Soman
Nerve agent GD
General
Type : Chemical Warfare Agent, Organophosphate, Nerve Agent G-series, Derivative of Soman
Chemical_Nomenclature : 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane
Canonical SMILES : CC(C(C)(C)C)OP(=O)(C)F
InChI : InChI=1S\/C7H16FO2P\/c1-6(7(2,3)4)10-11(5,8)9\/h6H,1-5H3
InChIKey : GRXKLBBBQUKJJZ-UHFFFAOYSA-N
Other name(s) : Pinacolylmethylphosphonofluoridate || Pinacolyloxymethylphosphorylfluoride || Methylphosphonofluoridic acid, 1,2,2-trimethylpropyl ester || GD || ZINC000038494900
MW : 182.19
Formula : C7H16FO2P
CAS_number : 96-64-0
PubChem : 7305
UniChem : GRXKLBBBQUKJJZ-UHFFFAOYSA-N
Wikipedia : Soman
Target
Families : Soman ligand of proteins in family
BCHE
ACHE
PAF-Acetylhydrolase
Carb_B_Chordata
Carboxypeptidase_S10
Structure :
1SOM
6WVO
6WVC
4B0O
4B0P
4AXB
2WFZ
2WG0
2WG1
2WG2
3F97
2HRQ
1P0P
1P0Q
Protein :
torca-ACHE
human-BCHE
human-PLA2G7
human-CES1
human-CTSA
References (85)
| Title : Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6 - McGuire_2021_Chem.Res.Toxicol_34_804 |
| Author(s) : McGuire JR , Bester SM , Guelta MA , Cheung J , Langley C , Winemiller MD , Bae SY , Funk V , Myslinski JM , Pegan SD , Height JJ |
| Ref : Chemical Research in Toxicology , 34 :804 , 2021 |
| Abstract : |
| PubMedSearch : McGuire_2021_Chem.Res.Toxicol_34_804 |
| PubMedID: 33538594 |
| Gene_locus related to this paper: human-ACHE |
| Title : Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents - Jacquet_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Jacquet P , Remy B , Bross RPT , van Grol M , Gaucher F , Chabriere E , De Koning MC , Daude D |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : |
| PubMedSearch : Jacquet_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 34360916 |
| Title : Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A - Bouknight_2020_Biochem.Pharmacol__113980 |
| Author(s) : Bouknight KD , Jurkouich KM , Compton JR , Khavrutskii IV , Guelta MA , Harvey SP , Legler PM |
| Ref : Biochemical Pharmacology , :113980 , 2020 |
| Abstract : |
| PubMedSearch : Bouknight_2020_Biochem.Pharmacol__113980 |
| PubMedID: 32305437 |
| Gene_locus related to this paper: human-CTSA |
| Title : A step toward the reactivation of aged cholinesterases - Crystal structure of ligands binding to aged human butyrylcholinesterase - Wandhammer_2013_Chem.Biol.Interact_203_19 |
| Author(s) : Wandhammer M , De Koning MC , van Grol M , Loiodice M , Saurel L , Noort D , Goeldner M , Nachon F |
| Ref : Chemico-Biological Interactions , 203 :19 , 2013 |
| Abstract : |
| PubMedSearch : Wandhammer_2013_Chem.Biol.Interact_203_19 |
| PubMedID: 22922115 |
| Gene_locus related to this paper: human-BCHE |
| Title : In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species - Herkert_2011_Toxicol.Lett_206_41 |
| Author(s) : Herkert NM , Thiermann H , Worek F |
| Ref : Toxicol Lett , 206 :41 , 2011 |
| Abstract : |
| PubMedSearch : Herkert_2011_Toxicol.Lett_206_41 |
| PubMedID: 21414391 |
| Title : Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime - Sanson_2009_J.Med.Chem_52_7593 |
| Author(s) : Sanson B , Nachon F , Colletier JP , Froment MT , Toker L , Greenblatt HM , Sussman JL , Ashani Y , Masson P , Silman I , Weik M |
| Ref : Journal of Medicinal Chemistry , 52 :7593 , 2009 |
| Abstract : |
| PubMedSearch : Sanson_2009_J.Med.Chem_52_7593 |
| PubMedID: 19642642 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase - Bartling_2007_Toxicology_233_166 |
| Author(s) : Bartling A , Worek F , Szinicz L , Thiermann H |
| Ref : Toxicology , 233 :166 , 2007 |
| Abstract : |
| PubMedSearch : Bartling_2007_Toxicology_233_166 |
| PubMedID: 16904809 |
