Gorshkova_2001_Bull.Exp.Biol.Med_131_446

Reference

Title : Effect of tetraalkylammonium derivative of 6-methyluracil on amplitude and temporal parameters of miniature endplate potentials in frog neuromuscular junction - Gorshkova_2001_Bull.Exp.Biol.Med_131_446
Author(s) : Gorshkova OV , Zobov VV , Bukharaeva EA , Nikolsky EE , Akamsin VD , Galyametdinova IV , Reznik VS
Ref : Bulletin of Experimental Biology & Medicine , 131 :446 , 2001
Abstract : The effect of C-547, a tetraalkylammonium derivative of 6-methyluracil, a novel highly selective acetylcholinesterase inhibitor, on frog neuromuscular junction was studied. In concentrations 10(-9)-10(-7)M the preparation increased the amplitude and temporal parameters of miniature endplate potentials. In contrast to the effect of C-574 on purified acetylcholinesterase from mammals, the effect of this agent on frog neuromuscular junction was reversible. In a concentration of 10(-6)M the preparation apart from anticholinesterase activity produced a parasympatholytic effect manifested in a decrease in amplitude and decay time constant of miniature endplate potentials accompanied by a decrease in spontaneous transmitter secretion. After washout, the parasympatholytic effect recovered more slowly, but disappeared more rapidly compared to anticholinesterase activity. These findings suggest that parasympatholytic effect of C-547 results from direct action on receptor-channel complexes in the endplate membrane.
ESTHER : Gorshkova_2001_Bull.Exp.Biol.Med_131_446
PubMedSearch : Gorshkova_2001_Bull.Exp.Biol.Med_131_446
PubMedID: 11550049

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Citations formats

Gorshkova OV, Zobov VV, Bukharaeva EA, Nikolsky EE, Akamsin VD, Galyametdinova IV, Reznik VS (2001)
Effect of tetraalkylammonium derivative of 6-methyluracil on amplitude and temporal parameters of miniature endplate potentials in frog neuromuscular junction
Bulletin of Experimental Biology & Medicine 131 :446

Gorshkova OV, Zobov VV, Bukharaeva EA, Nikolsky EE, Akamsin VD, Galyametdinova IV, Reznik VS (2001)
Bulletin of Experimental Biology & Medicine 131 :446