Della Pietra_2022_Int.J.Mol.Sci_23_

Reference

Title : Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain - Della Pietra_2022_Int.J.Mol.Sci_23_
Author(s) : Della Pietra A , Savinainen J , Giniatullin R
Ref : Int J Mol Sci , 23 : , 2022
Abstract :

Migraine is a disabling neurovascular disorder characterized by severe pain with still limited efficient treatments. Endocannabinoids, the endogenous painkillers, emerged, alternative to plant cannabis, as promising analgesics against migraine pain. In this thematic review, we discuss how inhibition of the main endocannabinoid-degrading enzymes, monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), could raise the level of endocannabinoids (endoCBs) such as 2-AG and anandamide in order to alleviate migraine pain. We describe here: (i) migraine pain signaling pathways, which could serve as specific targets for antinociception; (ii) a divergent distribution of MAGL and FAAH activities in the key regions of the PNS and CNS implicated in migraine pain signaling; (iii) a complexity of anti-nociceptive effects of endoCBs mediated by cannabinoid receptors and through a direct modulation of ion channels in nociceptive neurons; and (iv) the spectrum of emerging potent MAGL and FAAH inhibitors which efficiently increase endoCBs levels. The specific distribution and homeostasis of endoCBs in the main regions of the nociceptive system and their generation 'on demand', along with recent availability of MAGL and FAAH inhibitors suggest new perspectives for endoCBs-mediated analgesia in migraine pain.

PubMedSearch : Della Pietra_2022_Int.J.Mol.Sci_23_
PubMedID: 35457225
Gene_locus related to this paper: human-MGLL

Related information

Inhibitor AKU-005
Gene_locus AKU-005    human-MGLL

Citations formats

Della Pietra A, Savinainen J, Giniatullin R (2022)
Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain
Int J Mol Sci 23 :

Della Pietra A, Savinainen J, Giniatullin R (2022)
Int J Mol Sci 23 :