_2008_Bioorg.Med.Chem.Lett_18_3706
PubMedID: 18524582
Gene_locus related to this paper: human-DPP4

Title : Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines - Kim_2008_J.Med.Chem_51_589
Author(s) : Kim D , Kowalchick JE , Brockunier LL , Parmee ER , Eiermann GJ , Fisher MH , He H , Leiting B , Lyons K , Scapin G , Patel SB , Petrov A , Pryor KD , Roy RS , Wu JK , Zhang X , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE
Ref : Journal of Medicinal Chemistry , 51 :589 , 2008
Abstract : Kim_2008_J.Med.Chem_51_589
ESTHER : Kim_2008_J.Med.Chem_51_589
PubMedSearch : Kim_2008_J.Med.Chem_51_589
PubMedID: 18201067

Title : Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors - Cox_2007_Bioorg.Med.Chem.Lett_17_4579
Author(s) : Cox JM , Harper B , Mastracchio A , Leiting B , Sinha Roy R , Patel RA , Wu JK , Lyons KA , He H , Xu S , Zhu B , Thornberry NA , Weber AE , Edmondson SD
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :4579 , 2007
Abstract : Cox_2007_Bioorg.Med.Chem.Lett_17_4579
ESTHER : Cox_2007_Bioorg.Med.Chem.Lett_17_4579
PubMedSearch : Cox_2007_Bioorg.Med.Chem.Lett_17_4579
PubMedID: 17562364

Title : Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Thornberry_2007_Curr.Top.Med.Chem_7_557
Author(s) : Thornberry NA , Weber AE
Ref : Curr Top Med Chem , 7 :557 , 2007
Abstract : Thornberry_2007_Curr.Top.Med.Chem_7_557
ESTHER : Thornberry_2007_Curr.Top.Med.Chem_7_557
PubMedSearch : Thornberry_2007_Curr.Top.Med.Chem_7_557
PubMedID: 17352677

Title : Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors - Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934
Author(s) : Kowalchick JE , Leiting B , Pryor KD , Marsilio F , Wu JK , He H , Lyons KA , Eiermann GJ , Petrov A , Scapin G , Patel RA , Thornberry NA , Weber AE , Kim D
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5934 , 2007
Abstract : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934
ESTHER : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934
PubMedSearch : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934
PubMedID: 17827003
Gene_locus related to this paper: human-DPP4

Title : 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV - Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806
Author(s) : Kaelin DE , Smenton AL , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE , Duffy JL
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5806 , 2007
Abstract : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806
ESTHER : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806
PubMedSearch : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806
PubMedID: 17851076
Gene_locus related to this paper: human-DPP4

Title : Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes - Chen_2007_Bioorg.Med.Chem.Lett_17_5853
Author(s) : Chen P , Caldwell CG , Mathvink RJ , Leiting B , Marsilio F , Patel RA , Wu JK , He H , Lyons KA , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5853 , 2007
Abstract : Chen_2007_Bioorg.Med.Chem.Lett_17_5853
ESTHER : Chen_2007_Bioorg.Med.Chem.Lett_17_5853
PubMedSearch : Chen_2007_Bioorg.Med.Chem.Lett_17_5853
PubMedID: 17869513

Title : Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors - Gao_2007_Bioorg.Med.Chem.Lett_17_3877
Author(s) : Gao YD , Feng D , Sheridan RP , Scapin G , Patel SB , Wu JK , Zhang X , Sinha-Roy R , Thornberry NA , Weber AE , Biftu T
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3877 , 2007
Abstract : Gao_2007_Bioorg.Med.Chem.Lett_17_3877
ESTHER : Gao_2007_Bioorg.Med.Chem.Lett_17_3877
PubMedSearch : Gao_2007_Bioorg.Med.Chem.Lett_17_3877
PubMedID: 17502141

Title : (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)- 1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Biftu_2007_Bioorg.Med.Chem.Lett_17_49
Author(s) : Biftu T , Feng D , Qian X , Liang GB , Kieczykowski G , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Scapin G , Patel S , Gao YD , Singh S , Wu J , Zhang X , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :49 , 2007
Abstract : Biftu_2007_Bioorg.Med.Chem.Lett_17_49
ESTHER : Biftu_2007_Bioorg.Med.Chem.Lett_17_49
PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_49
PubMedID: 17055272
Gene_locus related to this paper: human-DPP4

