| Title : Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401 - Dai_2020_Mar.Drugs_18_ |
| Author(s) : Dai Y , Li K , She J , Zeng Y , Wang H , Liao S , Lin X , Yang B , Wang J , Tao H , Dai H , Zhou X , Liu Y |
| Ref : Mar Drugs , 18 : , 2020 |
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Abstract :
A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo(2) (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC(50) values of 1.3-2.5 M, and an in silico molecular docking study was also performed. |
| PubMedSearch : Dai_2020_Mar.Drugs_18_ |
| PubMedID: 33143384 |
Dai Y, Li K, She J, Zeng Y, Wang H, Liao S, Lin X, Yang B, Wang J, Tao H, Dai H, Zhou X, Liu Y (2020)
Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401
Mar Drugs
18 :
Dai Y, Li K, She J, Zeng Y, Wang H, Liao S, Lin X, Yang B, Wang J, Tao H, Dai H, Zhou X, Liu Y (2020)
Mar Drugs
18 :