LF-14
A 3,4-diaminopyridine derivative both promotes ACh release and inhibits its breakdown by AChE
General
Type : Pyridine, Urea derivative
Chemical_Nomenclature : 3-(4-aminopyridin-3-yl)-1,1-dimethylurea
Canonical SMILES : CN(C)C(=O)NC1=C(C=CN=C1)N
InChI : InChI=1S\/C8H12N4O\/c1-12(2)8(13)11-7-5-10-4-3-6(7)9\/h3-5H,1-2H3,(H2,9,10)(H,11,13)
InChIKey : ZGDYCZUBOHHZEE-UHFFFAOYSA-N
Other name(s) : LF 14 || 3-((Dimethylamino)carbonyl)amino-4-aminopyridine.gif || SCHEMBL7653834
MW : 180.21
Formula : C8H12N4O
CAS_number : 88404-01-7
PubChem : 145881
UniChem : ZGDYCZUBOHHZEE-UHFFFAOYSA-N
Target
Families : LF-14 ligand of proteins in family
ACHE
References (6)
| Title : Effects of LF-14, THA and physostigmine in rat hippocampus and cerebral cortex - Potter_1989_Neurochem.Int_14_433 |
| Author(s) : Potter PE , Nitta S , Chaudhry I , Lalezari I , Goldiner P , Foldes FF |
| Ref : Neurochem Int , 14 :433 , 1989 |
| Abstract : |
| PubMedSearch : Potter_1989_Neurochem.Int_14_433 |
| PubMedID: 20504446 |
| Title : The influence of aminopyridines on Ca2+-dependent evoked release of acetylcholine from rat cortex slices - Foldes_1988_Neurochem.Res_13_761 |
| Author(s) : Foldes FF , Ludvig N , Nagashima H , Vizi ES |
| Ref : Neurochem Res , 13 :761 , 1988 |
| Abstract : |
| PubMedSearch : Foldes_1988_Neurochem.Res_13_761 |
| PubMedID: 2845287 |
| Title : Effect of mono- and diaminopyridines on release of [3H]norepinephrine from isolated guinea-pig atrium - Sugimori_1987_Neuropharmacol_26_621 |
| Author(s) : Sugimori T , Nagashima H , Vizi ES , Harsing LG, Jr. , Chaudhry I , Lalezari I , Duncalf D , Goldiner PL , Foldes FF |
| Ref : Neuropharmacology , 26 :621 , 1987 |
| Abstract : |
| PubMedSearch : Sugimori_1987_Neuropharmacol_26_621 |
| PubMedID: 3037424 |
| Title : A comparison of the pharmacological actions of 4-aminopyridine and two of its derivatives in the monkey - Biessels_1987_Eur.J.Pharmacol_135_155 |
| Author(s) : Biessels PT , Houwertjes MC , Agoston S , Horn AS |
| Ref : European Journal of Pharmacology , 135 :155 , 1987 |
| Abstract : |
| PubMedSearch : Biessels_1987_Eur.J.Pharmacol_135_155 |
| PubMedID: 3034626 |
| Title : Comparison of the pharmacological actions of some new 4-aminopyridine derivatives - Biessels_1984_Eur.J.Pharmacol_106_319 |
| Author(s) : Biessels PT , Agoston S , Horn AS |
| Ref : European Journal of Pharmacology , 106 :319 , 1984 |
| Abstract : |
| PubMedSearch : Biessels_1984_Eur.J.Pharmacol_106_319 |
| PubMedID: 6529978 |
| Title : The effect of some new aminopyridines on mammalian non-myelinated nerve fibres - Den Hertog_1983_Eur.J.Pharmacol_94_353 |
| Author(s) : Den Hertog A , Pielkenrood J , Biessels P , Agoston S |
| Ref : European Journal of Pharmacology , 94 :353 , 1983 |
| Abstract : |
| PubMedSearch : Den Hertog_1983_Eur.J.Pharmacol_94_353 |
| PubMedID: 6653665 |