Title : Dipeptidyl peptidase 4 inhibition with sitagliptin: a new therapy for type 2 diabetes - Deacon_2007_Expert.Opin.Investig.Drugs_16_533 |
Author(s) : Deacon CF |
Ref : Expert Opin Investig Drugs , 16 :533 , 2007 |
Abstract :
Sitagliptin is a once-daily, orally active, competitive and fully reversible inhibitor of dipeptidyl peptidase 4, the enzyme that is responsible for the rapid degradation of the incretin hormone glucagon-like peptide-1. It is the first in this new class of antihyperglycaemic agents to gain regulatory approval for the treatment of Type 2 diabetes, both as a monotherapy and for use in combination with metformin or a thiazolidinedione. In clinical trials of < or = 1-year duration, sitagliptin improves glycaemic control by reducing both fasting and postprandial glucose concentrations, leading to clinically meaningful reductions in glycosylated haemoglobin levels. It is safe and well tolerated, with a side-effect profile that is similar to that of the placebo, a low incidence of hypoglycaemia and body weight neutrality. Further clinical experience with sitagliptin will reveal its long-term durability, safety and efficacy. |
PubMedSearch : Deacon_2007_Expert.Opin.Investig.Drugs_16_533 |
PubMedID: 17371200 |
Inhibitor | Sitagliptin |
Deacon CF (2007)
Dipeptidyl peptidase 4 inhibition with sitagliptin: a new therapy for type 2 diabetes
Expert Opin Investig Drugs
16 :533
Deacon CF (2007)
Expert Opin Investig Drugs
16 :533