| Title : Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun - Fleming_2007_Biochemistry_46_5063 |
| Author(s) : Fleming CD , Edwards CC , Kirby SD , Maxwell DM , Potter PM , Cerasoli DM , Redinbo MR |
| Ref : Biochemistry , 46 :5063 , 2007 |
| Abstract : |
| PubMedSearch : Fleming_2007_Biochemistry_46_5063 |
| PubMedID: 17407327 |
| Gene_locus related to this paper: human-CES1 |
| Title : Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products - Nicolet_2003_J.Biol.Chem_278_41141 |
| Author(s) : Nicolet Y , Lockridge O , Masson P , Fontecilla-Camps JC , Nachon F |
| Ref : Journal of Biological Chemistry , 278 :41141 , 2003 |
| Abstract : |
| PubMedSearch : Nicolet_2003_J.Biol.Chem_278_41141 |
| PubMedID: 12869558 |
| Gene_locus related to this paper: human-BCHE |
| Title : Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level - Millard_1999_Biochemistry_38_7032 |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Greenblatt HM , Harel M , Raves ML , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : Biochemistry , 38 :7032 , 1999 |
| Abstract : |
| PubMedSearch : Millard_1999_Biochemistry_38_7032 |
| PubMedID: 10353814 |
| Gene_locus related to this paper: torca-ACHE |
| Title : A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods - Kassa_1999_Toxicology_132_111 |
| Author(s) : Kassa J , Cabal J |
| Ref : Toxicology , 132 :111 , 1999 |
| Abstract : |
| PubMedSearch : Kassa_1999_Toxicology_132_111 |
| PubMedID: 10433374 |
| Title : Inhibition by soman of NMDA-stimulated [3H]norepinephrine release from rat cortical slices, studies of non-cholinergic effect - Tang_1998_Brain.Res_787_123 |
| Author(s) : Tang HW , Cassel G |
| Ref : Brain Research , 787 :123 , 1998 |
| Abstract : |
| PubMedSearch : Tang_1998_Brain.Res_787_123 |
| PubMedID: 9518577 |
| Title : Electrocorticographic changes during generalized convulsive status epilepticus in soman intoxicated rats - Koplovitz_1998_Epilepsy.Res_30_159 |
| Author(s) : Koplovitz I , Skvorak JP |
| Ref : Epilepsy Research , 30 :159 , 1998 |
| Abstract : |
| PubMedSearch : Koplovitz_1998_Epilepsy.Res_30_159 |
| PubMedID: 9600547 |
| Title : A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats - Kassa_1998_Hum.Exp.Toxicol_17_331 |
| Author(s) : Kassa J |
| Ref : Hum Exp Toxicol , 17 :331 , 1998 |
| Abstract : |
| PubMedSearch : Kassa_1998_Hum.Exp.Toxicol_17_331 |
| PubMedID: 9688357 |
| Title : Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase - Allon_1998_Toxicol.Sci_43_121 |
| Author(s) : Allon N , Raveh L , Gilat E , Cohen E , Grunwald J , Ashani Y |
| Ref : Toxicol Sci , 43 :121 , 1998 |
| Abstract : |
| PubMedSearch : Allon_1998_Toxicol.Sci_43_121 |
| PubMedID: 9710953 |
| Title : Inhalation toxicokinetics of soman stereoisomers in the atropinized guinea pig with nose-only exposure to soman vapor - Langenberg_1998_Toxicol.Appl.Pharmacol_151_79 |
| Author(s) : Langenberg JP , Spruit HE , van der Wiel HJ , Trap HC , Helmich RB , Bergers WW , van Helden HP , Benschop HP |
| Ref : Toxicol Appl Pharmacol , 151 :79 , 1998 |
| Abstract : |
| PubMedSearch : Langenberg_1998_Toxicol.Appl.Pharmacol_151_79 |
| PubMedID: 9705889 |
| Title : Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase - Millard_1998_Biochemistry_37_237 |
| Author(s) : Millard CB , Lockridge O , Broomfield CA |
| Ref : Biochemistry , 37 :237 , 1998 |
| Abstract : |
| PubMedSearch : Millard_1998_Biochemistry_37_237 |
| PubMedID: 9425044 |
| Gene_locus related to this paper: human-BCHE |
| Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237 |
| Author(s) : Worek F , Widmann R , Knopff O , Szinicz L |
| Ref : Archives of Toxicology , 72 :237 , 1998 |
| Abstract : |
| PubMedSearch : Worek_1998_Arch.Toxicol_72_237 |
