mouse-hslip

Mus musculus mRNA for hormone sensitive lipase

Comment

Q9CTW2 Kawai differs only 1aa from P54310 || (from Uniprot) Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and of the fatty acid (FA) esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Preferentially hydrolyzes FA esters at the sn-3 position of the glycerol backbone in DAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Relationship

Family : Hormone-sensitive_lipase_like

Block : H

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MDLRTMTQSL VTLAEDNMAF FSSQGPGETA RRLSNVFAGV REQALGLEPT LGQLLGVAHH FDLDTETPAN GYRSLVHTAR CCLAHLLHKS RYVASNRKSI FFRASHNLAE LEAYLAALTQ LRAMAYYAQR LLTINRPGVL FFEGDEGLTA DFLQEYVTLH KGCFYGRCLG FQFTPAIRPF LQTLSIGLVS FGEHYKRNET GLSVTASSLF TGGRFAIDPE LRGAEFERII QNLDVHFWKA FWNITEIEVL SSLANMASTT VRVSRLLSLP PEAFEMPLTS DPRLTVTISP PLAHTGPAPV LARLISYDLR EGQDSKVLNS LAKSEGPRLD VRPRPHQAPR SRALVVHIHG GGFVAQTSKS HEPYLKNWAQ ELGVPIFSID YSLAPEAPFP RALEECFFAY CWAVKHCDLL GSTGERICLA GDSAGGNLCI TVSLRAAAYG VRVPDGIMAA YPVTTLQSSA SPSRLLSLMD PLLPLSVLSK CVSAYSGTEA EDHFDSDQKA LGVMGLVQRD TSLFLRDLRL GASSWLNSFP ELSGRKPQKT TSPTAESVRP TESMRRSVSE AALAQPEGLL GTDTLKKLTI KDLSNSEPSD SPEMSQSMET LGPSTPSDVN FFLRPGNSQE EAEAKDEVRP MDGVPRVRAA FPEGFHPRRS SQGVLHMPLY TSPIVKNPFM SPLLAPDSML KTLPPVHLVA CALDPMLDDS VMFARRLRDL GQPVTLKVVE DLPHGFLSLA ALCRETRQAT EFCVQRIRLI LTPPAAPLN

References (30)

Title : Genetic deletion of hormone-sensitive lipase in mice reduces cerebral blood flow but does not aggravate the impact of diet-induced obesity on memory - Skoug_2024_J.Neurochem__
Author(s) : Skoug C , Rogova O , Spegel P , Holm C , Duarte JMN
Ref : Journal of Neurochemistry , : , 2024
PubMedID: 38317494
Gene_locus related to this paper: mouse-hslip

Title : An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis - Zhang_2019_Cells_8_395
Author(s) : Zhang X , Zhang CC , Yang H , Soni KG , Wang SP , Mitchell GA , Wu JW
Ref : Cells , 8 :395 , 2019
PubMedID: 31035700
Gene_locus related to this paper: mouse-hslip

Title : Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice - Xu_2018_BMC.Cancer_18_797
Author(s) : Xu M , Chang HH , Jung X , Moro A , Chou CEN , King J , Hines OJ , Sinnett-Smith J , Rozengurt E , Eibl G
Ref : BMC Cancer , 18 :797 , 2018
PubMedID: 30086728
Gene_locus related to this paper: mouse-hslip

Title : Adipose Tissue Deficiency of Hormone-Sensitive Lipase Causes Fatty Liver in Mice - Xia_2017_PLoS.Genet_13_e1007110
Author(s) : Xia B , Cai GH , Yang H , Wang SP , Mitchell GA , Wu JW
Ref : PLoS Genet , 13 :e1007110 , 2017
PubMedID: 29232702
Gene_locus related to this paper: mouse-hslip

Title : Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice - Wu_2017_PLoS.Genet_13_e1006716
Author(s) : Wu JW , Preuss C , Wang SP , Yang H , Ji B , Carter GW , Gladdy R , Andelfinger G , Mitchell GA
Ref : PLoS Genet , 13 :e1006716 , 2017
PubMedID: 28459858
Gene_locus related to this paper: mouse-hslip

