Frenkel D

General

Full name : Frenkel Dan

First name : Dan

Mail : Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel\; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv

Zip Code :

City :

Country : Israel

Email : dfrenkel@post.tau.ac.il

Phone :

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Website :

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References (48)

Title : The dialog between neurons and microglia in Alzheimer's disease: The neurotransmitters view - Stolero_2021_J.Neurochem_158_1412
Author(s) : Stolero N , Frenkel D
Ref : Journal of Neurochemistry , 158 :1412 , 2021
Abstract :
PubMedSearch : Stolero_2021_J.Neurochem_158_1412
PubMedID: 33314073

Title : Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE\/BuChE inhibitor in scopolamine mouse model and inflammatory cells - Liu_2017_Neuropharmacol_113_445
Author(s) : Liu W , Rabinovich A , Nash Y , Frenkel D , Wang Y , Youdim MB , Weinreb O
Ref : Neuropharmacology , 113 :445 , 2017
Abstract :
PubMedSearch : Liu_2017_Neuropharmacol_113_445
PubMedID: 27984078

Title : Impaired Autophagy in APOE4 Astrocytes - Simonovitch_2016_J.Alzheimers.Dis_51_915
Author(s) : Simonovitch S , Schmukler E , Bespalko A , Iram T , Frenkel D , Holtzman DM , Masliah E , Michaelson DM , Pinkas-Kramarski R
Ref : J Alzheimers Dis , 51 :915 , 2016
Abstract :
PubMedSearch : Simonovitch_2016_J.Alzheimers.Dis_51_915
PubMedID: 26923027

Title : Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes - Iram_2016_J.Neurosci_36_5185
Author(s) : Iram T , Ramirez-Ortiz Z , Byrne MH , Coleman UA , Kingery ND , Means TK , Frenkel D , El Khoury J
Ref : Journal of Neuroscience , 36 :5185 , 2016
Abstract :
PubMedSearch : Iram_2016_J.Neurosci_36_5185
PubMedID: 27170117

Title : Astrocytes from old Alzheimer's disease mice are impaired in Abeta uptake and in neuroprotection - Iram_2016_Neurobiol.Dis_96_84
Author(s) : Iram T , Trudler D , Kain D , Kanner S , Galron R , Vassar R , Barzilai A , Blinder P , Fishelson Z , Frenkel D
Ref : Neurobiol Dis , 96 :84 , 2016
Abstract :
PubMedSearch : Iram_2016_Neurobiol.Dis_96_84
PubMedID: 27544484

Title : New insights on Parkinson's disease genes: the link between mitochondria impairment and neuroinflammation - Trudler_2015_J.Neural.Transm.(Vienna)_122_1409
Author(s) : Trudler D , Nash Y , Frenkel D
Ref : J Neural Transm (Vienna) , 122 :1409 , 2015
Abstract :
PubMedSearch : Trudler_2015_J.Neural.Transm.(Vienna)_122_1409
PubMedID: 25894287

Title : Low-level laser therapy ameliorates disease progression in a mouse model of Alzheimer's disease - Farfara_2015_J.Mol.Neurosci_55_430
Author(s) : Farfara D , Tuby H , Trudler D , Doron-Mandel E , Maltz L , Vassar RJ , Frenkel D , Oron U
Ref : Journal of Molecular Neuroscience , 55 :430 , 2015
Abstract :
PubMedSearch : Farfara_2015_J.Mol.Neurosci_55_430
PubMedID: 24994540

Title : A new TRAIL in Alzheimer's disease therapy -
Author(s) : Frenkel D
Ref : Brain , 138 :8 , 2015
PubMedID: 25564490

Title : Insulin-coated gold nanoparticles as a new concept for personalized and adjustable glucose regulation - Shilo_2015_Nanoscale_7_20489
Author(s) : Shilo M , Berenstein P , Dreifuss T , Nash Y , Goldsmith G , Kazimirsky G , Motiei M , Frenkel D , Brodie C , Popovtzer R
Ref : Nanoscale , 7 :20489 , 2015
Abstract :
PubMedSearch : Shilo_2015_Nanoscale_7_20489
PubMedID: 26583784

