Guo_2022_Nat.Metab_4_1352

Reference

Title : Cdo1 promotes PPARgamma-mediated adipose tissue lipolysis in male mice - Guo_2022_Nat.Metab_4_1352
Author(s) : Guo YY , Li BY , Xiao G , Liu Y , Guo L , Tang QQ
Ref : Nat Metab , 4 :1352 , 2022
Abstract :

Cysteine dioxygenase 1 (Cdo1) is a key enzyme in taurine synthesis. Here we show that Cdo1 promotes lipolysis in adipose tissue. Adipose-specific knockout of Cdo1 in mice impairs energy expenditure, cold tolerance and lipolysis, exacerbates diet-induced obesity (DIO) and decreases adipose expression of the key lipolytic genes encoding ATGL and HSL, with little effect on adipose taurine levels. White-adipose-specific overexpression of ATGL and HSL blunts the role of adipose Cdo1 deficiency in promoting DIO. Mechanistically, Cdo1 interacts with PPARgamma and facilitates the recruitment of Med24, the core subunit of mediator complex, to ATGL and HSL gene promoters, thereby transactivating their expression. Further, mice with transgenic overexpression of Cdo1 show better cold tolerance, ameliorated DIO and higher lipolysis capacity. Thus, we uncover an unexpected and important role of Cdo1 in regulating adipose lipolysis.

PubMedSearch : Guo_2022_Nat.Metab_4_1352
PubMedID: 36253617

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Citations formats

Guo YY, Li BY, Xiao G, Liu Y, Guo L, Tang QQ (2022)
Cdo1 promotes PPARgamma-mediated adipose tissue lipolysis in male mice
Nat Metab 4 :1352

Guo YY, Li BY, Xiao G, Liu Y, Guo L, Tang QQ (2022)
Nat Metab 4 :1352