| Title : Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors - Ferretti_2003_Bioorg.Med.Chem.Lett_13_733 |
| Author(s) : Ferretti G , Dukat M , Giannella M , Piergentili A , Pigini M , Quaglia W , Damaj MI , Martin BR , Glennon RA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 13 :733 , 2003 |
|
Abstract :
A total of 20 substituted analogues of nicotine (1a) and homoazanicotine (3a) were examined in order to determine whether or not they might bind in a similar manner at alpha4beta2 nicotinic acetylcholinergic (nACh) receptors. It was found that parallel structural changes in the two series resulted in parallel shifts in affinity. Evidence suggests that the two series are binding in a comparable fashion. |
| PubMedSearch : Ferretti_2003_Bioorg.Med.Chem.Lett_13_733 |
| PubMedID: 12639569 |
Ferretti G, Dukat M, Giannella M, Piergentili A, Pigini M, Quaglia W, Damaj MI, Martin BR, Glennon RA (2003)
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors
Bioorganic & Medicinal Chemistry Lett
13 :733
Ferretti G, Dukat M, Giannella M, Piergentili A, Pigini M, Quaglia W, Damaj MI, Martin BR, Glennon RA (2003)
Bioorganic & Medicinal Chemistry Lett
13 :733