| Title : The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex) derivaties - Gregor_1992_Bioorg.Med.Chem.Letters_2_861 |
| Author(s) : Gregor VE , Emmerling MR , Lee C , Moore CJ |
| Ref : Bioorganic & Medicinal Chemistry Letters , 2 :861 , 1992 |
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Abstract :
Chlorosubstituted derivatives of tacrine (1), 1,4-methylenetacrine (2), and their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities are described. The most potent analogues are 6-chlorotacrine (1b) in AChE and 7-chlorotacrine (1c) in BChE inhibition. |
| PubMedSearch : Gregor_1992_Bioorg.Med.Chem.Letters_2_861 |
| PubMedID: |
| Inhibitor | 6-chlorotacrine |
Gregor VE, Emmerling MR, Lee C, Moore CJ (1992)
The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex) derivaties
Bioorganic & Medicinal Chemistry Letters
2 :861
Gregor VE, Emmerling MR, Lee C, Moore CJ (1992)
Bioorganic & Medicinal Chemistry Letters
2 :861