Title : DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline - Trudler_2014_J.Neurochem_129_434
Author(s) : Trudler D , Weinreb O , Mandel SA , Youdim MB , Frenkel D
Ref : Journal of Neurochemistry , 129 :434 , 2014
Abstract :
PubMedSearch : Trudler_2014_J.Neurochem_129_434
PubMedID: 24355073

Title : Alginate-coated magnetic nanoparticles for noninvasive MRI of extracellular calcium - Bar-Shir_2014_NMR.Biomed_27_774
Author(s) : Bar-Shir A , Avram L , Yariv-Shoushan S , Anaby D , Cohen S , Segev-Amzaleg N , Frenkel D , Sadan O , Offen D , Cohen Y
Ref : NMR Biomed , 27 :774 , 2014
Abstract :
PubMedSearch : Bar-Shir_2014_NMR.Biomed_27_774
PubMedID: 24764262

Title : Neuropsychiatric symptoms in dementia-a role for neuroinflammation? - Holmgren_2014_Brain.Res.Bull_108_88
Author(s) : Holmgren S , Hjorth E , Schultzberg M , Larksater M , Frenkel D , Tysen-Backstrom AC , Aarsland D , Freund-Levi Y
Ref : Brain Research Bulletin , 108 :88 , 2014
Abstract :
PubMedSearch : Holmgren_2014_Brain.Res.Bull_108_88
PubMedID: 25224917

Title : Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE - Levy_2014_Exp.Neurol_255_63
Author(s) : Levy Barazany H , Barazany D , Puckett L , Blanga-Kanfi S , Borenstein-Auerbach N , Yang K , Peron JP , Weiner HL , Frenkel D
Ref : Experimental Neurology , 255 :63 , 2014
Abstract :
PubMedSearch : Levy_2014_Exp.Neurol_255_63
PubMedID: 24552689

Title : Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats - Lotan_2014_Brain.Behav.Immun_38_249
Author(s) : Lotan D , Benhar I , Alvarez K , Mascaro-Blanco A , Brimberg L , Frenkel D , Cunningham MW , Joel D
Ref : Brain Behavior & Immunity , 38 :249 , 2014
Abstract :
PubMedSearch : Lotan_2014_Brain.Behav.Immun_38_249
PubMedID: 24561489

Title : Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies - Avrahami_2013_J.Biol.Chem_288_1295
Author(s) : Avrahami L , Farfara D , Shaham-Kol M , Vassar R , Frenkel D , Eldar-Finkelman H
Ref : Journal of Biological Chemistry , 288 :1295 , 2013
Abstract :
PubMedSearch : Avrahami_2013_J.Biol.Chem_288_1295
PubMedID: 23155049

Title : Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression - Frenkel_2013_Nat.Commun_4_2030
Author(s) : Frenkel D , Wilkinson K , Zhao L , Hickman SE , Means TK , Puckett L , Farfara D , Kingery ND , Weiner HL , El Khoury J
Ref : Nat Commun , 4 :2030 , 2013
Abstract :
PubMedSearch : Frenkel_2013_Nat.Commun_4_2030
PubMedID: 23799536

Title : Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model - Lifshitz_2013_Brain.Behav.Immun_30_143
Author(s) : Lifshitz V , Benromano T , Weiss R , Blanga-Kanfi S , Frenkel D
Ref : Brain Behavior & Immunity , 30 :143 , 2013
Abstract :
PubMedSearch : Lifshitz_2013_Brain.Behav.Immun_30_143
PubMedID: 23257117

Title : Scavenger receptor A deficiency accelerates cerebrovascular amyloidosis in an animal model - Lifshitz_2013_J.Mol.Neurosci_50_198
Author(s) : Lifshitz V , Weiss R , Levy H , Frenkel D
Ref : Journal of Molecular Neuroscience , 50 :198 , 2013
Abstract :
PubMedSearch : Lifshitz_2013_J.Mol.Neurosci_50_198
PubMedID: 23108486

Title : Preconditioning to mild oxidative stress mediates astroglial neuroprotection in an IL-10-dependent manner - Segev-Amzaleg_2013_Brain.Behav.Immun_30_176
Author(s) : Segev-Amzaleg N , Trudler D , Frenkel D
Ref : Brain Behavior & Immunity , 30 :176 , 2013
Abstract :
PubMedSearch : Segev-Amzaleg_2013_Brain.Behav.Immun_30_176
PubMedID: 23313057

