| Title : Chemo-enzymatic Baeyer-Villiger oxidation of 4-methylcyclohexanone via kinetic resolution of racemic carboxylic acids: direct access to enantioenriched lactone - Drozdz_2016_Chem.Commun.(Camb)_52_1230 |
| Author(s) : Drozdz A , Chrobok A |
| Ref : Chem Commun (Camb) , 52 :1230 , 2016 |
|
Abstract :
A new method for the asymmetric chemo-enzymatic Baeyer-Villiger oxidation of prochiral 4-methylcyclohexanone to (R)-4-methylcaprolactone in the presence of (+/-)-4-methyloctanoic acid, Candida Antarctica lipase B and 30% aq. H2O2 has been developed. A mechanism for the asymmetric induction based on kinetic resolution of racemic carboxylic acids is proposed. |
| PubMedSearch : Drozdz_2016_Chem.Commun.(Camb)_52_1230 |
| PubMedID: 26612109 |
| Gene_locus related to this paper: canar-LipB |
| Gene_locus | canar-LipB |
Drozdz A, Chrobok A (2016)
Chemo-enzymatic Baeyer-Villiger oxidation of 4-methylcyclohexanone via kinetic resolution of racemic carboxylic acids: direct access to enantioenriched lactone
Chem Commun (Camb)
52 :1230
Drozdz A, Chrobok A (2016)
Chem Commun (Camb)
52 :1230