Gomes-Copeland_2022_Plants.(Basel)_11_

Reference

Title : Hippeastrum stapfianum (Kraenzl.) R.S.Oliveira & Dutilh (Amaryllidaceae) Ethanol Extract Activity on Acetylcholinesterase and PPAR-alpha\/gamma Receptors - Gomes-Copeland_2022_Plants.(Basel)_11_
Author(s) : Gomes-Copeland KKP , Meireles CG , Gomes JVD , Torres AG , Sinoti SBP , Fonseca-Bazzo YM , Magalhaes PO , Fagg CW , Simeoni LA , Silveira D
Ref : Plants (Basel) , 11 : , 2022
Abstract :

Hippeastrum stapfianum (Kraenzl.) R.S.Oliveira & Dutilh (Amaryllidaceae) is an endemic plant species from the Brazilian savannah with biological and pharmacological potential. This study evaluated the effects of ethanol extract from H. stapfianum leaves on acetylcholinesterase enzyme activity and the action on nuclear receptors PPAR-alpha and PPAR-gamma. A gene reporter assay was performed to assess the PPAR agonist or antagonist activity with a non-toxic dose of H. stapfianum ethanol extract. The antioxidant capacity was investigated using DPPH() scavenging and fosfomolybdenium reduction assays. The identification of H. stapfianum's chemical composition was performed by gas chromatography-mass spectrometry (GC-MS) and HPLC. The ethanol extract of H. stapfianum activated PPAR-alpha and PPAR-gamma selectively, inhibited the acetylcholinesterase enzyme, and presented antioxidant activity in an in vitro assay. The major compounds identified were lycorine, 7-demethoxy-9-O-methylhostasine, and rutin. Therefore, H. stapfianum is a potential source of drugs for Alzheimer's disease due to its ability to activate PPAR receptors, acetylcholinesterase inhibition activity, and antioxidant attributes.

PubMedSearch : Gomes-Copeland_2022_Plants.(Basel)_11_
PubMedID: 36432907

Related information

Citations formats

Gomes-Copeland KKP, Meireles CG, Gomes JVD, Torres AG, Sinoti SBP, Fonseca-Bazzo YM, Magalhaes PO, Fagg CW, Simeoni LA, Silveira D (2022)
Hippeastrum stapfianum (Kraenzl.) R.S.Oliveira & Dutilh (Amaryllidaceae) Ethanol Extract Activity on Acetylcholinesterase and PPAR-alpha\/gamma Receptors
Plants (Basel) 11 :

Gomes-Copeland KKP, Meireles CG, Gomes JVD, Torres AG, Sinoti SBP, Fonseca-Bazzo YM, Magalhaes PO, Fagg CW, Simeoni LA, Silveira D (2022)
Plants (Basel) 11 :