Ece_2007_Clin.Biochem_40_634

Reference

Title : Paraoxonase, total antioxidant activity and peroxide levels in marasmic children: relationships with leptin - Ece_2007_Clin.Biochem_40_634
Author(s) : Ece A , Gurkan F , Celik F , Bosnak M , Yel S , Balik H , Erel O
Ref : Clinical Biochemistry , 40 :634 , 2007
Abstract :

OBJECTIVES: The aim of this study was to investigate the oxidant/antioxidant status, paraoxonase (PON) activity and leptin levels in children with marasmic malnutrition. DESIGN AND
METHODS: Thirty marasmic children (age 14.4+/-10.3 months) and 28 control subjects were included. Plasma PON activity, total antioxidant activity (TAO), total peroxide (TPX) and leptin levels were measured.
RESULTS: Malnourished children had significantly lower leptin (3.6+/-1.1 vs. 11.8+/-4.5 ng/mL, P<0.001), PON activity (66.4+/-28.6 vs. 221.3+/-31.6 IU/L, P<0.001) and TAO (1.44+/-0.12 vs. 2.45+/-0.61 mmol Trolox equiv/L, P<0.001); and higher TPX (15.6+/-6.4 vs. 5.9+/-1.9 micromol/L, P<0.001) values than in controls. Significant negative correlation was found between PON and TPX (P=0.040) and positive correlation between TAO and BMI (P=0.034) in patients. No significant correlation was found between leptin and oxidant/antioxidant parameters (P>0.05).
CONCLUSIONS: Children with marasmic malnutrition had increased pro-oxidant and decreased antioxidant status. Extent of oxidative stress increases with malnutrition severity. Antioxidants could be given during nutritional rehabilitation.

PubMedSearch : Ece_2007_Clin.Biochem_40_634
PubMedID: 17433811

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Citations formats

Ece A, Gurkan F, Celik F, Bosnak M, Yel S, Balik H, Erel O (2007)
Paraoxonase, total antioxidant activity and peroxide levels in marasmic children: relationships with leptin
Clinical Biochemistry 40 :634

Ece A, Gurkan F, Celik F, Bosnak M, Yel S, Balik H, Erel O (2007)
Clinical Biochemistry 40 :634