| PubMedID: 9587020 |
| Title : Mapping of cerebral metabolic activation in three models of cholinergic convulsions - Scremin_1998_Brain.Res.Bull_45_167 |
| Author(s) : Scremin OU , Shih TM , Li MG , Jenden DJ |
| Ref : Brain Research Bulletin , 45 :167 , 1998 |
| Abstract : |
| PubMedSearch : Scremin_1998_Brain.Res.Bull_45_167 |
| PubMedID: 9443835 |
| Title : Effects of various drugs including organophosphorus compounds (OPC) and therapeutic compounds against OPC on DRL responding - Bizot_1998_Pharmacol.Biochem.Behav_59_1069 |
| Author(s) : Bizot JC |
| Ref : Pharmacol Biochem Behav , 59 :1069 , 1998 |
| Abstract : |
| PubMedSearch : Bizot_1998_Pharmacol.Biochem.Behav_59_1069 |
| PubMedID: 9586869 |
| Title : Pharmacokinetics and effects of HI 6 in blood and brain of soman-intoxicated rats: a microdialysis study - Cassel_1997_Eur.J.Pharmacol_332_43 |
| Author(s) : Cassel G , Karlsson L , Waara L , Ang KW , Goransson-Nyberg A |
| Ref : European Journal of Pharmacology , 332 :43 , 1997 |
| Abstract : |
| PubMedSearch : Cassel_1997_Eur.J.Pharmacol_332_43 |
| PubMedID: 9298924 |
| Title : [Acute poisoning by neuroparalytic agents and its long-term effects] - Ianno_1997_Med.Tr.Prom.Ekol_6_5 |
| Author(s) : Ianno LV , Musiichuk Iu I |
| Ref : Med Tr Prom Ekol , 6 :5 , 1997 |
| Abstract : |
| PubMedSearch : Ianno_1997_Med.Tr.Prom.Ekol_6_5 |
| PubMedID: 9273141 |
| Title : Differential inhibition of the brain acetylcholinesterase molecular forms following sarin, soman and VX intoxication in laboratory rats - Bajgar_1997_Acta.Medica_40_89 |
| Author(s) : Bajgar J |
| Ref : Acta Medica , 40 :89 , 1997 |
| Abstract : |
| PubMedSearch : Bajgar_1997_Acta.Medica_40_89 |
| PubMedID: 9481881 |
| Title : [The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice] - Kassa_1997_Cas.Lek.Cesk_136_124 |
| Author(s) : Kassa J , Vachek J |
| Ref : Casopis Lekaru Ceskych , 136 :124 , 1997 |
| Abstract : |
| PubMedSearch : Kassa_1997_Cas.Lek.Cesk_136_124 |
| PubMedID: 9221183 |
| Title : Unique push-pull mechanism of dealkylation in soman-inhibited cholinesterases - Viragh_1997_Biochemistry_36_8243 |
| Author(s) : Viragh C , Akhmetshin R , Kovach IM , Broomfield CA |
| Ref : Biochemistry , 36 :8243 , 1997 |
| Abstract : |
| PubMedSearch : Viragh_1997_Biochemistry_36_8243 |
| PubMedID: 9204869 |
| Title : Correlation between cortical EEG and striatal microdialysis in soman- intoxicated rats - Jacobsson_1997_Neurosci.Lett_231_155 |
| Author(s) : Jacobsson SO , Sellstrom A , Persson SA , Cassel GE |
| Ref : Neuroscience Letters , 231 :155 , 1997 |
| Abstract : |
| PubMedSearch : Jacobsson_1997_Neurosci.Lett_231_155 |
| PubMedID: 9300645 |
| Title : Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning - Saxena_1997_Biochem.Pharmacol_54_269 |
| Author(s) : Saxena A , Maxwell DM , Quinn DM , Radic Z , Taylor P , Doctor BP |
| Ref : Biochemical Pharmacology , 54 :269 , 1997 |
| Abstract : |
| PubMedSearch : Saxena_1997_Biochem.Pharmacol_54_269 |
| PubMedID: 9271331 |
| Title : Prophylactic transdermal treatment with physostigmine and scopolamine against soman intoxication in guinea-pigs - Meshulam_1995_J.Appl.Toxicol_15_263 |
| Author(s) : Meshulam Y , Davidovici R , Wengier A , Levy A |
| Ref : Journal of Applied Toxicology , 15 :263 , 1995 |
| Abstract : |
| PubMedSearch : Meshulam_1995_J.Appl.Toxicol_15_263 |
| PubMedID: 7594194 |
| Title : [Comparison of the effect of selected cholinesterase reactivators combined with atropine on soman and fosdrin toxicity in mice] - Kassa_1995_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove.Suppl_38_63 |
| Author(s) : Kassa J |
