| Title : Retrospective detection of exposure to organophosphorus anti-cholinesterases: mass spectrometric analysis of phosphylated human butyrylcholinesterase - Fidder_2002_Chem.Res.Toxicol_15_582 |
| Author(s) : Fidder A , Hulst AG , Noort D , de Ruiter R , van der Schans MJ , Benschop HP , Langenberg JP |
| Ref : Chemical Research in Toxicology , 15 :582 , 2002 |
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Abstract :
In this paper a novel and general procedure is presented for detection of organophosphate-inhibited human butyrylcholinesterase (HuBuChE), which is based on electrospray tandem mass spectrometric analysis of phosphylated nonapeptides obtained after pepsin digestion of the enzyme. The utility of this method is exemplified by the positive analysis of serum samples from Japanese victims of the terrorist attack with sarin in the Tokyo subway in 1995. |
| PubMedSearch : Fidder_2002_Chem.Res.Toxicol_15_582 |
| PubMedID: 11952345 |
Fidder A, Hulst AG, Noort D, de Ruiter R, van der Schans MJ, Benschop HP, Langenberg JP (2002)
Retrospective detection of exposure to organophosphorus anti-cholinesterases: mass spectrometric analysis of phosphylated human butyrylcholinesterase
Chemical Research in Toxicology
15 :582
Fidder A, Hulst AG, Noort D, de Ruiter R, van der Schans MJ, Benschop HP, Langenberg JP (2002)
Chemical Research in Toxicology
15 :582