6-chlorotacrine
General
Type : Derivative of Tacrine
Chemical_Nomenclature : 6-chloro-1,2,3,4-tetrahydroacridin-9-amine
Canonical SMILES : C1CCC2=NC3=C(C=CC(=C3)Cl)C(=C2C1)N
InChI : InChI=1S\/C13H13ClN2\/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15\/h5-7H,1-4H2,(H2,15,16)
InChIKey : GQZMDBQRGRRPMS-UHFFFAOYSA-N
Other name(s) : Tacrine Analogue 4, 6-chlorotacrine.HCl, 6-Chlorotacrine HCl, 6-chloro-1,2,3,4-tetrahydroacridin-9-amine, 6-chlorotacrine hydrochloride
MW : 232.71
Formula : C13H13ClN2
CAS_number :
PubChem : 10399068
UniChem : GQZMDBQRGRRPMS-UHFFFAOYSA-N
Target
Families : 6-chlorotacrine ligand of proteins in family
ACHE
References (5)
| Title : Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease - Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| Author(s) : Kaniakova M , Nepovimova E , Kleteckova L , Skrenkova K , Holubova K , Chrienova Z , Hepnarova V , Kucera T , Kobrlova T , Vales K , Korabecny J , Soukup O , Horak M |
| Ref : Curr Alzheimer Res , 16 :821 , 2019 |
| PubMedID: 30819076 |
| Title : Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects - Misik_2018_Curr.Alzheimer.Res_15_552 |
| Author(s) : Misik J , Nepovimova E , Pejchal J , Kassa J , Korabecny J , Soukup O |
| Ref : Curr Alzheimer Res , 15 :552 , 2018 |
| PubMedID: 29231138 |
| Title : Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice - Kassa_2017_Acta.Medica.(Hradec.Kralove)_60_140 |
| Author(s) : Kassa J , Korabecny J |
| Ref : Acta Medica (Hradec Kralove) , 60 :140 , 2017 |
| PubMedID: 29716679 |
| Title : Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds - Camps_2009_J.Med.Chem_52_5365 |
| Author(s) : Camps P , Formosa X , Galdeano C , Munoz-Torrero D , Ramirez L , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Huertas O , Dafni T , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 52 :5365 , 2009 |
| PubMedID: 19663388 |
| Title : Binding of tacrine and 6-chlorotacrine by acetylcholinesterase - Wlodek_1996_Biopolymers_38_109 |
| Author(s) : Wlodek ST , Antosiewicz J , McCammon JA , Straatsma TP , Gilson MK , Briggs JM , Humblet C , Sussman JL |
| Ref : Biopolymers , 38 :109 , 1996 |
| PubMedID: 8679940 |