| Ref : Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl , 38 :63 , 1995 |
| Abstract : |
| PubMedSearch : Kassa_1995_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove.Suppl_38_63 |
| PubMedID: 9441373 |
| Title : Substrate dependence of amiloride- and soman-induced conformation changes of butyrylcholinesterase as evidenced by high-pressure perturbation - Clery_1995_Biochim.Biophys.Acta_1250_19 |
| Author(s) : Clery C , Heiber-Langer I , Channac L , David L , Balny C , Masson P |
| Ref : Biochimica & Biophysica Acta , 1250 :19 , 1995 |
| Abstract : |
| PubMedSearch : Clery_1995_Biochim.Biophys.Acta_1250_19 |
| PubMedID: 7612649 |
| Title : Origins and diversity of the aging reaction in phosphonate adducts of serine hydrolase enzymes: what characteristics of the active site do they probe? - Bencsura_1995_Biochemistry_34_8989 |
| Author(s) : Bencsura A , Enyedy IJ , Kovach IM |
| Ref : Biochemistry , 34 :8989 , 1995 |
| Abstract : |
| PubMedSearch : Bencsura_1995_Biochemistry_34_8989 |
| PubMedID: 7619798 |
| Title : Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats - Kassa_1995_Toxicology_101_167 |
| Author(s) : Kassa J |
| Ref : Toxicology , 101 :167 , 1995 |
| Abstract : |
| PubMedSearch : Kassa_1995_Toxicology_101_167 |
| PubMedID: 7676463 |
| Title : Phosphotriesterase--a promising candidate for use in detoxification of organophosphates - Tuovinen_1994_Fundam.Appl.Toxicol_23_578 |
| Author(s) : Tuovinen K , Kaliste-Korhonen E , Raushel FM , Hanninen O |
| Ref : Fundamental & Applied Toxicology , 23 :578 , 1994 |
| Abstract : |
| PubMedSearch : Tuovinen_1994_Fundam.Appl.Toxicol_23_578 |
| PubMedID: 7867909 |
| Title : Continuous administration of low dose rates of physostigmine and hyoscine to guinea-pigs prevents the toxicity and reduces the incapacitation produced by soman poisoning - Wetherell_1994_J.Pharm.Pharmacol_46_1023 |
| Author(s) : Wetherell JR |
| Ref : J Pharm Pharmacol , 46 :1023 , 1994 |
| Abstract : |
| PubMedSearch : Wetherell_1994_J.Pharm.Pharmacol_46_1023 |
| PubMedID: 7714714 |
| Title : Toxicokinetics of soman stereoisomers after subcutaneous administration to atropinized guinea pigs - Due_1994_Arch.Toxicol_68_60 |
| Author(s) : Due AH , Trap HC , Langenberg JP , Benschop HP |
| Ref : Archives of Toxicology , 68 :60 , 1994 |
| Abstract : |
| PubMedSearch : Due_1994_Arch.Toxicol_68_60 |
| PubMedID: 8166606 |
| Title : Primate performance decrements following acute soman exposure: failure of chemical countermeasures - Blick_1994_Pharmacol.Biochem.Behav_49_503 |
| Author(s) : Blick DW , Murphy MR , Brown GC , Hartgraves SL |
| Ref : Pharmacology, Biochemistry & Behavior , 49 :503 , 1994 |
| Abstract : |
| PubMedSearch : Blick_1994_Pharmacol.Biochem.Behav_49_503 |
| PubMedID: 7862701 |
| Title : [Decontamination with clay or alcoholate of pigs percutaneously poisoned with VX and soman] - Knezevic_1994_Vojnosanit.Pregl_51_488 |
| Author(s) : Knezevic DL , Tadic V |
| Ref : Vojnosanit Pregl , 51 :488 , 1994 |
| Abstract : |
| PubMedSearch : Knezevic_1994_Vojnosanit.Pregl_51_488 |
| PubMedID: 8585153 |
| Title : The role of nitric oxide in the neuropathology in soman intoxication - Bouchaud_1994_Brain.Res_660_249 |
| Author(s) : Bouchaud C , Chollat-Namy A , Duserre S , Delamanche IS |
| Ref : Brain Research , 660 :249 , 1994 |
| Abstract : |
| PubMedSearch : Bouchaud_1994_Brain.Res_660_249 |
| PubMedID: 7529650 |
| Title : In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human - Clement_1994_Arch.Toxicol_68_648 |
| Author(s) : Clement JG , Erhardt N |
| Ref : Archives of Toxicology , 68 :648 , 1994 |
| Abstract : |
| PubMedSearch : Clement_1994_Arch.Toxicol_68_648 |
| PubMedID: 7857205 |