Title : The catalytic function of hormone-sensitive lipase is essential for fertility in male mice - Wang_2014_Endocrinology_155_3047
Author(s) : Wang SP , Wu JW , Bourdages H , Lefebvre JF , Casavant S , Leavitt BR , Labuda D , Trasler J , Smith CE , Hermo L , Mitchell GA
Ref : Endocrinology , 155 :3047 , 2014
PubMedID: 24797631
Gene_locus related to this paper: mouse-hslip

Title : Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass - Girousse_2013_PLoS.Biol_11_e1001485
Author(s) : Girousse A , Tavernier G , Valle C , Moro C , Mejhert N , Dinel AL , Houssier M , Roussel B , Besse-Patin A , Combes M , Mir L , Monbrun L , Bezaire V , Prunet-Marcassus B , Waget A , Vila I , Caspar-Bauguil S , Louche K , Marques MA , Mairal A , Renoud ML , Galitzky J , Holm C , Mouisel E , Thalamas C , Viguerie N , Sulpice T , Burcelin R , Arner P , Langin D
Ref : PLoS Biol , 11 :e1001485 , 2013
PubMedID: 23431266
Gene_locus related to this paper: mouse-hslip

Title : Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice - Obrowsky_2012_Biochim.Biophys.Acta_1821_1406
Author(s) : Obrowsky S , Chandak PG , Patankar JV , Pfeifer T , Povoden S , Schreiber R , Haemmerle G , Levak-Frank S , Kratky D
Ref : Biochimica & Biophysica Acta , 1821 :1406 , 2012
PubMedID: 22842588
Gene_locus related to this paper: mouse-hslip

Title : Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models - Girousse_2012_Int.J.Obes.(Lond)_36_581
Author(s) : Girousse A , Langin D
Ref : Int J Obes (Lond) , 36 :581 , 2012
PubMedID: 21673652
Gene_locus related to this paper: mouse-hslip

Title : Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice - Fernandez_2011_PLoS.One_6_e21603
Author(s) : Fernandez C , Schuhmann K , Herzog R , Fielding B , Frayn K , Shevchenko A , James P , Holm C , Strom K
Ref : PLoS ONE , 6 :e21603 , 2011
PubMedID: 21738729
Gene_locus related to this paper: mouse-hslip

Title : Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice - Pinent_2011_Endocrinology_152_2678
Author(s) : Pinent M , Prokesch A , Hackl H , Voshol PJ , Klatzer A , Walenta E , Panzenboeck U , Kenner L , Trajanoski Z , Hoefler G , Bogner-Strauss JG
Ref : Endocrinology , 152 :2678 , 2011
PubMedID: 21540289
Gene_locus related to this paper: mouse-hslip

Title : Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility - Hermo_2008_Mol.Reprod.Dev_75_565
Author(s) : Hermo L , Chung S , Gregory M , Smith CE , Wang SP , El-Alfy M , Cyr DG , Mitchell GA , Trasler J
Ref : Mol Reprod Dev , 75 :565 , 2008
PubMedID: 17886267
Gene_locus related to this paper: mouse-hslip

Title : Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart - Park_2005_Am.J.Physiol.Endocrinol.Metab_289_E30
Author(s) : Park SY , Kim HJ , Wang S , Higashimori T , Dong J , Kim YJ , Cline G , Li H , Prentki M , Shulman GI , Mitchell GA , Kim JK
Ref : American Journal of Physiology Endocrinol Metab , 289 :E30 , 2005
PubMedID: 15701680
Gene_locus related to this paper: mouse-hslip

Title : Human hormone-sensitive lipase (HSL): expression in white fat corrects the white adipose phenotype of HSL-deficient mice - Fortier_2005_J.Lipid.Res_46_1860
Author(s) : Fortier M , Soni K , Laurin N , Wang SP , Mauriege P , Jirik FR , Mitchell GA
Ref : J Lipid Res , 46 :1860 , 2005
PubMedID: 15961788
Gene_locus related to this paper: mouse-hslip

