| Title : Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading - Fortier_2004_Am.J.Physiol.Endocrinol.Metab_287_E282 |
| Author(s) : Fortier M , Wang SP , Mauriege P , Semache M , Mfuma L , Li H , Levy E , Richard D , Mitchell GA |
| Ref : American Journal of Physiology Endocrinol Metab , 287 :E282 , 2004 |
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Abstract :
In white adipose tissue, lipolysis can occur by hormone-sensitive lipase (HSL)-dependent or HSL-independent pathways. To study HSL-independent lipolysis, we placed HSL-deficient mice in conditions of increased fatty acid flux: beta-adrenergic stimulation, fasting, and dietary fat loading. Intraperitoneal administration of the beta(3)-adrenergic agonist CL-316243 caused a greater increase in nonesterified fatty acid level in controls (0.33 +/- 0.05 mmol/l) than in HSL(-/-) mice (0.12 +/- 0.01 mmol/l, P < 0.01). Similarly, in isolated adipocytes, lipolytic response to CL-316243 was greatly reduced in HSL(-/-) mice compared with controls. Fasting for |
| PubMedSearch : Fortier_2004_Am.J.Physiol.Endocrinol.Metab_287_E282 |
| PubMedID: 15271647 |
| Gene_locus related to this paper: mouse-hslip |
| Gene_locus | mouse-hslip |
Fortier M, Wang SP, Mauriege P, Semache M, Mfuma L, Li H, Levy E, Richard D, Mitchell GA (2004)
Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading
American Journal of Physiology Endocrinol Metab
287 :E282
Fortier M, Wang SP, Mauriege P, Semache M, Mfuma L, Li H, Levy E, Richard D, Mitchell GA (2004)
American Journal of Physiology Endocrinol Metab
287 :E282