| Title : An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients - Enomoto_2014_Gastroenterol.Res.Pract_2014_351396 |
| Author(s) : Enomoto H , Aizawa N , Nakamura H , Sakai Y , Iwata Y , Tanaka H , Ikeda N , Aoki T , Yuri Y , Yoh K , Hashimoto K , Ishii A , Takashima T , Iwata K , Saito M , Imanishi H , Iijima H , Nishiguchi S |
| Ref : Gastroenterol Res Pract , 2014 :351396 , 2014 |
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Abstract :
Background. In hepatitis B virus- (HBV-) positive patients, the relationship between the metabolic variables and histological degree of liver fibrosis has been poorly investigated. Methods. A total of 176 HBV-positive patients were assessed in whom the ratios of glycated albumin-to-glycated hemoglobin (GA/HbA1c) were calculated in order to investigate the relationship with the degree of liver fibrosis. Results. The GA/HbA1c ratio increased in association with the severity of fibrosis (METAVIR scores: F0-1: 2.61 +/- 0.24, F2: 2.65 +/- 0.24, F3: 2.74 +/- 0.38, and F4: 2.91 +/- 0.63). The GA/HbA1c ratios were inversely correlated with four variables of liver function: the prothrombin time (PT) percentage (P < 0.0001), platelet count (P < 0.0001), albumin value (P < 0.0001), and cholinesterase value (P < 0.0001). The GA/HbA1c ratio was positively correlated with two well-known markers of liver fibrosis, FIB-4 (P < 0.0001) and the AST-to-platelet ratio index (APRI) (P < 0.0001). Furthermore, the GA/HbA1c showed better correlations with two variables of liver function (PT percentage and cholinesterase value) than did FIB-4 and with all four variables than did the APRI. Conclusion. The GA/HbA1c ratio is associated with the degree of liver fibrosis in HBV-positive patients. |
| PubMedSearch : Enomoto_2014_Gastroenterol.Res.Pract_2014_351396 |
| PubMedID: 24693282 |
Enomoto H, Aizawa N, Nakamura H, Sakai Y, Iwata Y, Tanaka H, Ikeda N, Aoki T, Yuri Y, Yoh K, Hashimoto K, Ishii A, Takashima T, Iwata K, Saito M, Imanishi H, Iijima H, Nishiguchi S (2014)
An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients
Gastroenterol Res Pract
2014 :351396
Enomoto H, Aizawa N, Nakamura H, Sakai Y, Iwata Y, Tanaka H, Ikeda N, Aoki T, Yuri Y, Yoh K, Hashimoto K, Ishii A, Takashima T, Iwata K, Saito M, Imanishi H, Iijima H, Nishiguchi S (2014)
Gastroenterol Res Pract
2014 :351396