Full name : Kozikowski Alan P
First name : Alan P
Mail : 89 Headquarters Plaza. North Tower, 14th Floor, Morristown NJ 07960
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Country : USA
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Phone : 201-984-1777
Fax : 201-993-1685
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Comment
| Title : Synthesis and biological evaluation of novel hybrids of highly potent and selective alpha4beta2-Nicotinic acetylcholine receptor (nAChR) partial agonists - Zhang_2016_Eur.J.Med.Chem_124_689 |
| Author(s) : Zhang HK , Eaton JB , Fedolak A , Gunosewoyo H , Onajole OK , Brunner D , Lukas RJ , Yu LF , Kozikowski AP |
| Ref : Eur Journal of Medicinal Chemistry , 124 :689 , 2016 |
| Abstract : |
| PubMedSearch : Zhang_2016_Eur.J.Med.Chem_124_689 |
| PubMedID: 27639361 |
| Title : Structural analogs of huperzine A improve survival in guinea pigs exposed to soman - Gunosewoyo_2013_Bioorg.Med.Chem.Lett_23_1544 |
| Author(s) : Gunosewoyo H , Tipparaju SK , Pieroni M , Wang Y , Doctor BP , Nambiar MP , Kozikowski AP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :1544 , 2013 |
| Abstract : |
| PubMedSearch : Gunosewoyo_2013_Bioorg.Med.Chem.Lett_23_1544 |
| PubMedID: 23395652 |
| Title : Chemistry and behavioral studies identify chiral cyclopropanes as selective alpha4beta2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile - Zhang_2012_J.Med.Chem_55_717 |
| Author(s) : Zhang H , Tuckmantel W , Eaton JB , Yuen PW , Yu LF , Bajjuri KM , Fedolak A , Wang D , Ghavami A , Caldarone B , Paterson NE , Lowe DA , Brunner D , Lukas RJ , Kozikowski AP |
| Ref : Journal of Medicinal Chemistry , 55 :717 , 2012 |
| Abstract : |
| PubMedSearch : Zhang_2012_J.Med.Chem_55_717 |
| PubMedID: 22171543 |
| Title : Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380 - Caldarone_2011_Psychopharmacology.(Berl)_217_199 |
| Author(s) : Caldarone BJ , Wang D , Paterson NE , Manzano M , Fedolak A , Cavino K , Kwan M , Hanania T , Chellappan SK , Kozikowski AP , Olivier B , Picciotto MR , Ghavami A |
| Ref : Psychopharmacology (Berl) , 217 :199 , 2011 |
| Abstract : |
| PubMedSearch : Caldarone_2011_Psychopharmacology.(Berl)_217_199 |
| PubMedID: 21487659 |
| Title : Discovery of isoxazole analogues of sazetidine-A as selective alpha4beta2-nicotinic acetylcholine receptor partial agonists for the treatment of depression - Liu_2011_J.Med.Chem_54_7280 |
| Author(s) : Liu J , Yu LF , Eaton JB , Caldarone B , Cavino K , Ruiz C , Terry M , Fedolak A , Wang D , Ghavami A , Lowe DA , Brunner D , Lukas RJ , Kozikowski AP |
| Ref : Journal of Medicinal Chemistry , 54 :7280 , 2011 |
| Abstract : |
| PubMedSearch : Liu_2011_J.Med.Chem_54_7280 |
| PubMedID: 21905669 |
| Title : The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques - Malkova_2011_Neuropharmacol_60_1262 |
| Author(s) : Malkova L , Kozikowski AP , Gale K |
| Ref : Neuropharmacology , 60 :1262 , 2011 |
| Abstract : |
| PubMedSearch : Malkova_2011_Neuropharmacol_60_1262 |
| PubMedID: 21185313 |
| Title : Poster: The nAChR agonist AMOP-H-OH (sazetidine-A) exhibits reinforcing, but not withdrawal-alleviating, properties in rats - |
| Author(s) : Hackett A , Caldarone B , Kozikowski AP , Ghavami A , Olivier B , Hanania T , Paterson NE |
| Ref : Biochemical Pharmacology , 78 :919 , 2009 |