Title : Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria - Adler-Abramovich_2012_Nat.Chem.Biol_8_701
Author(s) : Adler-Abramovich L , Vaks L , Carny O , Trudler D , Magno A , Caflisch A , Frenkel D , Gazit E
Ref : Nat Chemical Biology , 8 :701 , 2012
Abstract :
PubMedSearch : Adler-Abramovich_2012_Nat.Chem.Biol_8_701
PubMedID: 22706200

Title : Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain - Kirshner_2012_J.Mol.Neurosci_46_554
Author(s) : Kirshner M , Galron R , Frenkel D , Mandelbaum G , Shiloh Y , Wang ZQ , Barzilai A
Ref : Journal of Molecular Neuroscience , 46 :554 , 2012
Abstract :
PubMedSearch : Kirshner_2012_J.Mol.Neurosci_46_554
PubMedID: 21922345

Title : Expression of scavenger receptor A on antigen presenting cells is important for CD4+ T-cells proliferation in EAE mouse model - Levy-Barazany_2012_J.Neuroinflammation_9_120
Author(s) : Levy-Barazany H , Frenkel D
Ref : J Neuroinflammation , 9 :120 , 2012
Abstract :
PubMedSearch : Levy-Barazany_2012_J.Neuroinflammation_9_120
PubMedID: 22676725

Title : Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model - Lifshitz_2012_Neurobiol.Aging_33_432 e1
Author(s) : Lifshitz V , Weiss R , Benromano T , Kfir E , Blumenfeld-Katzir T , Tempel-Brami C , Assaf Y , Xia W , Wyss-Coray T , Weiner HL , Frenkel D
Ref : Neurobiology of Aging , 33 :432 e1 , 2012
Abstract :
PubMedSearch : Lifshitz_2012_Neurobiol.Aging_33_432 e1
PubMedID: 21371785

Title : The role of the neuro-astro-vascular unit in the etiology of ataxia telangiectasia - Meshulam_2012_Front.Pharmacol_3_157
Author(s) : Meshulam L , Galron R , Kanner S , De Pitta M , Bonifazi P , Goldin M , Frenkel D , Ben-Jacob E , Barzilai A
Ref : Front Pharmacol , 3 :157 , 2012
Abstract :
PubMedSearch : Meshulam_2012_Front.Pharmacol_3_157
PubMedID: 23060792

Title : Naphthoquinone-tyrptophan reduces neurotoxic Abeta*56 levels and improves cognition in Alzheimer's disease animal model - Scherzer-Attali_2012_Neurobiol.Dis_46_663
Author(s) : Scherzer-Attali R , Farfara D , Cooper I , Levin A , Ben-Romano T , Trudler D , Vientrov M , Shaltiel-Karyo R , Shalev DE , Segev-Amzaleg N , Gazit E , Segal D , Frenkel D
Ref : Neurobiol Dis , 46 :663 , 2012
Abstract :
PubMedSearch : Scherzer-Attali_2012_Neurobiol.Dis_46_663
PubMedID: 22449754

Title : TGF-beta1 affects endothelial cell interaction with macrophages and T cells leading to the development of cerebrovascular amyloidosis - Weiss_2011_Brain.Behav.Immun_25_1017
Author(s) : Weiss R , Lifshitz V , Frenkel D
Ref : Brain Behavior & Immunity , 25 :1017 , 2011
Abstract :
PubMedSearch : Weiss_2011_Brain.Behav.Immun_25_1017
PubMedID: 21112386

Title : gamma-Secretase component presenilin is important for microglia beta-amyloid clearance - Farfara_2011_Ann.Neurol_69_170
Author(s) : Farfara D , Trudler D , Segev-Amzaleg N , Galron R , Stein R , Frenkel D
Ref : Annals of Neurology , 69 :170 , 2011
Abstract :
PubMedSearch : Farfara_2011_Ann.Neurol_69_170
PubMedID: 21280087