| Title : Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies - Gentry_1993_Chem.Biol.Interact_87_227 |
| Author(s) : Gentry MK , Saxena A , Ashani Y , Doctor BP |
| Ref : Chemico-Biological Interactions , 87 :227 , 1993 |
| Abstract : |
| PubMedSearch : Gentry_1993_Chem.Biol.Interact_87_227 |
| PubMedID: 7688272 |
| Title : Action of nerve agents to cholinesterases - Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_63 |
| Author(s) : Bajgar J |
| Ref : Sbornik Vedeckych Praci Lekarske Fakulty Karlovy Univerzity , 36 :63 , 1993 |
| Abstract : |
| PubMedSearch : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_63 |
| PubMedID: 8165432 |
| Title : Long-term effects of the anticholinesterases sarin and soman on latencies of muscle action potentials in mouse diaphragm muscle - Smith_1993_J.Pharm.Pharmacol_45_176 |
| Author(s) : Smith AP |
| Ref : J Pharm Pharmacol , 45 :176 , 1993 |
| Abstract : |
| PubMedSearch : Smith_1993_J.Pharm.Pharmacol_45_176 |
| PubMedID: 8097774 |
| Title : Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in rats - Shih_1993_Arch.Toxicol_67_637 |
| Author(s) : Shih TM |
| Ref : Archives of Toxicology , 67 :637 , 1993 |
| Abstract : |
| PubMedSearch : Shih_1993_Arch.Toxicol_67_637 |
| PubMedID: 8311691 |
| Title : Changes of rat blood and tissue cholinesterases following administration of tacrine derivatives in vivo - Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_73 |
| Author(s) : Bajgar J , Skopec F |
| Ref : Sbornik Vedeckych Praci Lekarske Fakulty Karlovy Univerzity , 36 :73 , 1993 |
| Abstract : |
| PubMedSearch : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_73 |
| PubMedID: 8165433 |
| Title : Therapeutic efficacy of bis-pyridinium oximes against diisopropyl fluorophosphate (DFP) and soman intoxication in rodents - |
| Author(s) : Dube SN , Kumar D , Sikder AK , Sikder N , Jaiswal DK , Das Gupta S |
| Ref : Pharmazie , 47 :68 , 1992 |
| PubMedID: 1608992 |
| Title : Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX - Gupta_1992_Neurotoxicol_13_649 |
| Author(s) : Gupta RC , Dettbarn WD |
| Ref : Neurotoxicology , 13 :649 , 1992 |
| Abstract : |
| PubMedSearch : Gupta_1992_Neurotoxicol_13_649 |
| PubMedID: 1475066 |
| Title : Successful pretreatment\/therapy of soman, sarin and VX intoxication - Lennox_1992_Drug.Chem.Toxicol_15_271 |
| Author(s) : Lennox WJ , Harris LW , Anderson DR , Solana RP , Murrow ML , Wade JV |
| Ref : Drug & Chemical Toxicology , 15 :271 , 1992 |
| Abstract : |
| PubMedSearch : Lennox_1992_Drug.Chem.Toxicol_15_271 |
| PubMedID: 1459040 |
| Title : The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats - Anderson_1992_Drug.Chem.Toxicol_15_285 |
| Author(s) : Anderson DR , Harris LW , Woodard CL , Lennox WJ |
| Ref : Drug & Chemical Toxicology , 15 :285 , 1992 |
| Abstract : |
| PubMedSearch : Anderson_1992_Drug.Chem.Toxicol_15_285 |
| PubMedID: 1459041 |
| Title : The influence of inhibitors and other factors on cholinesterases - Bajgar_1991_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_34_5 |
| Author(s) : Bajgar J |
| Ref : Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove , 34 :5 , 1991 |
| Abstract : |
| PubMedSearch : Bajgar_1991_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_34_5 |
| PubMedID: 1759111 |
| Title : Protection from lethality and behavioral incapacitation resulting from intoxication by soman (pinacolyl methylphosphonofluoridate) and treatment with atropine sulfate and 2-PAM chloride in the guinea pig, cavia porcellus - Romano_1991_Drug.Chem.Toxicol_14_21 |
| Author(s) : Romano JA, Jr. , Terry MR , Murrow ML , Mays MZ |
| Ref : Drug & Chemical Toxicology , 14 :21 , 1991 |
| Abstract : |