| PubMedID: |
| Title : 18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons - Valette_2009_J.Nucl.Med_50_1349 |
| Author(s) : Valette H , Xiao Y , Peyronneau MA , Damont A , Kozikowski AP , Wei ZL , Kassiou M , Kellar KJ , Dolle F , Bottlaender M |
| Ref : J Nucl Med , 50 :1349 , 2009 |
| Abstract : |
| PubMedSearch : Valette_2009_J.Nucl.Med_50_1349 |
| PubMedID: 19652217 |
| Title : The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice - Pibiri_2008_Proc.Natl.Acad.Sci.U.S.A_105_14169 |
| Author(s) : Pibiri F , Kozikowski AP , Pinna G , Auta J , Kadriu B , Costa E , Guidotti A |
| Ref : Proc Natl Acad Sci U S A , 105 :14169 , 2008 |
| Abstract : |
| PubMedSearch : Pibiri_2008_Proc.Natl.Acad.Sci.U.S.A_105_14169 |
| PubMedID: 18784370 |
| Title : Acetylenic pyridines for use in PET imaging of nicotinic receptors - |
| Author(s) : Kozikowski AP , Chellappan SK , Henderson D , Fulton R , Giboureau N , Xiao Y , Wei ZL , Guilloteau D , Emond P , Dolle F , Kellar KJ , Kassiou M |
| Ref : ChemMedChem , 2 :54 , 2007 |
| PubMedID: 17096450 |
| Title : Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors - |
| Author(s) : Kozikowski AP , Chellappan SK , Xiao Y , Bajjuri KM , Yuan H , Kellar KJ , Petukhov PA |
| Ref : ChemMedChem , 2 :1157 , 2007 |
| PubMedID: 17530728 |
| Title : Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity - Chellappan_2006_J.Med.Chem_49_2673 |
| Author(s) : Chellappan SK , Xiao Y , Tueckmantel W , Kellar KJ , Kozikowski AP |
| Ref : Journal of Medicinal Chemistry , 49 :2673 , 2006 |
| Abstract : |
| PubMedSearch : Chellappan_2006_J.Med.Chem_49_2673 |
| PubMedID: 16640326 |
| Title : Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them - Xiao_2006_Mol.Pharmacol_70_1454 |
| Author(s) : Xiao Y , Fan H , Musachio JL , Wei ZL , Chellappan SK , Kozikowski AP , Kellar KJ |
| Ref : Molecular Pharmacology , 70 :1454 , 2006 |
| Abstract : |
| PubMedSearch : Xiao_2006_Mol.Pharmacol_70_1454 |
| PubMedID: 16857741 |
| Title : Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits - Wei_2005_J.Med.Chem_48_1721 |
| Author(s) : Wei ZL , Xiao Y , Yuan H , Baydyuk M , Petukhov PA , Musachio JL , Kellar KJ , Kozikowski AP |
| Ref : Journal of Medicinal Chemistry , 48 :1721 , 2005 |
| Abstract : |
| PubMedSearch : Wei_2005_J.Med.Chem_48_1721 |
| PubMedID: 15771418 |
| Title : Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors - Wei_2004_Bioorg.Med.Chem.Lett_14_1855 |
| Author(s) : Wei ZL , Xiao Y , Kellar KJ , Kozikowski AP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1855 , 2004 |
| Abstract : |
| PubMedSearch : Wei_2004_Bioorg.Med.Chem.Lett_14_1855 |
| PubMedID: 15050615 |
| Title : Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues - Wei_2003_J.Med.Chem_46_921 |
| Author(s) : Wei ZL , Petukhov PA , Xiao Y , Tuckmantel W , George C , Kellar KJ , Kozikowski AP |
| Ref : Journal of Medicinal Chemistry , 46 :921 , 2003 |
| Abstract : |
| PubMedSearch : Wei_2003_J.Med.Chem_46_921 |
| PubMedID: 12620069 |
| Title : Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues - Wei_2003_Org.Biomol.Chem_1_3878 |
| Author(s) : Wei ZL , Xiao Y , George C , Kellar KJ , Kozikowski AP |
| Ref : Org Biomol Chem , 1 :3878 , 2003 |
| Abstract : |
| PubMedSearch : Wei_2003_Org.Biomol.Chem_1_3878 |
| PubMedID: 14664377 |
