| Title : Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays - Figueiredo-Gonzalez_2018_Food.Res.Int_106_558 |
| Author(s) : Figueiredo-Gonzalez M , Reboredo-Rodriguez P , Gonzalez-Barreiro C , Simal-Gandara J , Valentao P , Carrasco-Pancorbo A , Andrade PB , Cancho-Grande B |
| Ref : Food Res Int , 106 :558 , 2018 |
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Abstract :
In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive disorder (MDD) and Parkinson's disease (PD) (monoamine oxidases: hMAO-A and hMAO-B respectively), and diabetes mellitus (DM) (alpha-glucosidase and alpha-amylase). 'Cornicabra' displayed the best inhibitory activity against all enzymes, when compared to 'Picual': BuChE (IC50=156+/-4 and 308+/-33mgmL(-1)), LOX (IC50=26+/-0.5 and 37+/-3mgmL(-1)), hMAO-A (IC50=20+/-2 and 37+/-0.2mgmL(-1)), hMAO-B (IC50=131+/-7 and 215+/-13mgmL(-1)) and alpha-glucosidase (IC50=154+/-17 and 251+/-31mgmL(-1)), respectively. The behaviour observed can be associated with the higher content of secoiridoids, lignans and phenolic acids in 'Cornicabra' EVOO. |
| PubMedSearch : Figueiredo-Gonzalez_2018_Food.Res.Int_106_558 |
| PubMedID: 29579961 |
Figueiredo-Gonzalez M, Reboredo-Rodriguez P, Gonzalez-Barreiro C, Simal-Gandara J, Valentao P, Carrasco-Pancorbo A, Andrade PB, Cancho-Grande B (2018)
Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays
Food Res Int
106 :558
Figueiredo-Gonzalez M, Reboredo-Rodriguez P, Gonzalez-Barreiro C, Simal-Gandara J, Valentao P, Carrasco-Pancorbo A, Andrade PB, Cancho-Grande B (2018)
Food Res Int
106 :558