| PubMedSearch : Romano_1991_Drug.Chem.Toxicol_14_21 |
| PubMedID: 1889376 |
| Title : Phosphylation kinetic constants and oxime-induced reactivation in acetylcholinesterase from fetal bovine serum, bovine caudate nucleus, and electric eel - Hanke_1991_J.Toxicol.Env.Health_34_141 |
| Author(s) : Hanke DW , Overton MA |
| Ref : Journal of Toxicology & Environmental Health , 34 :141 , 1991 |
| Abstract : |
| PubMedSearch : Hanke_1991_J.Toxicol.Env.Health_34_141 |
| PubMedID: 1890690 |
| Title : The effects of soman poisoning in combination with hypovolemic shock - Bottoms_1991_Fundam.Appl.Toxicol_16_622 |
| Author(s) : Bottoms GD , Fessler JF , Pfeifer CA , Johnson M , Roesel OF , Voorhees WD |
| Ref : Fundamental & Applied Toxicology , 16 :622 , 1991 |
| Abstract : |
| PubMedSearch : Bottoms_1991_Fundam.Appl.Toxicol_16_622 |
| PubMedID: 1884907 |
| Title : The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog - Heppner_1991_Neuropharmacol_30_843 |
| Author(s) : Heppner TJ , Fiekers JF |
| Ref : Neuropharmacology , 30 :843 , 1991 |
| Abstract : |
| PubMedSearch : Heppner_1991_Neuropharmacol_30_843 |
| PubMedID: 1664071 |
| Title : Hypothermia: limited tolerance to repeated soman administration and cross-tolerance to oxotremorine - Clement_1991_Pharmacol.Biochem.Behav_39_305 |
| Author(s) : Clement JG |
| Ref : Pharmacol Biochem Behav , 39 :305 , 1991 |
| Abstract : |
| PubMedSearch : Clement_1991_Pharmacol.Biochem.Behav_39_305 |
| PubMedID: 1946573 |
| Title : Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication - Harris_1991_Drug.Chem.Toxicol_14_265 |
| Author(s) : Harris LW , Talbot BG , Lennox WJ , Anderson DR , Solana RP |
| Ref : Drug & Chemical Toxicology , 14 :265 , 1991 |
| Abstract : |
| PubMedSearch : Harris_1991_Drug.Chem.Toxicol_14_265 |
| PubMedID: 1935706 |
| Title : Enzymes as pretreatment drugs for organophosphate toxicity - Doctor_1991_Neurosci.Biobehav.Rev_15_123 |
| Author(s) : Doctor BP , Raveh L , Wolfe AD , Maxwell DM , Ashani Y |
| Ref : Neurosci Biobehav Rev , 15 :123 , 1991 |
| Abstract : |
| PubMedSearch : Doctor_1991_Neurosci.Biobehav.Rev_15_123 |
| PubMedID: 2052184 |
| Title : Neurotransmitter changes in guinea-pig brain regions following soman intoxication - Fosbraey_1990_J.Neurochem_54_72 |
| Author(s) : Fosbraey P , Wetherell JR , French MC |
| Ref : Journal of Neurochemistry , 54 :72 , 1990 |
| Abstract : |
| PubMedSearch : Fosbraey_1990_J.Neurochem_54_72 |
| PubMedID: 1967146 |
| Title : A contribution to the mechanism of action of SAD-128 - Stalc_1990_Biochem.Pharmacol_40_2511 |
| Author(s) : Stalc A , Sentjurc M |
| Ref : Biochemical Pharmacology , 40 :2511 , 1990 |
| Abstract : |
| PubMedSearch : Stalc_1990_Biochem.Pharmacol_40_2511 |
| PubMedID: 2176500 |
| Title : A new H-oxime restores rat diaphragm contractility after esterase inhibition in vitro - Alberts_1990_Eur.J.Pharmacol_184_191 |
| Author(s) : Alberts P |
| Ref : European Journal of Pharmacology , 184 :191 , 1990 |
| Abstract : |
| PubMedSearch : Alberts_1990_Eur.J.Pharmacol_184_191 |
| PubMedID: 2209712 |
| Title : Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases - Silveira_1990_Toxicol.Appl.Pharmacol_103_474 |
| Author(s) : Silveira CL , Eldefrawi AT , Eldefrawi ME |
| Ref : Toxicol Appl Pharmacol , 103 :474 , 1990 |
| Abstract : |
| PubMedSearch : Silveira_1990_Toxicol.Appl.Pharmacol_103_474 |
| PubMedID: 2339420 |
| Title : Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning - Garrigue_1990_Xenobiotica_20_699 |
| Author(s) : Garrigue H , Maurizis JC , Nicolas C , Madelmont JC , Godeneche D , Hulot T , Morge X , Demerseman P , Sentenac-Roumanou H , Veyre A |
| Ref : Xenobiotica , 20 :699 , 1990 |
