| Title : Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression - Frenkel_2013_Nat.Commun_4_2030 |
| Author(s) : Frenkel D , Wilkinson K , Zhao L , Hickman SE , Means TK , Puckett L , Farfara D , Kingery ND , Weiner HL , El Khoury J |
| Ref : Nat Commun , 4 :2030 , 2013 |
|
Abstract :
In Alzheimer's disease, soluble amyloid-beta causes synaptic dysfunction and neuronal loss. Receptors involved in clearance of soluble amyloid-beta are not known. Here we use short hairpin RNA screening and identify the scavenger receptor Scara1 as a receptor for soluble amyloid-beta expressed on myeloid cells. To determine the role of Scara1 in clearance of soluble amyloid-beta in vivo, we cross Scara1 null mice with PS1-APP mice, a mouse model of Alzheimer's disease, and generate PS1-APP-Scara1-deficient mice. Scara1 deficiency markedly accelerates Abeta accumulation, leading to increased mortality. In contrast, pharmacological upregulation of Scara1 expression on mononuclear phagocytes increases Abeta clearance. This approach is a potential treatment strategy for Alzheimer's disease. |
| PubMedSearch : Frenkel_2013_Nat.Commun_4_2030 |
| PubMedID: 23799536 |
Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J (2013)
Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
Nat Commun
4 :2030
Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J (2013)
Nat Commun
4 :2030