| Title : 3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors - Dogruer_2004_Bioorg.Med.Chem.Lett_14_523 |
| Author(s) : Dogruer D , Lee M , Dukat M , Damaj MI , Martin BR , Glennon RA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :523 , 2004 |
|
Abstract :
The binding of a series pyridylbutynylamines 6 was examined at alpha4beta2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models. |
| PubMedSearch : Dogruer_2004_Bioorg.Med.Chem.Lett_14_523 |
| PubMedID: 14698195 |
Dogruer D, Lee M, Dukat M, Damaj MI, Martin BR, Glennon RA (2004)
3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors
Bioorganic & Medicinal Chemistry Lett
14 :523
Dogruer D, Lee M, Dukat M, Damaj MI, Martin BR, Glennon RA (2004)
Bioorganic & Medicinal Chemistry Lett
14 :523