| Title : Stereospecific reactivation of human brain and erythrocyte acetylcholinesterase inhibited by 1,2,2-trimethylpropyl methylphosphonofluoridate (soman) - De Jong_1985_Biochim.Biophys.Acta_830_345 |
| Author(s) : De Jong LP , Kossen SP |
| Ref : Biochimica & Biophysica Acta , 830 :345 , 1985 |
|
Abstract :
Human erythrocyte and brain acetylcholinesterase are preferentially inhibited by the P(-)-isomers of C(+/-)P(+/-)-soman. The enzymes inhibited by the P(-)-isomers behave similarly with respect to oxime-induced reactivation and aging. HI-6 is the best reactivator for C(+)P(-)-soman-inhibited acetylcholinesterases. Oxime-induced reactivation of the C(-)P(-)-soman-inhibited acetylcholinesterases is much more difficult to achieve. |
| PubMedSearch : De Jong_1985_Biochim.Biophys.Acta_830_345 |
| PubMedID: 4027255 |
| Inhibitor | Soman |
De Jong LP, Kossen SP (1985)
Stereospecific reactivation of human brain and erythrocyte acetylcholinesterase inhibited by 1,2,2-trimethylpropyl methylphosphonofluoridate (soman)
Biochimica & Biophysica Acta
830 :345
De Jong LP, Kossen SP (1985)
Biochimica & Biophysica Acta
830 :345