Title : The effect of some new aminopyridines on mammalian non-myelinated nerve fibres - Den Hertog_1983_Eur.J.Pharmacol_94_353 |
Author(s) : Den Hertog A , Pielkenrood J , Biessels P , Agoston S |
Ref : European Journal of Pharmacology , 94 :353 , 1983 |
Abstract :
We evaluated the action of 2,4-, 3,4-diaminopyridine and 3-[(dimethylamino)carbonyl]amino,4-aminopyridine (LF-14) on non-myelinated fibres of the guinea-pig vagus nerve. The amplitude and duration of the compound action potential were enhanced similarly by all of the aminopyridines. The propagation velocity of the compound action potential and electrogenic sodium pumping were not changed by the aminopyridines. The results show that 2,4-diAP and LF-14 affect non-myelinated nerve fibres of the guinea-pig in the same way as does 3,4-diAP; sodium pumping was not modified by the aminopyridines. |
PubMedSearch : Den Hertog_1983_Eur.J.Pharmacol_94_353 |
PubMedID: 6653665 |
Inhibitor | LF-14 |
Den Hertog A, Pielkenrood J, Biessels P, Agoston S (1983)
The effect of some new aminopyridines on mammalian non-myelinated nerve fibres
European Journal of Pharmacology
94 :353
Den Hertog A, Pielkenrood J, Biessels P, Agoston S (1983)
European Journal of Pharmacology
94 :353