| Abstract : |
| PubMedSearch : Garrigue_1990_Xenobiotica_20_699 |
| PubMedID: 2146816 |
| Title : Detection of the organophosphorus nerve agent soman by an ELISA using monoclonal antibodies - Erhard_1990_Arch.Toxicol_64_580 |
| Author(s) : Erhard MH , Kuhlmann R , Szinicz L , Losch U |
| Ref : Archives of Toxicology , 64 :580 , 1990 |
| Abstract : |
| PubMedSearch : Erhard_1990_Arch.Toxicol_64_580 |
| PubMedID: 2073131 |
| Title : A microassay-based procedure for measuring low levels of toxic organophosphorus compounds through acetylcholinesterase inhibition - Hammond_1989_Anal.Biochem_180_380 |
| Author(s) : Hammond PS , Forster JS |
| Ref : Analytical Biochemistry , 180 :380 , 1989 |
| Abstract : |
| PubMedSearch : Hammond_1989_Anal.Biochem_180_380 |
| PubMedID: 2817369 |
| Title : Effects of soman and its antidotes on tracheal mucociliary transport of ferrets - Marin_1989_J.App.Physio_66_1390 |
| Author(s) : Marin MG , Zwierzynski D , McBride RK , Culp DJ |
| Ref : Journal of Applied Physiology , 66 :1390 , 1989 |
| Abstract : |
| PubMedSearch : Marin_1989_J.App.Physio_66_1390 |
| PubMedID: 2496095 |
| Title : Comparison of the effects of diisopropylfluorophosphate, sarin, soman, and tabun on toxicity and brain acetylcholinesterase activity in mice - Tripathi_1989_J.Toxicol.Environ.Health_26_437 |
| Author(s) : Tripathi HL , Dewey WL |
| Ref : J Toxicol Environ Health , 26 :437 , 1989 |
| Abstract : |
| PubMedSearch : Tripathi_1989_J.Toxicol.Environ.Health_26_437 |
| PubMedID: 2709438 |
| Title : Acute and sub-acute inhalation of an organophosphate induce alteration of cholinergic muscarinic receptors - Aas_1987_Biochem.Pharmacol_36_1261 |
| Author(s) : Aas P , Veiteberg TA , Fonnum F |
| Ref : Biochemical Pharmacology , 36 :1261 , 1987 |
| Abstract : |
| PubMedSearch : Aas_1987_Biochem.Pharmacol_36_1261 |
| PubMedID: 3593413 |
| Title : Interaction of soman with beta-cyclodextrin - Desire_1986_Fundam.Appl.Toxicol_7_646 |
| Author(s) : Desire B , Saint-Andre S |
| Ref : Fundamental & Applied Toxicology , 7 :646 , 1986 |
| Abstract : |
| PubMedSearch : Desire_1986_Fundam.Appl.Toxicol_7_646 |
| PubMedID: 3803759 |
| Title : Clonidine protection from soman and echothiophate toxicity in mice - Aronstam_1986_Life.Sci_39_2097 |
| Author(s) : Aronstam RS , Smith MD , Buccafusco JJ |
| Ref : Life Sciences , 39 :2097 , 1986 |
| Abstract : |
| PubMedSearch : Aronstam_1986_Life.Sci_39_2097 |
| PubMedID: 3784771 |
| Title : Stereospecific reactivation of human brain and erythrocyte acetylcholinesterase inhibited by 1,2,2-trimethylpropyl methylphosphonofluoridate (soman) - De Jong_1985_Biochim.Biophys.Acta_830_345 |
| Author(s) : De Jong LP , Kossen SP |
| Ref : Biochimica & Biophysica Acta , 830 :345 , 1985 |
| Abstract : |
| PubMedSearch : De Jong_1985_Biochim.Biophys.Acta_830_345 |
| PubMedID: 4027255 |
| Title : Influence of atropine upon ageing and reactivation of soman inhibited acetylcholinesterase from human erythrocytes. Preliminary communication - Kuhnen_1985_Arzneimittelforschung_35_1454 |
| Author(s) : Kuhnen H , Schrichten A , Schoene K |
| Ref : Arzneimittelforschung , 35 :1454 , 1985 |
| Abstract : |
| PubMedSearch : Kuhnen_1985_Arzneimittelforschung_35_1454 |
| PubMedID: 4084346 |
| Title : Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites - Martin_1985_J.Neurol.Sci_71_1 |
| Author(s) : Martin LJ , Doebler JA , Anthony A |
| Ref : Journal of the Neurological Sciences , 71 :1 , 1985 |
| Abstract : |
| PubMedSearch : Martin_1985_J.Neurol.Sci_71_1 |
| PubMedID: 2418157 |
| Title : Neurobehavioral effects of repeated sublethal soman in primates - Gause_1985_Pharmacol.Biochem.Behav_23_1003 |
