| Title : Comparison of the delayed neurotoxicity of O-methyl and O-ethyl analogs of EPN, leptophos, and cyanofenphos - Francis_1982_J.Environ.Sci.Health.B_17_611 |
| Author(s) : Francis BM , Hansen LG , Metcalf RA , Metcalf RL |
| Ref : J Environ Sci Health B , 17 :611 , 1982 |
|
Abstract :
Eight pairs of O-methyl and O-ethyl O-(substituted-phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. O-methyl compounds were in all cases more active than their O-ethyl analogs. The neurotoxic potential of the O-methyl phenylphosphonothionates was 2,5-diCl greater than 4-NO2 greater than 2,4,5-triCl and 2,4,6-triCl greater than 2,4-diCl greater than 2,5-diCl-4-Br greater than 4-CN, when single oral doses were given. Both EPN-ethyl and leptophos-methyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD50s for mice and flies were established. |
| PubMedSearch : Francis_1982_J.Environ.Sci.Health.B_17_611 |
| PubMedID: 7166625 |
| Inhibitor | Cyanofenphos |
Francis BM, Hansen LG, Metcalf RA, Metcalf RL (1982)
Comparison of the delayed neurotoxicity of O-methyl and O-ethyl analogs of EPN, leptophos, and cyanofenphos
J Environ Sci Health B
17 :611
Francis BM, Hansen LG, Metcalf RA, Metcalf RL (1982)
J Environ Sci Health B
17 :611