Cummings_2000_Am.J.Geriatr.Psychiatry_8_134

Reference

Title : The relationship between donepezil and behavioral disturbances in patients with Alzheimer's disease - Cummings_2000_Am.J.Geriatr.Psychiatry_8_134
Author(s) : Cummings JL , Donohue JA , Brooks RL
Ref : American Journal of Geriatry & Psychiatry , 8 :134 , 2000
Abstract : The authors tested the hypothesis that behavioral disturbances are reported at significantly lower rates by caregivers of Alzheimer's disease (AD) patients receiving the antidementia drug donepezil, compared with a group of patients receiving no antidementia drug treatment. Patients administered donepezilfor 6 months (n=84) were compared with patients not on donepezil (n=248). Patients taking donepezil had significantly lower levels of behavioral disturbances than patients not receiving this agent (P< or =0.011). Specifically, donepezil patients were described as significantly (P< or =0.05) less likely to be threatening, destroy property, and talk loudly. Also, significantly fewer patients receiving donepezil were treated with sedatives (P< or =0.005). These findings support the growing body of evidence that cholinesterase inhibitors have psychotropic properties and reduce behavioral disturbances in patients with AD.
ESTHER : Cummings_2000_Am.J.Geriatr.Psychiatry_8_134
PubMedSearch : Cummings_2000_Am.J.Geriatr.Psychiatry_8_134
PubMedID: 10804074

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Citations formats

Cummings JL, Donohue JA, Brooks RL (2000)
The relationship between donepezil and behavioral disturbances in patients with Alzheimer's disease
American Journal of Geriatry & Psychiatry 8 :134

Cummings JL, Donohue JA, Brooks RL (2000)
American Journal of Geriatry & Psychiatry 8 :134