| Author(s) : Gause EM , Hartmann RJ , Leal BZ , Geller I |
| Ref : Pharmacol Biochem Behav , 23 :1003 , 1985 |
| Abstract : |
| PubMedSearch : Gause_1985_Pharmacol.Biochem.Behav_23_1003 |
| PubMedID: 4080770 |
| Title : Treatment of poisoning by soman - Leadbeater_1985_Fundam.Appl.Toxicol_5_S225 |
| Author(s) : Leadbeater L , Inns RH , Rylands JM |
| Ref : Fundamental & Applied Toxicology , 5 :S225 , 1985 |
| Abstract : |
| PubMedSearch : Leadbeater_1985_Fundam.Appl.Toxicol_5_S225 |
| PubMedID: 4092890 |
| Title : Studies on low dose sub-acute administration of soman, sarin and tabun in the rat - Dulaney_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_234 |
| Author(s) : Dulaney MD, Jr. , Hoskins B , Ho IK |
| Ref : Acta Pharmacologica et Toxicologica (Copenh) , 57 :234 , 1985 |
| Abstract : |
| PubMedSearch : Dulaney_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_234 |
| PubMedID: 4083033 |
| Title : Isolation, anticholinesterase properties, and acute toxicity in mice of the four stereoisomers of the nerve agent soman - Benschop_1984_Toxicol.Appl.Pharmacol_72_61 |
| Author(s) : Benschop HP , Konings CA , Van Genderen J , De Jong LP |
| Ref : Toxicology & Applied Pharmacology , 72 :61 , 1984 |
| Abstract : |
| PubMedSearch : Benschop_1984_Toxicol.Appl.Pharmacol_72_61 |
| PubMedID: 6710485 |
| Title : PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning - Boskovic_1984_Fundam.Appl.Toxicol_4_S106 |
| Author(s) : Boskovic B , Kovacevic V , Jovanovic D |
| Ref : Fundamental & Applied Toxicology , 4 :S106 , 1984 |
| Abstract : |
| PubMedSearch : Boskovic_1984_Fundam.Appl.Toxicol_4_S106 |
| PubMedID: 6724203 |
| Title : Delayed neuropathy by the organophosphorus nerve agents soman and tabun - Willems_1984_Arch.Toxicol_55_76 |
| Author(s) : Willems JL , Nicaise M , De Bisschop HC |
| Ref : Archives of Toxicology , 55 :76 , 1984 |
| Abstract : |
| PubMedSearch : Willems_1984_Arch.Toxicol_55_76 |
| PubMedID: 6329137 |
| Title : Brain neuronal RNA metabolism during acute soman toxication: effects of antidotal pretreatments - Doebler_1983_Neurochem.Res_8_997 |
| Author(s) : Doebler JA , Bocan TM , Moore RA , Shih TM , Anthony A |
| Ref : Neurochemical Research , 8 :997 , 1983 |
| Abstract : |
| PubMedSearch : Doebler_1983_Neurochem.Res_8_997 |
| PubMedID: 6194444 |
| Title : Persistence of the anti-cholinesterase soman in rats\; antagonism with a non-toxic simulator of this organophosphate - Wolthuis_1981_Eur.J.Pharmacol_69_379 |
| Author(s) : Wolthuis OL , Benschop HP , Berends F |
| Ref : European Journal of Pharmacology , 69 :379 , 1981 |
| Abstract : |
| PubMedSearch : Wolthuis_1981_Eur.J.Pharmacol_69_379 |
| PubMedID: 7215436 |
| Title : Protection and induced reactivation of cholinesterase by HS-6 in rabbits exposed to soman - |
| Author(s) : Harris LW , Stitcher DL , Heyl WC |
| Ref : Life Sciences , 29 :1747 , 1981 |
| PubMedID: 7300570 |
| Title : Reactivation of acetylcholinesterase inhibited by 1,2,2'-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes - |
| Author(s) : De Jong LP , Wolring GZ |
| Ref : Biochemical Pharmacology , 29 :2379 , 1980 |
| PubMedID: 7426043 |
| Title : Phosphorylation of acetylcholinesterase in bovine blood by Paraoxon and Soman - Nenner_1973_Arch.Toxikol_30_87 |
| Author(s) : Nenner M |
| Ref : Arch Toxikol , 30 :87 , 1973 |
| Abstract : |
| PubMedSearch : Nenner_1973_Arch.Toxikol_30_87 |
| PubMedID: 4685268 |
| Title : Failure of toxogonin to reactivate soman-inhibited brain acetylcholinesterase in monkeys and regeneration of the enzyme - |
| Author(s) : Filbert MG , Fleisher JH , Lochner MA |
| Ref : Biochimica & Biophysica Acta , 284 :164 , 1972 |
| PubMedID: 4627450 |