Title : Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin - Biftu_2007_Bioorg.Med.Chem.Lett_17_3384
Author(s) : Biftu T , Scapin G , Singh S , Feng D , Becker JW , Eiermann G , He H , Lyons K , Patel S , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Doss GA , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3384 , 2007
Abstract : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384
ESTHER : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384
PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384
PubMedID: 17433672
Gene_locus related to this paper: human-DPP4

Title : 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV - Duffy_2007_Bioorg.Med.Chem.Lett_17_2879
Author(s) : Duffy JL , Kirk BA , Wang L , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2879 , 2007
Abstract : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879
ESTHER : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879
PubMedSearch : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879
PubMedID: 17350841
Gene_locus related to this paper: human-DPP4

Title : Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes - Liang_2007_Bioorg.Med.Chem.Lett_17_1903
Author(s) : Liang GB , Qian X , Feng D , Biftu T , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :1903 , 2007
Abstract : Liang_2007_Bioorg.Med.Chem.Lett_17_1903
ESTHER : Liang_2007_Bioorg.Med.Chem.Lett_17_1903
PubMedSearch : Liang_2007_Bioorg.Med.Chem.Lett_17_1903
PubMedID: 17291750

Title : Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate) - Kim_2007_Bioorg.Med.Chem.Lett_17_3373
Author(s) : Kim D , Kowalchick JE , Edmondson SD , Mastracchio A , Xu J , Eiermann GJ , Leiting B , Wu JK , Pryor KD , Patel RA , He H , Lyons KA , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3373 , 2007
Abstract : Kim_2007_Bioorg.Med.Chem.Lett_17_3373
ESTHER : Kim_2007_Bioorg.Med.Chem.Lett_17_3373
PubMedSearch : Kim_2007_Bioorg.Med.Chem.Lett_17_3373
PubMedID: 17434732

Title : Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors - Xu_2006_Bioorg.Med.Chem.Lett_16_1346
Author(s) : Xu J , Wei L , Mathvink R , Edmondson SD , Mastracchio A , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Petrov A , Wu JK , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :1346 , 2006
Abstract : Xu_2006_Bioorg.Med.Chem.Lett_16_1346
ESTHER : Xu_2006_Bioorg.Med.Chem.Lett_16_1346
PubMedSearch : Xu_2006_Bioorg.Med.Chem.Lett_16_1346
PubMedID: 16332437

Title : (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Edmondson_2006_J.Med.Chem_49_3614
Author(s) : Edmondson SD , Mastracchio A , Mathvink RJ , He J , Harper B , Park YJ , Beconi M , Di Salvo J , Eiermann GJ , He H , Leiting B , Leone JF , Levorse DA , Lyons K , Patel RA , Patel SB , Petrov A , Scapin G , Shang J , Roy RS , Smith A , Wu JK , Xu S , Zhu B , Thornberry NA , Weber AE
Ref : Journal of Medicinal Chemistry , 49 :3614 , 2006
Abstract : Edmondson_2006_J.Med.Chem_49_3614
ESTHER : Edmondson_2006_J.Med.Chem_49_3614
PubMedSearch : Edmondson_2006_J.Med.Chem_49_3614
PubMedID: 16759103
Gene_locus related to this paper: human-DPP4

Title : Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors - Xu_2006_Bioorg.Med.Chem.Lett_16_5373
Author(s) : Xu J , Wei L , Mathvink RJ , Edmondson SD , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5373 , 2006
Abstract : Xu_2006_Bioorg.Med.Chem.Lett_16_5373
ESTHER : Xu_2006_Bioorg.Med.Chem.Lett_16_5373
PubMedSearch : Xu_2006_Bioorg.Med.Chem.Lett_16_5373
PubMedID: 16919457
Gene_locus related to this paper: human-DPP4

Title : Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors - Edmondson_2005_Bioorg.Med.Chem.Lett_15_3048
Author(s) : Edmondson SD , Mastracchio A , Duffy JL , Eiermann GJ , He H , Ita I , Leiting B , Leone JF , Lyons KA , Makarewicz AM , Patel RA , Petrov A , Wu JK , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :3048 , 2005
Abstract : Edmondson_2005_Bioorg.Med.Chem.Lett_15_3048
ESTHER : Edmondson_2005_Bioorg.Med.Chem.Lett_15_3048
PubMedSearch : Edmondson_2005_Bioorg.Med.Chem.Lett_15_3048
PubMedID: 15908206