Title : Expression of human hormone-sensitive lipase (HSL) in postmeiotic germ cells confers normal fertility to HSL-deficient mice - Wang_2004_Endocrinology_145_5688
Author(s) : Wang SP , Chung S , Soni K , Bourdages H , Hermo L , Trasler J , Mitchell GA
Ref : Endocrinology , 145 :5688 , 2004
PubMedID: 15345679
Gene_locus related to this paper: mouse-hslip

Title : Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading - Fortier_2004_Am.J.Physiol.Endocrinol.Metab_287_E282
Author(s) : Fortier M , Wang SP , Mauriege P , Semache M , Mfuma L , Li H , Levy E , Richard D , Mitchell GA
Ref : American Journal of Physiology Endocrinol Metab , 287 :E282 , 2004
PubMedID: 15271647
Gene_locus related to this paper: mouse-hslip

Title : Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1 - Peyot_2004_Diabetes_53_1733
Author(s) : Peyot ML , Nolan CJ , Soni K , Joly E , Lussier R , Corkey BE , Wang SP , Mitchell GA , Prentki M
Ref : Diabetes , 53 :1733 , 2004
PubMedID: 15220197
Gene_locus related to this paper: mouse-hslip

Title : Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice - Voshol_2003_Endocrinology_144_3456
Author(s) : Voshol PJ , Haemmerle G , Ouwens DM , Zimmermann R , Zechner R , Teusink B , Maassen JA , Havekes LM , Romijn JA
Ref : Endocrinology , 144 :3456 , 2003
PubMedID: 12865325
Gene_locus related to this paper: mouse-hslip

Title : Hormone-sensitive lipase deficiency in mice causes lipid storage in the adrenal cortex and impaired corticosterone response to corticotropin stimulation - Li_2002_Endocrinology_143_3333
Author(s) : Li H , Brochu M , Wang SP , Rochdi L , Cote M , Mitchell G , Gallo-Payet N
Ref : Endocrinology , 143 :3333 , 2002
PubMedID: 12193545
Gene_locus related to this paper: mouse-hslip

Title : Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs - Okazaki_2002_Nature_420_563
Author(s) : Okazaki Y , Furuno M , Kasukawa T , Adachi J , Bono H , Kondo S , Nikaido I , Osato N , Saito R , Suzuki H , Yamanaka I , Kiyosawa H , Yagi K , Tomaru Y , Hasegawa Y , Nogami A , Schonbach C , Gojobori T , Baldarelli R , Hill DP , Bult C , Hume DA , Quackenbush J , Schriml LM , Kanapin A , Matsuda H , Batalov S , Beisel KW , Blake JA , Bradt D , Brusic V , Chothia C , Corbani LE , Cousins S , Dalla E , Dragani TA , Fletcher CF , Forrest A , Frazer KS , Gaasterland T , Gariboldi M , Gissi C , Godzik A , Gough J , Grimmond S , Gustincich S , Hirokawa N , Jackson IJ , Jarvis ED , Kanai A , Kawaji H , Kawasawa Y , Kedzierski RM , King BL , Konagaya A , Kurochkin IV , Lee Y , Lenhard B , Lyons PA , Maglott DR , Maltais L , Marchionni L , McKenzie L , Miki H , Nagashima T , Numata K , Okido T , Pavan WJ , Pertea G , Pesole G , Petrovsky N , Pillai R , Pontius JU , Qi D , Ramachandran S , Ravasi T , Reed JC , Reed DJ , Reid J , Ring BZ , Ringwald M , Sandelin A , Schneider C , Semple CA , Setou M , Shimada K , Sultana R , Takenaka Y , Taylor MS , Teasdale RD , Tomita M , Verardo R , Wagner L , Wahlestedt C , Wang Y , Watanabe Y , Wells C , Wilming LG , Wynshaw-Boris A , Yanagisawa M , Yang I , Yang L , Yuan Z , Zavolan M , Zhu Y , Zimmer A , Carninci P , Hayatsu N , Hirozane-Kishikawa T , Konno H , Nakamura M , Sakazume N , Sato K , Shiraki T , Waki K , Kawai J , Aizawa K , Arakawa T , Fukuda S , Hara A , Hashizume W , Imotani K , Ishii Y , Itoh M , Kagawa I , Miyazaki A , Sakai K , Sasaki D , Shibata K , Shinagawa A , Yasunishi A , Yoshino M , Waterston R , Lander ES , Rogers J , Birney E , Hayashizaki Y
Ref : Nature , 420 :563 , 2002
PubMedID: 12466851
Gene_locus related to this paper: mouse-1lipg , mouse-1llip , mouse-1plrp , mouse-3neur , mouse-ABH15 , mouse-abhd4 , mouse-abhd5 , mouse-Abhd8 , mouse-Abhd11 , mouse-abhda , mouse-acot4 , mouse-adcl4 , mouse-AI607300 , mouse-BAAT , mouse-bphl , mouse-C87498 , mouse-Ldah , mouse-Ces1d , mouse-Ces2e , mouse-CMBL , mouse-DGLB , mouse-dpp9 , mouse-ES10 , mouse-F135A , mouse-FASN , mouse-hslip , mouse-hyes , mouse-Kansl3 , mouse-LIPH , mouse-LIPK , mouse-lipli , mouse-LIPM , mouse-lypla1 , mouse-lypla2 , mouse-MEST , mouse-MGLL , mouse-ndr4 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-ppce , mouse-Ppgb , mouse-PPME1 , mouse-q3uuq7 , mouse-Q8BLF1 , mouse-ACOT6 , mouse-Q8C1A9 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-Q8BGG9 , mouse-Q8C167 , mouse-rbbp9 , mouse-SERHL , mouse-tssp

