| Title : 4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase - Han_2016_Bioorg.Med.Chem.Lett_26_1184 |
| Author(s) : Han Q , Pabba PK , Barbosa J , Mabon R , Healy JP , Gardyan MW , Terranova KM , Brommage R , Thompson AY , Schmidt JM , Wilson AG , Xu X , Tarver JE, Jr. , Carson KG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :1184 , 2016 |
|
Abstract :
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified. |
| PubMedSearch : Han_2016_Bioorg.Med.Chem.Lett_26_1184 |
| PubMedID: 26821819 |
Han Q, Pabba PK, Barbosa J, Mabon R, Healy JP, Gardyan MW, Terranova KM, Brommage R, Thompson AY, Schmidt JM, Wilson AG, Xu X, Tarver JE, Jr., Carson KG (2016)
4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase
Bioorganic & Medicinal Chemistry Lett
26 :1184
Han Q, Pabba PK, Barbosa J, Mabon R, Healy JP, Gardyan MW, Terranova KM, Brommage R, Thompson AY, Schmidt JM, Wilson AG, Xu X, Tarver JE, Jr., Carson KG (2016)
Bioorganic & Medicinal Chemistry Lett
26 :1184