Aricept~Donepezil~E2020
Treatment of Alzheimer Disease, trademark is Aricept || Reversible inhibitor of AChE but not of BChE || Donepezil highly and selectively inhibits AChE (IC50: 6.7 nM) more than BuChE (IC50: 7.4 microM)
General
Type : Derivative of Donepezil, Piperidine, Drug, Inden
Chemical_Nomenclature : 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one\;hydrochloride
Canonical SMILES : COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
InChI : InChI=1S\/C24H29NO3.ClH\/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18\;\/h3-7,14-15,17,20H,8-13,16H2,1-2H3\;1H
InChIKey : XWAIAVWHZJNZQQ-UHFFFAOYSA-N
Other name(s) : Donepezil hydrochloride || DPZ || Donepezilo || Donepezilum || 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine || (+\/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one || Donepezil || E2020 || Aricept
MW : 415.953
Formula : C24H30ClNO3
CAS_number : 120011-70-3, 120014-06-4
UniChem : XWAIAVWHZJNZQQ-UHFFFAOYSA-N
IUPHAR : 6599
Wikipedia : Donepezil
Target
Families : Aricept~Donepezil~E2020 ligand of proteins in family
ACHE
Structure :
1EVE
7E3H
6O4W
4EY7
Protein :
torca-ACHE
human-ACHE
References (60)
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