Title : Infertility and testicular defects in hormone-sensitive lipase-deficient mice - Chung_2001_Endocrinology_142_4272
Author(s) : Chung S , Wang SP , Pan L , Mitchell G , Trasler J , Hermo L
Ref : Endocrinology , 142 :4272 , 2001
PubMedID: 11564684
Gene_locus related to this paper: mouse-hslip

Title : A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in hormone-sensitive lipase-deficient mice - Roduit_2001_Diabetes_50_1970
Author(s) : Roduit R , Masiello P , Wang SP , Li H , Mitchell GA , Prentki M
Ref : Diabetes , 50 :1970 , 2001
PubMedID: 11522661
Gene_locus related to this paper: mouse-hslip

Title : The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice - Wang_2001_Obes.Res_9_119
Author(s) : Wang SP , Laurin N , Himms-Hagen J , Rudnicki MA , Levy E , Robert MF , Pan L , Oligny L , Mitchell GA
Ref : Obes Res , 9 :119 , 2001
PubMedID: 11316346
Gene_locus related to this paper: mouse-hslip

Title : Functional annotation of a full-length mouse cDNA collection - Kawai_2001_Nature_409_685
Author(s) : Kawai J , Shinagawa A , Shibata K , Yoshino M , Itoh M , Ishii Y , Arakawa T , Hara A , Fukunishi Y , Konno H , Adachi J , Fukuda S , Aizawa K , Izawa M , Nishi K , Kiyosawa H , Kondo S , Yamanaka I , Saito T , Okazaki Y , Gojobori T , Bono H , Kasukawa T , Saito R , Kadota K , Matsuda H , Ashburner M , Batalov S , Casavant T , Fleischmann W , Gaasterland T , Gissi C , King B , Kochiwa H , Kuehl P , Lewis S , Matsuo Y , Nikaido I , Pesole G , Quackenbush J , Schriml LM , Staubli F , Suzuki R , Tomita M , Wagner L , Washio T , Sakai K , Okido T , Furuno M , Aono H , Baldarelli R , Barsh G , Blake J , Boffelli D , Bojunga N , Carninci P , de Bonaldo MF , Brownstein MJ , Bult C , Fletcher C , Fujita M , Gariboldi M , Gustincich S , Hill D , Hofmann M , Hume DA , Kamiya M , Lee NH , Lyons P , Marchionni L , Mashima J , Mazzarelli J , Mombaerts P , Nordone P , Ring B , Ringwald M , Rodriguez I , Sakamoto N , Sasaki H , Sato K , Schonbach C , Seya T , Shibata Y , Storch KF , Suzuki H , Toyo-oka K , Wang KH , Weitz C , Whittaker C , Wilming L , Wynshaw-Boris A , Yoshida K , Hasegawa Y , Kawaji H , Kohtsuki S , Hayashizaki Y
Ref : Nature , 409 :685 , 2001
PubMedID: 11217851
Gene_locus related to this paper: mouse-1lipg , mouse-1plip , mouse-1plrp , mouse-ABH15 , mouse-abhd5 , mouse-ABHD6 , mouse-Abhd8 , mouse-aryla , mouse-bphl , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-EPHX1 , mouse-ES10 , mouse-hslip , mouse-hyes , mouse-ABHD2 , mouse-lcat , mouse-lipli , mouse-LIPN , mouse-lypla1 , mouse-lypla2 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-Ppgb , mouse-PPME1 , mouse-ppt , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-RISC , mouse-SERHL , mouse-SPG21 , mouse-Tex30

