Carson KG

References (2)

Title : Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase - Tarver_2016_Bioorg.Med.Chem.Lett_26_1525
Author(s) : Tarver JE, Jr. , Pabba PK , Barbosa J , Han Q , Gardyan MW , Brommage R , Thompson AY , Schmidt JM , Wilson AG , He W , Lombardo VK , Carson KG , Wilson AGE
Ref : Bioorganic & Medicinal Chemistry Lett , 26 :1525 , 2016
Abstract : A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified.
ESTHER : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525
PubMedSearch : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525
PubMedID: 26897593
Gene_locus related to this paper: human-NOTUM

Title : 4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase - Han_2016_Bioorg.Med.Chem.Lett_26_1184
Author(s) : Han Q , Pabba PK , Barbosa J , Mabon R , Healy JP , Gardyan MW , Terranova KM , Brommage R , Thompson AY , Schmidt JM , Wilson AG , Xu X , Tarver JE, Jr. , Carson KG
Ref : Bioorganic & Medicinal Chemistry Lett , 26 :1184 , 2016
Abstract : A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified.
ESTHER : Han_2016_Bioorg.Med.Chem.Lett_26_1184
PubMedSearch : Han_2016_Bioorg.Med.Chem.Lett_26_1184
PubMedID: 26821819