Title : Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models - Frydman-Marom_2011_PLoS.One_6_e16564
Author(s) : Frydman-Marom A , Levin A , Farfara D , Benromano T , Scherzer-Attali R , Peled S , Vassar R , Segal D , Gazit E , Frenkel D , Ovadia M
Ref : PLoS ONE , 6 :e16564 , 2011
Abstract :
PubMedSearch : Frydman-Marom_2011_PLoS.One_6_e16564
PubMedID: 21305046

Title : Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model - Galron_2011_J.Mol.Neurosci_45_202
Author(s) : Galron R , Gruber R , Lifshitz V , Lu H , Kirshner M , Ziv N , Wang ZQ , Shiloh Y , Barzilai A , Frenkel D
Ref : Journal of Molecular Neuroscience , 45 :202 , 2011
Abstract :
PubMedSearch : Galron_2011_J.Mol.Neurosci_45_202
PubMedID: 21279473

Title : CpG-C immunotherapeutic efficacy is jeopardized by ongoing exposure to stress: potential implications for clinical use - Goldfarb_2011_Brain.Behav.Immun_25_67
Author(s) : Goldfarb Y , Levi B , Sorski L , Frenkel D , Ben-Eliyahu S
Ref : Brain Behavior & Immunity , 25 :67 , 2011
Abstract :
PubMedSearch : Goldfarb_2011_Brain.Behav.Immun_25_67
PubMedID: 20656015

Title : A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia - Raz-Prag_2011_Am.J.Pathol_179_1533
Author(s) : Raz-Prag D , Galron R , Segev-Amzaleg N , Solomon AS , Shiloh Y , Barzilai A , Frenkel D
Ref : American Journal of Pathology , 179 :1533 , 2011
Abstract :
PubMedSearch : Raz-Prag_2011_Am.J.Pathol_179_1533
PubMedID: 21763675

Title : Immunotherapy for Alzheimer's disease - Solomon_2010_Neuropharmacol_59_303
Author(s) : Solomon B , Frenkel D
Ref : Neuropharmacology , 59 :303 , 2010
Abstract :
PubMedSearch : Solomon_2010_Neuropharmacol_59_303
PubMedID: 20388523

Title : Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application - Trudler_2010_Mediators.Inflamm_2010_
Author(s) : Trudler D , Farfara D , Frenkel D
Ref : Mediators Inflamm , 2010 : , 2010
Abstract :
PubMedSearch : Trudler_2010_Mediators.Inflamm_2010_
PubMedID: 20706642

Title : Characterization of brain lesions in a mouse model of progressive multiple sclerosis - Levy_2010_Exp.Neurol_226_148
Author(s) : Levy H , Assaf Y , Frenkel D
Ref : Experimental Neurology , 226 :148 , 2010
Abstract :
PubMedSearch : Levy_2010_Exp.Neurol_226_148
PubMedID: 20736006

Title : Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease - Farfara_2008_J.Cell.Mol.Med_12_762
Author(s) : Farfara D , Lifshitz V , Frenkel D
Ref : J Cell Mol Med , 12 :762 , 2008
Abstract :
PubMedSearch : Farfara_2008_J.Cell.Mol.Med_12_762
PubMedID: 18363841

Title : Generation of anti-beta-amyloid antibodies via phage display technology - Frenkel_2004_Vaccine_22_2505
Author(s) : Frenkel D , Dori M , Solomon B
Ref : Vaccine , 22 :2505 , 2004
Abstract :
PubMedSearch : Frenkel_2004_Vaccine_22_2505
PubMedID: 15193416

Title : Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization - Frenkel_2003_Vaccine_21_1060
Author(s) : Frenkel D , Dewachter I , Van Leuven F , Solomon B
Ref : Vaccine , 21 :1060 , 2003
Abstract :
PubMedSearch : Frenkel_2003_Vaccine_21_1060
PubMedID: 12559780

Title : Effect of proton pump inhibitors on the continuous real time (13)C-urea breath test - Shirin_2003_Am.J.Gastroenterol_98_46
Author(s) : Shirin H , Frenkel D , Shevah O , Levine A , Bruck R , Moss SF , Niv Y , Avni Y
Ref : Am J Gastroenterol , 98 :46 , 2003
Abstract :
PubMedSearch : Shirin_2003_Am.J.Gastroenterol_98_46
PubMedID: 12526935

