Title : Antinociceptive effect of R-(+)-hyoscyamine on the conjunctival reflex test in rabbits - Ghelardini_1999_Jpn.J.Pharmacol_81_34 |
Author(s) : Ghelardini C , Galeotti N , Fantetti L , Gualtieri F , Scapecchi S , Bartolini A |
Ref : Japanese Journal of Pharmacology , 81 :34 , 1999 |
Abstract :
R-(+)-Hyoscyamine (1-10 microg/kg, s.c.) dose-dependently increased the local anesthetic effect of procaine (50 microg/ml) and lidocaine (50 microg/ml) in the conjunctival reflex test in the rabbit. This potentiating effect is completely prevented by the M1 antagonist dicyclomine (10 mg/kg, s.c.). The intensity of R-(+)-hyoscyamine antinociception was comparable to that induced by morphine (2 mg/kg, s.c.) and minaprine (15 mg/kg, s.c.), used as analgesic reference drugs. In the same experimental conditions, the S-(-)-enantiomer of atropine (0.1-10 microg/kg, s.c.), was completely ineffective. The present results confirm the ability of R-(+)-hyoscyamine to produce a paradoxical antinociceptive effect mediated by a cholinergic mechanism not only in rodents but also in the rabbit. |
PubMedSearch : Ghelardini_1999_Jpn.J.Pharmacol_81_34 |
PubMedID: 10580368 |
Ghelardini C, Galeotti N, Fantetti L, Gualtieri F, Scapecchi S, Bartolini A (1999)
Antinociceptive effect of R-(+)-hyoscyamine on the conjunctival reflex test in rabbits
Japanese Journal of Pharmacology
81 :34
Ghelardini C, Galeotti N, Fantetti L, Gualtieri F, Scapecchi S, Bartolini A (1999)
Japanese Journal of Pharmacology
81 :34