| Title : Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells - Elgoyhen_1994_Cell_79_705 |
| Author(s) : Elgoyhen AB , Johnson DS , Boulter J , Vetter DE , Heinemann S |
| Ref : Cell , 79 :705 , 1994 |
|
Abstract :
We report the isolation and functional characterization of a member of the nicotinic acetylcholine receptor subunit gene family, alpha 9. Xenopus oocytes injected with alpha 9 cRNA express a homomeric receptor-channel complex that is activated by acetylcholine. The alpha 9 receptor displays an unusual mixed nicotinic-muscarinic pharmacological profile. The unique properties of the alpha 9 receptor-channel complex closely match those described for the cholinergic receptor present in vertebrate cochlear hair cells. In situ hybridization studies reveal a restricted pattern of alpha 9 gene expression that includes the outer hair cells of the rat cochlea. Our results suggest that the alpha 9 receptor is involved in the cholinergic efferent innervation of cochlear hair cells and thus may modulate the encoding of auditory stimuli. |
| PubMedSearch : Elgoyhen_1994_Cell_79_705 |
| PubMedID: 7954834 |
Elgoyhen AB, Johnson DS, Boulter J, Vetter DE, Heinemann S (1994)
Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells
Cell
79 :705
Elgoyhen AB, Johnson DS, Boulter J, Vetter DE, Heinemann S (1994)
Cell
79 :705