Title : Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors - Xu_2005_Bioorg.Med.Chem.Lett_15_2533
Author(s) : Xu J , Wei L , Mathvink R , He J , Park YJ , He H , Leiting B , Lyons KA , Marsilio F , Patel RA , Wu JK , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2533 , 2005
Abstract : Xu_2005_Bioorg.Med.Chem.Lett_15_2533
ESTHER : Xu_2005_Bioorg.Med.Chem.Lett_15_2533
PubMedSearch : Xu_2005_Bioorg.Med.Chem.Lett_15_2533
PubMedID: 15863311

Title : (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Kim_2005_J.Med.Chem_48_141
Author(s) : Kim D , Wang L , Beconi M , Eiermann GJ , Fisher MH , He H , Hickey GJ , Kowalchick JE , Leiting B , Lyons K , Marsilio F , McCann ME , Patel RA , Petrov A , Scapin G , Patel SB , Roy RS , Wu JK , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE
Ref : Journal of Medicinal Chemistry , 48 :141 , 2005
Abstract : Kim_2005_J.Med.Chem_48_141
ESTHER : Kim_2005_J.Med.Chem_48_141
PubMedSearch : Kim_2005_J.Med.Chem_48_141
PubMedID: 15634008
Gene_locus related to this paper: human-DPP4

Title : Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole - Ashton_2005_Bioorg.Med.Chem.Lett_15_2253
Author(s) : Ashton WT , Sisco RM , Dong H , Lyons KA , He H , Doss GA , Leiting B , Patel RA , Wu JK , Marsilio F , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2253 , 2005
Abstract : Ashton_2005_Bioorg.Med.Chem.Lett_15_2253
ESTHER : Ashton_2005_Bioorg.Med.Chem.Lett_15_2253
PubMedSearch : Ashton_2005_Bioorg.Med.Chem.Lett_15_2253
PubMedID: 15837304

Title : Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9 - Lankas_2005_Diabetes_54_2988
Author(s) : Lankas GR , Leiting B , Roy RS , Eiermann GJ , Beconi MG , Biftu T , Chan CC , Edmondson S , Feeney WP , He H , Ippolito DE , Kim D , Lyons KA , Ok HO , Patel RA , Petrov AN , Pryor KA , Qian X , Reigle L , Woods A , Wu JK , Zaller D , Zhang X , Zhu L , Weber AE , Thornberry NA
Ref : Diabetes , 54 :2988 , 2005
Abstract : Lankas_2005_Diabetes_54_2988
ESTHER : Lankas_2005_Diabetes_54_2988
PubMedSearch : Lankas_2005_Diabetes_54_2988
PubMedID: 16186403

Title : Potent and selective proline derived dipeptidyl peptidase IV inhibitors - Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151
Author(s) : Edmondson SD , Mastracchio A , Beconi M , Colwell LF, Jr. , Habulihaz B , He H , Kumar S , Leiting B , Lyons KA , Mao A , Marsilio F , Patel RA , Wu JK , Zhu L , Thornberry NA , Weber AE , Parmee ER
Ref : Bioorganic & Medicinal Chemistry Lett , 14 :5151 , 2004
Abstract : Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151
ESTHER : Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151
PubMedSearch : Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151
PubMedID: 15380217

Title : 4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors - Parmee_2004_Bioorg.Med.Chem.Lett_14_43
Author(s) : Parmee ER , He J , Mastracchio A , Edmondson SD , Colwell L , Eiermann G , Feeney WP , Habulihaz B , He H , Kilburn R , Leiting B , Lyons K , Marsilio F , Patel RA , Petrov A , Di Salvo J , Wu JK , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 14 :43 , 2004
Abstract : Parmee_2004_Bioorg.Med.Chem.Lett_14_43
ESTHER : Parmee_2004_Bioorg.Med.Chem.Lett_14_43
PubMedSearch : Parmee_2004_Bioorg.Med.Chem.Lett_14_43
PubMedID: 14684294