| Title : Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel - Dudai_1973_Proc.Natl.Acad.Sci.U.S.A_70_2473 |
| Author(s) : Dudai Y , Herzberg M , Silman I |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 70 :2473 , 1973 |
|
Abstract :
Three purified molecular forms of acetylcholinesterase (EC 3.1.1.7) with sedimentation coefficients of 18 S, 14 S, and 11 S were studied by analytical ultracentrifugation and electron microscopy. The three species have molecular weights of (1.1 +/- 0.1) x 10(6), (7.5 +/- 1.5) x 10(5), and (3.35 +/- 0.25) x 10(5), respectively. Electron micrographs reveal that the 18S and 14S forms are asymmetric, composed of a head, containing a large number of subunits, and an elongated tail. The 11S form of acetylcholinesterase is apparently a tetrameric structure devoid of the tail. Maleylation of 18S and 14S acetylcholinesterases abolishes their tendency to aggregate at low ionic strength. |
| PubMedSearch : Dudai_1973_Proc.Natl.Acad.Sci.U.S.A_70_2473 |
| PubMedID: 4517659 |
Dudai Y, Herzberg M, Silman I (1973)
Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel
Proceedings of the National Academy of Sciences of the United States of America
70 :2473
Dudai Y, Herzberg M, Silman I (1973)
Proceedings of the National Academy of Sciences of the United States of America
70 :2473