| Title : Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B - Rajendran_2002_Bioorg.Med.Chem.Lett_12_1521 |
| Author(s) : Rajendran V , Saxena A , Doctor BP , Kozikowski AP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :1521 , 2002 |
| Abstract : |
| PubMedSearch : Rajendran_2002_Bioorg.Med.Chem.Lett_12_1521 |
| PubMedID: 12031333 |
| Title : Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring - Campiani_1998_Bioorg.Med.Chem.Lett_8_1413 |
| Author(s) : Campiani G , Kozikowski AP , Wang S , Ming L , Nacci V , Saxena A , Doctor BP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :1413 , 1998 |
| Abstract : |
| PubMedSearch : Campiani_1998_Bioorg.Med.Chem.Lett_8_1413 |
| PubMedID: 9871776 |
| Title : Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A - Raves_1997_Nat.Struct.Biol_4_57 |
| Author(s) : Raves ML , Harel M , Pang YP , Silman I , Kozikowski AP , Sussman JL |
| Ref : Nat Struct Biol , 4 :57 , 1997 |
| Abstract : |
| PubMedSearch : Raves_1997_Nat.Struct.Biol_4_57 |
| PubMedID: 8989325 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases - Saxena_1994_Protein.Sci_3_1770 |
| Author(s) : Saxena A , Qian N , Kovach IM , Kozikowski AP , Pang YP , Vellom DC , Radic Z , Quinn DM , Taylor P , Doctor BP |
| Ref : Protein Science , 3 :1770 , 1994 |
| Abstract : |
| PubMedSearch : Saxena_1994_Protein.Sci_3_1770 |
| PubMedID: 7849595 |
| Title : Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo - Tang_1994_J.Ethnopharmacol_44_147 |
| Author(s) : Tang XC , Kindel GH , Kozikowski AP , Hanin I |
| Ref : J Ethnopharmacol , 44 :147 , 1994 |
| Abstract : |
| PubMedSearch : Tang_1994_J.Ethnopharmacol_44_147 |
| PubMedID: 7898122 |
| Title : Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies - Pang_1994_J.Comput.Aided.Mol.Des_8_669 |
| Author(s) : Pang YP , Kozikowski AP |
| Ref : J Comput Aided Mol Des , 8 :669 , 1994 |
| Abstract : |
| PubMedSearch : Pang_1994_J.Comput.Aided.Mol.Des_8_669 |
| PubMedID: 7738603 |
| Title : Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program - Pang_1994_J.Comput.Aided.Mol.Des_8_683 |
| Author(s) : Pang YP , Kozikowski AP |
| Ref : J Comput Aided Mol Des , 8 :683 , 1994 |
| Abstract : |
| PubMedSearch : Pang_1994_J.Comput.Aided.Mol.Des_8_683 |
| PubMedID: 7738604 |
| Title : Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo - Hanin_1993_Ann.N.Y.Acad.Sci_695_304 |
| Author(s) : Hanin I , Tang XC , Kindel GL , Kozikowski AP |
| Ref : Annals of the New York Academy of Sciences , 695 :304 , 1993 |
| Abstract : |
| PubMedSearch : Hanin_1993_Ann.N.Y.Acad.Sci_695_304 |
| PubMedID: 8239300 |
| Title : Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease - Geib_1991_Acta.Crystallogr_C824 |
| Author(s) : Geib SJ , Tuckmantel W , Kozikowski AP |
| Ref : Acta Crystallographica , C47 pt4 :824 , 1991 |
| Abstract : |
| PubMedSearch : Geib_1991_Acta.Crystallogr_C824 |
| PubMedID: 1863425 |
| Title : Neurochemistry of aging. 2. Design, synthesis, and biological evaluation of halomethyl analogues of choline with high affinity choline transport inhibitory activity - Mistry_1991_J.Med.Chem_34_2031 |
| Author(s) : Mistry JS , Abraham DJ , Kozikowski AP , Hanin I |
| Ref : Journal of Medicinal Chemistry , 34 :2031 , 1991 |
| Abstract : |
| PubMedSearch : Mistry_1991_J.Med.Chem_34_2031 |
| PubMedID: 2066974 |