| Title : Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi - Dong_2016_Org.Lett_18_4498 |
| Author(s) : Dong LB , Wu XD , Shi X , Zhang ZJ , Yang J , Zhao QS |
| Ref : Org Lett , 18 :4498 , 2016 |
|
Abstract :
Five new Lycopodium alkaloids, phleghenrines A-D (1-4) and neophleghenrine A (5), were isolated from Phlegmariurus henryi (Baker) Ching. The structures and absolute configurations of 1-5 were determined using extensive spectroscopic data coupled with computational calculations and revealed 1-4 possess a bicyclo[3.2.2]nonane core, whereas 5 possesses an unprecedented 9-azaprotoadamantane core. Compounds 1 and 4 showed potent acetylcholinesterase (AChE) inhibitory activities, and 4 is a good lead natural product for the treatment of Alzheimer's disease. |
| PubMedSearch : Dong_2016_Org.Lett_18_4498 |
| PubMedID: 27583693 |
Dong LB, Wu XD, Shi X, Zhang ZJ, Yang J, Zhao QS (2016)
Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi
Org Lett
18 :4498
Dong LB, Wu XD, Shi X, Zhang ZJ, Yang J, Zhao QS (2016)
Org Lett
18 :4498