| Title : Generation of anti-beta-amyloid antibodies via phage display technology - Frenkel_2004_Vaccine_22_2505 |
| Author(s) : Frenkel D , Dori M , Solomon B |
| Ref : Vaccine , 22 :2505 , 2004 |
|
Abstract :
The EFRH sequence, found to be the main anti-aggregating epitope corresponding to amino acids 3-6 of beta-amyloid peptide (AbetaP), was displayed on a phage and used as an antigen for immunization of mice, guinea pigs and rabbits. The generated antibodies recognize the full-length AbetaP (1-40) and exhibit similar biological properties to antibodies raised against whole soluble peptide and/or fibrillar beta-amyloid. EFRH-phage immunization of a transgenic mouse model of Alzheimer's disease evokes antibodies able to dissolve already formed beta-amyloid plaques, suggesting that they could become a therapeutic approach in treatment of the disease. |
| PubMedSearch : Frenkel_2004_Vaccine_22_2505 |
| PubMedID: 15193416 |
Frenkel D, Dori M, Solomon B (2004)
Generation of anti-beta-amyloid antibodies via phage display technology
Vaccine
22 :2505
Frenkel D, Dori M, Solomon B (2004)
Vaccine
22 :2505