| Title : (+\/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents - Dukat_2004_Bioorg.Med.Chem.Lett_14_3651 |
| Author(s) : Dukat M , Taroua M , Dahdouh A , Siripurapu U , Damaj MI , Martin BR , Glennon RA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :3651 , 2004 |
|
Abstract :
Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown. |
| PubMedSearch : Dukat_2004_Bioorg.Med.Chem.Lett_14_3651 |
| PubMedID: 15203136 |
Dukat M, Taroua M, Dahdouh A, Siripurapu U, Damaj MI, Martin BR, Glennon RA (2004)
(+\/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents
Bioorganic & Medicinal Chemistry Lett
14 :3651
Dukat M, Taroua M, Dahdouh A, Siripurapu U, Damaj MI, Martin BR, Glennon RA (2004)
Bioorganic & Medicinal Chemistry Lett
14 :3651