Title : Generation and brain delivery of anti-aggregating antibodies against beta-amyloid plaques using phage display technology - Solomon_2002_J.Neural.Transm.Suppl__321
Author(s) : Solomon B , Frenkel D
Ref : J Neural Transm Suppl , :321 , 2002
Abstract :
PubMedSearch : Solomon_2002_J.Neural.Transm.Suppl__321
PubMedID: 12456075

Title : Filamentous phage as vector-mediated antibody delivery to the brain - Frenkel_2002_Proc.Natl.Acad.Sci.U.S.A_99_5675
Author(s) : Frenkel D , Solomon B
Ref : Proc Natl Acad Sci U S A , 99 :5675 , 2002
Abstract :
PubMedSearch : Frenkel_2002_Proc.Natl.Acad.Sci.U.S.A_99_5675
PubMedID: 11960022

Title : Generation of auto-antibodies towards Alzheimer's disease vaccination - Frenkel_2001_Vaccine_19_2615
Author(s) : Frenkel D , Kariv N , Solomon B
Ref : Vaccine , 19 :2615 , 2001
Abstract :
PubMedSearch : Frenkel_2001_Vaccine_19_2615
PubMedID: 11257400

Title : Towards Alzheimer's beta-amyloid vaccination - Frenkel_2001_Biologicals_29_243
Author(s) : Frenkel D , Solomon B
Ref : Biologicals , 29 :243 , 2001
Abstract :
PubMedSearch : Frenkel_2001_Biologicals_29_243
PubMedID: 11851323

Title : Vaccination for the prevention and treatment of Alzheimer's disease - Solomon_2000_Drugs.Today.(Barc)_36_655
Author(s) : Solomon B , Frenkel D
Ref : Drugs Today (Barc) , 36 :655 , 2000
Abstract :
PubMedSearch : Solomon_2000_Drugs.Today.(Barc)_36_655
PubMedID: 12847570

Title : Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration - Frenkel_2000_Proc.Natl.Acad.Sci.U.S.A_97_11455
Author(s) : Frenkel D , Katz O , Solomon B
Ref : Proc Natl Acad Sci U S A , 97 :11455 , 2000
Abstract :
PubMedSearch : Frenkel_2000_Proc.Natl.Acad.Sci.U.S.A_97_11455
PubMedID: 11027345

Title : Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody - Frenkel_2000_J.Neuroimmunol_106_23
Author(s) : Frenkel D , Solomon B , Benhar I
Ref : Journal of Neuroimmunology , 106 :23 , 2000
Abstract :
PubMedSearch : Frenkel_2000_J.Neuroimmunol_106_23
PubMedID: 10814779

Title : Matrix-assisted refolding of single-chain Fv- cellulose binding domain fusion proteins - Berdichevsky_1999_Protein.Expr.Purif_17_249
Author(s) : Berdichevsky Y , Lamed R , Frenkel D , Gophna U , Bayer EA , Yaron S , Shoham Y , Benhar I
Ref : Protein Expr Purif , 17 :249 , 1999
Abstract :
PubMedSearch : Berdichevsky_1999_Protein.Expr.Purif_17_249
PubMedID: 10545273

Title : High affinity binding of monoclonal antibodies to the sequential epitope EFRH of beta-amyloid peptide is essential for modulation of fibrillar aggregation - Frenkel_1999_J.Neuroimmunol_95_136
Author(s) : Frenkel D , Balass M , Katchalski-Katzir E , Solomon B
Ref : Journal of Neuroimmunology , 95 :136 , 1999
Abstract :
PubMedSearch : Frenkel_1999_J.Neuroimmunol_95_136
PubMedID: 10229123

Title : N-terminal EFRH sequence of Alzheimer's beta-amyloid peptide represents the epitope of its anti-aggregating antibodies - Frenkel_1998_J.Neuroimmunol_88_85
Author(s) : Frenkel D , Balass M , Solomon B
Ref : Journal of Neuroimmunology , 88 :85 , 1998
Abstract :
PubMedSearch : Frenkel_1998_J.Neuroimmunol_88_85
PubMedID: 9688328