| Title : Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease - Geib_1991_Acta.Crystallogr_C824 |
| Author(s) : Geib SJ , Tuckmantel W , Kozikowski AP |
| Ref : Acta Crystallographica , C47 pt4 :824 , 1991 |
|
Abstract :
Huperzine A, 9-amino-13-ethylidene-11-methyl-4-azatricyclo [7.3.1.0(3,8)]trideca-3(8),6,11-trien-5-one, C15H18N2O, Mr = 242.32, monoclinic, P2(1)/n, a = 8.8574 (6), b = 12.1833 (7), c = 12.4278 (7) A, beta = 99.956 (5) degrees, V = 1320.9 (1) A3, Z = 4, Dx = 1.22 g cm-3, lambda(Cu K alpha) = 1.54178 A, mu = 5.75 cm-1, F(000) = 520, T = 296 K, RF = 6.30% for 1402 reflections with Fo greater than or equal to 5 sigma(Fo) and 183 parameters. The pyridone ring is planar and the stereochemistry of the C(11)--C(12) double bond is E. |
| PubMedSearch : Geib_1991_Acta.Crystallogr_C824 |
| PubMedID: 1863425 |
| Inhibitor | HuperzineA |
Geib SJ, Tuckmantel W, Kozikowski AP (1991)
Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease
Acta Crystallographica
C47 pt4 :824
Geib SJ, Tuckmantel W, Kozikowski AP (1991)
Acta Crystallographica
C47 pt4 :824