| Title : Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice - Damaj_2004_Brain.Res_1024_146 |
| Author(s) : Damaj MI , Hunter RG , Martin BR , Kuhar MJ |
| Ref : Brain Research , 1024 :146 , 2004 |
|
Abstract :
Cocaine- and amphetamine-regulated transcript (CART) peptides are found in brain and spinal cord areas involved in pain transmission. In the present study, we investigated the role of rat CART (55-102) in the modulation of an acute pain model after intrathecal administration. The results show that CART (55-102) was without effect on the tail-flick test after i.t. injection in mice. Interestingly, i.t. administration of CART (55-102) significantly enhanced the antinociceptive effect of morphine in the tail-flick test. These results suggest that CART (55-102) potentiates the effects of opioids to inhibit the nociceptive information transmission. |
| PubMedSearch : Damaj_2004_Brain.Res_1024_146 |
| PubMedID: 15451376 |
Damaj MI, Hunter RG, Martin BR, Kuhar MJ (2004)
Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice
Brain Research
1024 :146
Damaj MI, Hunter RG, Martin BR, Kuhar MJ (2004)
Brain Research
1024 :146