| Title : Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles - Eddahmi_2022_Bioorg.Chem_130_106261 |
| Author(s) : Eddahmi M , La Spada G , Hafid A , Khouili M , Catto M , Bouissane L |
| Ref : Bioorg Chem , 130 :106261 , 2022 |
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Abstract :
In this work, we have investigated the one pot strategy for the Cu(I)-mediated synthesis of new triazoles bearing nitroindazole moieties using different copper catalysts. The biological activity of newly synthesized nitroindazolyltriazoles towards Alzheimer's disease-related targets, namely cholinesterases, monoamine oxidases, and amyloid aggregation, were investigated. Predictions of target affinity, physicochemical parameters, gastrointestinal absorption and brain penetration were achieved by means of in silico tools. |
| PubMedSearch : Eddahmi_2022_Bioorg.Chem_130_106261 |
| PubMedID: 36399866 |
Eddahmi M, La Spada G, Hafid A, Khouili M, Catto M, Bouissane L (2022)
Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles
Bioorg Chem
130 :106261
Eddahmi M, La Spada G, Hafid A, Khouili M, Catto M, Bouissane L (2022)
Bioorg Chem
130 :106261