Title : Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes - Carninci_2000_Genome.Res_10_1617
Author(s) : Carninci P , Shibata Y , Hayatsu N , Sugahara Y , Shibata K , Itoh M , Konno H , Okazaki Y , Muramatsu M , Hayashizaki Y
Ref : Genome Res , 10 :1617 , 2000
PubMedID: 11042159
Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-hyes , mouse-lipli , mouse-LIPN , mouse-pafa , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC

Title : RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer - Shibata_2000_Genome.Res_10_1757
Author(s) : Shibata K , Itoh M , Aizawa K , Nagaoka S , Sasaki N , Carninci P , Konno H , Akiyama J , Nishi K , Kitsunai T , Tashiro H , Sumi N , Ishii Y , Nakamura S , Hazama M , Nishine T , Harada A , Yamamoto R , Matsumoto H , Sakaguchi S , Ikegami T , Kashiwagi K , Fujiwake S , Inoue K , Togawa Y
Ref : Genome Res , 10 :1757 , 2000
PubMedID: 11076861
Gene_locus related to this paper: mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-dpp8 , mouse-hslip , mouse-lipli , mouse-LIPN , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6

Title : Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity - Osuga_2000_Proc.Natl.Acad.Sci.U.S.A_97_787
Author(s) : Osuga J , Ishibashi S , Oka T , Yagyu H , Tozawa R , Fujimoto A , Shionoiri F , Yahagi N , Kraemer FB , Tsutsumi O , Yamada N
Ref : Proc Natl Acad Sci U S A , 97 :787 , 2000
PubMedID: 10639158
Gene_locus related to this paper: human-LIPE , mouse-hslip

Title : High-efficiency full-length cDNA cloning -
Author(s) : Carninci P , Hayashizaki Y
Ref : Methods Enzymol , 303 :19 , 1999
PubMedID: 10349636
Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-lipli , mouse-LIPN , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC

Title : Hormone-sensitive lipase (Lipe): sequence analysis of the 129Sv mouse Lipe gene - Sztrolovics_1997_Mamm.Genome_8_86
Author(s) : Sztrolovics R , Wang SP , Lapierre P , Chen HS , Robert MF , Mitchell GA
Ref : Mamm Genome , 8 :86 , 1997
PubMedID: 9060404
Gene_locus related to this paper: mouse-hslip

Title : Isolation and characterization of the gene for mouse hormone-sensitive lipase - Li_1994_Genomics_24_259
Author(s) : Li Z , Sumida M , Birchbauer A , Schotz MC , Reue K
Ref : Genomics , 24 :259 , 1994
PubMedID: 7698747
Gene_locus related to this paper: mouse-hslip